2,185 research outputs found
More than one million barriers fragment Europe’s rivers
No full textEC Horizon 2020 Research and Innovation Programme, AMBER (Adaptive Management of Barriers in European Rivers) Project, grant agreement number 689682 (...)Belletti, B., Garcia de Leaniz, C., Jones, J., Bizzi, S., Börger, L., Segura, G., Castelletti, A., van de Bund, W., Aarestrup, K., Barry, J., Belka, K., Berkhuysen, A., Birnie-Gauvin, K., Bussettini, M., Carolli, M., Consuegra, S., Dopico, E., Feierfeil, T., Fernández, S., Fernandez Garrido, P., Garcia-Vazquez, E., Garrido, S., Giannico, G., Gough, P., Jepsen, N., Jones, P.E., Kemp, P., Kerr, J., King, J., Łapińska, M., Lázaro, G., Lucas, M.C., Marcello, L., Martin, P., McGinnity, P., O’Hanley, J., Olivo del Amo, R., Parasiewicz, P., Pusch, M., Rincon, G., Rodriguez, C., Royte, J., Schneider, C.T., Tummers, J.S., Vallesi, S., Vowles, A., Verspoor, E., Wanningen, H., Wantzen, K.M., Wildman, L., Zalewski, M
COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation
No full textSummaryMitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional significance of COX7A2L in the structural organization of the mammalian respiratory chain. As in the mouse, human COX7A2L binds primarily to free mitochondrial complex III and, to a minor extent, to complex IV to specifically promote the stabilization of the III2+IV supercomplex without affecting respirasome formation. Furthermore, COX7A2L does not affect the biogenesis, stabilization, and function of the individual oxidative phosphorylation complexes. These data show that independent regulatory mechanisms for the biogenesis and turnover of different MRC supercomplex structures co-exist
Investigation in the CB1 and CB2 receptor binding profile and intrinsic activity of (−) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives
No full textCannabidiol (CBD) and cannabidivarin (CBDV) have shown promising clinical efficacy for the management of epilepsy, and beneficial effects have been demonstrated for CBD in a diversity of other pathologies (pain, schizophrenia, Tourette syndrome, anxiety). However, the mechanism(s) involved are still largely elusive, as are the molecular target(s) involved. CBD and CBDV do not orthosterically bind the cannabinoid type-1 (CB1) and type-2 (CB2) receptors, showing only modest allosteric modulation of both end-points. CBD and CBDV are biosynthesized as optically highly pure (−)-enantiomers, and most bioactivity data refer to these forms. (+)-CBD and related analogues [(+)-cannabidiolic acid (CBDA), its esters, and (+)-CBDV] can be obtained by chemical synthesis, and we present evidence that the (+)- and (−)-enantiomers of CBD, CBDV and of a selection of derivatives of CBDA have distinct binding profiles and functional activity at the CB1/CB2 receptors. Thus, with the single exception of the methyl ester of CBDA, all the (+)-enantiomers showed higher affinities than the (−)-isomers for both receptors, in particular for the CB2 receptors. The affinity of the (+)-enantiomers for both CB1 and CB2 receptors showed a marked dependence on the nature of the alkyl residue on the aromatic ring and the esterification pattern of CBDA. Potency was rarely in the low nM value for CB1, but generally so for CB2. Enantiomers showing low nM activity were further investigated for their intrinsic activity using GTPγS binding assays. This proved that (+)-CBD, (+)-CBDV and the methyl ester of (+)-CBDA are agonists at the CB2 receptor, with the β-hydroxyethyl ester of (+)-CBDA being an inverse agonist, and its β-hydroxypentyl ester behaving as an agonist at CB1 and an inverse agonist at CB2. Finally, we assayed in vitro the anti-inflammatory and neuroprotective properties of three compounds [(+)-CBD, (+)-CBDV and (+)-CBDA methyl ester] strongly activating CB2, showing their ability to reduce the production of proinflammatory factors and protecting neurons against their toxicity. Remarkably, these benefits were eliminated by the selective blockade of the CB2 receptor, highlighting its role as a (+)-CBD target. In summary, our data show that remarkable differences between (−)- and (+)-enantiomers of CBD, CBDV and related compounds exist in terms of CB1/CB2 receptor binding profile and intrinsic activity. The observation that the natural (−)-enantiomers do not bind CB2 receptors suggests that their effects are associated with different targets
Search for light bosons in the final state with muons and tau leptons with CMS Run II data
No full textA search for a pair of light bosons produced in decays of the 125 GeV Higgs boson, with one of the light states decaying into a pair of muons and the other into a pair of tau leptons, is presented. The search is based on a data sample corresponding to an integrated luminosity of 137.2 fb−1, collected with the CMS detector at the CERN Large Hadron Collider in the years 2016, 2017, and 2018 at a center-of-mass energy of 13 TeV. An extended Higgs sector is well motivated in a vast set of Beyond the Standard Model theories such as the two Higgs doublets plus one additional singlet (2HDM+S) and the Dark Photon Model. In the context of these models, the 125 GeV Higgs boson can decay into a pair of light bosons, which subsequently decay to pairs of Standard Model particles. Considering the enhanced coupling of the light bosons to leptons for some of the scenarios within these models, the final state considered in this work results of particular interest. Masses of the light boson between 3.6 and 21 GeV are probed, which leads to an experimental signature in the detector with both the muon pair and visible decay products from the tau pair being highly collimated. The analysis benefits from the efficient identification and reconstruction of muons by the CMS detector. Using Multivariate Analysis Techniques, the information on several kinematic variables is exploited to enhance the sensitivity to the targeted topology. No significant excess of events is found above the Standard Model expectation. Therefore, model-independent upper limits at 95% confidence level on the 125 GeV Higgs boson production cross-section times the branching fraction into the studied final state are set. Model-specific upper bounds are obtained as constraints on the parameter space of the different benchmark scenarios within the 2HDM+S and the Dark Photon Model
Team Role Dynamics in Collaborative Research Teams: A Key to Participatory School Development
No full textIn recent decades, schools have faced increasing pressure to meet external expectations for quality and outcomes, requiring school teams, especially when dealing with a (super)diverse student populations, to provide efficient and context-specific responses. Collaborative research emerges as an attractive approach, wherein teams systematically reflect on their educational practices and (should) take data-and evidence-informed action to enhance students' learning. Involving additional stakeholders, such as students and in-service teachers, is considered beneficial, also in preparing pre-service teachers for inclusive education albeit under certain conditions. The current study, therefore, seeks to investigate the complex dynamics and expectations among diverse actors within collaborative research teams engaged in school development processes. This single case study unfolded at the Brussels CityScope Lyceum, where a collaborative research intervention was launched during the 2022-2023 school year to strengthen the student-teacher relationships through the implementation of bimonthly student talks. This school development process involved a diverse team, including teachers, students, pre-service teachers, a school leader and a teacher educator. Individual concept map-mediated interviews, based on Mumford et al.'s (2008) theoretical framework on team roles for school development, were conducted with 13 members of the collaborative research team. These interviews explored participants' perceptions of role allocation and conceptualization within the team, as well as their views on how these roles contributed to breakthroughs in the school development process. The resulting dataset was subjected to a combined deductive and inductive analysis strategy. The results unveil a landscape of both overlapping and diverging perspectives regarding role allocation and conceptualization among the actors of the collaborative research team. Moreover, the analysis delineates four distinct categories of breakthroughs that propelled the school development process forward in this particular case, with the following roles proving crucial: (1) cooperators and communicators foster connected communication and interaction, (2) contributors and critics enhance the enriching diversity of perspectives, (3) the consul role contributes to supportive leadership, and (4) creators and contractors guide processes of co-creation. The findings suggest that although all team roles are fulfilled, actors' expectations towards each other are only partially met, indicating potential for growth in creating truly participatory, reciprocal spaces for collaborative research. Despite these divergences, roles critical to the transformative potential of the school development process are assumed by multiple actors, possibly contributing to the success of the collaborative research in this case. Points of Interest • Collaborative research serves as an approach for school development at CityScope Lyceum in Brussels, focusing on improving student-teacher relationships by setting up periodic student talks. • Apart from teachers, pre-service teachers and a teacher educator, students are active participants in this collaborative research. • Within the collaborative research team, various actors assume distinct roles that complement each other, including those roles that prove crucial to the transformative potential of the school development process. • Yet, there is notable divergence among the actors in their allocation and conceptualization of team roles, suggesting the need to improve alignment in this regard, as well as transparent and intentional role assignment in settings of collaborative research for school development.The author(s) received no financial support for the research, authorship, and/or publication of this articl
Search for a very light NMSSM Higgs Boson produced in decays of the 125 GeV scalar boson, decaying into a pair of muons and a pair of leptons at = 13TeV
No full textMeasurement of the CP-violating phase phi(s) in the B-s(0) -> J/psi phi(1020) -> mu(+)mu-K+K- channel in proton-proton collisions at root s=13 TeV
No full textThe CP-violating weak phase ?s and the decay width difference ??s between the light and heavy B0s mass eigenstates are measured with the CMS detector at the LHC in a sample of 48 500 reconstructed B0s? J/I) d (1020) ?11+11? K+K? events. The measurement is based on a data sample corresponding to an integrated luminosity of 96.4 fb?1, collected in proton-proton collisions at ?s = 13 TeV in 2017?2018. To extract the values of ?s and ??s, a time-dependent and flavor-tagged angular analysis of the 11+11?K+K? final state is performed. The analysis employs a dedicated tagging trigger and a novel opposite-side muon flavor tagger based on machine learning techniques. The measurement yields ?s = ?11 ?50 (stat) ? 10 (syst) mrad and ??s = 0.114 ? 0.014 (stat)? 0.007 (syst) ps?1, in agreement with the standard model predictions. When combined with the previous CMS measurement at ?s = 8 TeV, the following values are obtained: ?s = ?21 ? 44 (stat) ? 10 (syst) mrad, ??s = 0.1032 ? 0.0095 (stat) ? 0.0048 (syst) ps?1, a significant improvement over the 8 TeV result. ? 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY licens
Transformando e innovando la experiencia para refrescar tus bebidas con ICE GLASS
No full textIntroducción: El proyecto ICE GLASS es una iniciativa empresarial enfocada en la innovación y sostenibilidad dentro de la industria de envases. Su propósito principal es desarrollar y distribuir vasos fabricados con materiales reciclados, ofreciendo una solución ecológica para el consumo de bebidas frías. Objetivo: reducir la acumulación de residuos mediante el uso de materiales reciclados, promoviendo una economía circular que minimice el impacto ambiental. Método: ICE GLASS ha diseñado una metodología integral que combina sostenibilidad, innovación y gestión empresarial. En primer lugar, se ha desarrollado un proceso de producción basado en el uso de materiales reciclados y la incorporación de tecnologías limpias. En segundo lugar, se han establecido indicadores clave de impacto para medir la reducción de la huella de carbono, la eficiencia energética y la integración de procesos sostenibles. Por último, se ha diseñado una estrategia de liderazgo que fomente una cultura organizacional comprometida con la sostenibilidad y la responsabilidad social. Resultados: se ha logrado definir un modelo de negocio sostenible que integra eficiencia productiva con un impacto ambiental positivo. Se han desarrollado métricas específicas para evaluar el progreso en la reducción de residuos y el consumo energético, asegurando un monitoreo constante del desempeño ambiental del proyecto. Conclusiones: ICE GLASS representa una solución innovadora para la industria de envases, ofreciendo una alternativa sostenible que responde a las tendencias globales de consumo responsable.Introduction: This project is an entrepreneurial initiative focused on innovation and sustainability within the industry. Its primary goal is to develop and distribute cups made from recycled materials, providing an environmentally friendly solution for the consumption of cold beverages. Objective: To reduce waste accumulation through the use of recycled materials, promoting a circular economy that minimizes environmental impact. Methodology: The project employs a comprehensive approach that integrates sustainability, innovation, and business management. First, a production process has been developed based on the use of recycled materials and the incorporation of clean technologies. Second, key impact indicators have been established to measure carbon footprint reduction, energy efficiency, and the integration of sustainable processes. Finally, a leadership strategy has been designed to foster an organizational culture committed to sustainability and social responsibility. Results: A sustainable business model has been defined, integrating productive efficiency with a positive environmental impact. Methodologies have been developed to assess progress in reducing energy consumption, ensuring continuous environmental monitoring. Conclusions: The project represents an innovative solution, offering a sustainable alternative that aligns with global trends in responsible consumption.Lista de tablas y figuras 5 -- Introducción 6 -- Definición del problema 8 -- Objetivos 10 – Antecedentes 10 -- Método 14 – Resultados 17 -- Propuesta de valor 19 – Branding 23 -- Plan de marketing 27 -- Procesos de negocios 33 -- Rediseño de procesos 43 -- Validación y evaluación del impacto 47 -- Organigrama y cultura 49 -- Proyecciones financieras 55 --- Riesgos 57 -- Aspectos legales 62 -- Pitch de inversión 66 -- Conclusiones 68 --Referencias 71 --Magíster en Administración Modalidad VirtualMaestrí
How do offline and online environments matter in the relational marketing approach?
No full textThe goal of this study is to analyse the relational benefits that the clients of banks, insurance companies, and travel agencies receive according to whether they maintain an offline or online relationship with the company. The development of an index, called the Relational Benefits Index, allows for a comparison of differences that arise between the measures of confidence benefits, social benefits, and special treatment benefits. The results demonstrate significant differences according to the type of service business and channel used, affecting the importance that consumers place on the offline channel when they want to maintain a stable relationship with a service business. © 2017 The Author(s).Universidad Autónoma de Chil
Relationship of Physicochemical Factors with the Biological Quality of Packaged Treated Drinking Water in Production Companies of Cúcuta 2022-2023
No full textDigitalEl agua potable tratada envasada conlleva diversos impactos en la salud, medio ambiente y sociedad. Los riesgos para la salud están relacionados no sólo con la calidad del agua, sino también a la calidad de los contenedores y a las condiciones de almacenamiento. El objetivo de esta investigación fue relacionar los factores fisicoquímicos con la calidad biológica del agua potable tratada envasada en empresas productoras de Cúcuta. Se realizó un estudio correlacional de campo donde se analizaron dos marcas de agua producidas en la ciudad de Cúcuta, se le investigaron las características fisicoquímicas como el pH, temperatura y cloro; y el análisis microbiológico mediante de técnica de filtración por membrana, durante un periodo de 3 meses.
Se evidenció en las características fisicoquímicas la ausencia de cloro en las aguas analizadas. Por otra parte, en el análisis microbiológico se evidencio la presencia de aerobios mesófilos, coliformes totales y coliformes fecales en la primera medición, por lo cual no se cumplieron con los valores estándar definidos en la resolución 2115 del 2007, pero cabe destacar que las muestras en la última medición no se evidenciaron presencia de estos microorganismos, ni tampoco de Pseudomona spp.
A pesar de que la distribución del agua potable tratada envasada está creciendo progresivamente a nivel mundial, se observa que existen empresas que no cumplen con la calidad del producto final en un 100% por tal motivo es necesario realizarles seguimiento al cumplimento de los estándares de calidad de este producto tan vital pata la vida.Packaged treated drinking water has various impacts on health, the environment and society. Health risks are related not only to water quality, but also to the quality of containers and storage conditions. The objective of this research was to relate physicochemical factors with the biological quality of treated drinking water packaged in producing companies in Cúcuta.
A field correlational study was carried out where two brands of water produced in the city of Cúcuta were analyzed, the physicochemical characteristics such as pH, temperature and chlorine were investigated; and microbiological analysis using a membrane filtration technique, over a period of 3 months.
The absence of chlorine in the analyzed waters was evident in the physicochemical characteristics. On the other hand, the microbiological analysis showed the presence of mesophilic aerobes, total coliforms and fecal coliforms in the first measurement, which is why the standard values defined in resolution 2115 of 2007 were not met, but it should be noted that the samples In the last measurement, there was no evidence of the presence of these microorganisms, nor of Pseudomona spp.
Although the distribution of packaged treated drinking water is growing progressively worldwide, it is observed that there are companies that do not comply with the quality of the final product 100%, for this reason it is necessary to monitor compliance with quality standards. of this product so vital for life.Resumen ........................................................................................................................................ 16
Summary ....................................................................................................................................... 18
Introducción .................................................................................................................................. 20
Problema ....................................................................................................................................... 22
Planteamiento del problema .......................................................................................................... 22
Formulación del problema………………………………………………………………………. 24
Objetivos ....................................................................................................................................... 24
Objetivo general ............................................................................................................................ 24
Objetivos específicos .................................................................................................................... 24
Justificación .................................................................................................................................. 25
Pertinencia de la investigación...................................................................................................... 25
Articulación del Proyecto ............................................................................................................. 25
Interés del investigador………………………………………………………………………….. 26
Aportes o Novedad de la Investigación…………………………………………………………. 26
Beneficiarios ................................................................................................................................. 26
Marco Referencial ......................................................................................................................... 27
Antecedentes ................................................................................................................................. 27
Antecedentes internacionales……………………………………………………………………. 27
Antecedentes nacionales ............................................................................................................... 30
Antecedentes regionales................................................................................................................ 33
Marco teórico ................................................................................................................................ 34
Agua Potable Tratada Envasada ................................................................................................... 34
Factores fisicoquímicos del agua .................................................................................................. 36
Color…………………………………………………………………………………………….. 36
Temperatura .................................................................................................................................. 37
Cloro residual libre……………………………………………………………………………… 37
Características Microbiológicas Del Agua ................................................................................... 38
Aerobios mesófilos ....................................................................................................................... 39
Pseudomonas sp…………………………………………………………………………………. 39
Coliformes………………………………………………………………………………………..40
Coliformes totales……………………………………………………………………………….. 40
Coliformes fecales………………………………………………………………………………. 41
Marco Conceptual ......................................................................................................................... 41
Marco Contextual.......................................................................................................................... 43
Marco Legal .................................................................................................................................. 44
Sistema de hipótesis ...................................................................................................................... 45
Hipótesis de trabajo………………………………………………………………………………45
Hipótesis 1:……………………………………………………………………………………… 45
Hipótesis 0: ................................................................................................................................... 46
Operación de las Variables ........................................................................................................... 47
Marco Metodológico ..................................................................................................................... 49
Tipo de investigación .................................................................................................................... 49
Nivel de investigación……………………………………………………………………………49
Diseño de investigación ................................................................................................................ 49
Métodos......................................................................................................................................... 50
Población y Muestra ..................................................................................................................... 56
Población ...................................................................................................................................... 56
Muestra ......................................................................................................................................... 56
Inclusión:....................................................................................................................................... 57
Exclusión: ..................................................................................................................................... 57
Instrumentos de recolección de datos ........................................................................................... 57
Técnicas de procesamiento y análisis de los datos ....................................................................... 58
Técnicas de procesamiento……………………………………………………………………… 58
Análisis estadístico........................................................................................................................ 60
Análisis e interpretación de los resultados .................................................................................... 61
Análisis de los resultados .............................................................................................................. 61
Determinar las características fisicoquímicas del agua potable tratada envasada mediante técnicas estandarizadas con kits comerciales…………………………………………………………… 61
Establecer la relación entre los factores fisicoquímicos y la calidad biológica del agua potable tratada envasada mediante técnicas estadísticas ........................................................................... 65
Discusión....................................................................................................................................... 67
Conclusiones ................................................................................................................................. 74
Conclusión del objetivo general.................................................................................................... 74
Conclusión de los objetivos específicos……………………………………………………….... 74
Recomendaciones ......................................................................................................................... 78
Referencias Bibliográficas ............................................................................................................ 79
Apéndices ...................................................................................................................................... 85PregradoBacteriólogo(a) y Laboratorista ClínicoBiociencia
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