33 research outputs found
Incidence of vulvovaginal candidiasis in women of the Imbabura province
No full textVaginal candidiasis is a relevant topic nowadays and has also become one of the most prevalent diseases in women. Vulvovaginal candidiasis (VVC) is an infection caused by a fungus of the genus Candida, which usually forms part of our commensal gut microbiota. It becomes a health problem when the fungus colonizes the vaginal mucosa in an immunocompromised, pregnant person or follows antibiotic therapy. The fungi can proliferate, surpassing protective microorganisms and causing colonization in the host. Antimycotics are prescribed antimicrobial drugs that stop the growth of fungi or kill them. However, the fungus can acquire resistance to the treatments and pose a severe health risk for many women. The purpose of this project is to determine the prevalence of VVC in a population of women, identify the Candida species causing them, and evaluate the sensitivity of the fungi to commonly prescribed antifungals. This study was carried out since November 2019 to February 2021 in the Imbabura province. In the present investigation, one hundred and thirty-four samples of vaginal cervical exudates from women with symptoms of VVC were obtained in primary care health centers and were analyzed in the laboratories of Yachay Tech University. We conducted screens for fungal pathogens in order to isolate, identify Candida species, and determine the fungus susceptibility to antifungals clinically most used. Among all samples, 31,34% were culture positive. Out of the 30 positive samples, 96.7% were C. albicans, followed by C. parapsilosis (3.3%) while C. glabrata and C. tropicalis were not found. Moreover, C. albicans were identified in women between the ages of 18 and 29. Most isolates were sensitive to clotrimazole and voriconazole, and few were resistant to fluconazole. Our results suggest the identification of Candida species and their antifungal sensitivity testing should be routinely performed to achieve proper treatment and appropriate clinical results.La candidiasis vaginal es un tema relevante en la actualidad y también se ha convertido en una de las enfermedades más prevalentes en la mujer. La candidiasis vulvovaginal (VVC) es una infección causada por el hongo Candida, el cual usualmente forma parte de la microbiota comensal intestinal. Se convierte en un problema de salud cuando el hongo coloniza la mucosa vaginal en una persona inmunodeprimida, embarazada o después de un tratamiento con antibióticos. Los hongos pueden crecer rápidamente, superando a los microorganismos protectores y provocando la colonización en el hospedador. Los antimicóticos son medicamentos antimicrobianos recetados que detienen el crecimiento de los hongos o los matan. Sin embargo, el hongo puede adquirir resistencia a los tratamientos y suponer un grave riesgo para la salud de muchas mujeres. El propósito de este proyecto es determinar la prevalencia de CVV en una población de mujeres, identificar las especies de Candida y evaluar la sensibilidad de los hongos frente a los antifúngicos comúnmente recetados. Este estudio fue realizado desde noviembre de 2019 hasta febrero de 2021 en la provincia de Imbabura. En la presente investigación, se obtuvieron en centros de salud primaria ciento treinta y cuatro muestras de exudados cervicales vaginales de mujeres con síntomas de CVV, que fueron posteriormente analizados en los laboratorios de la Universidad de Investigación de Tecnología Experimental Yachay. Realizamos cribados de hongos patógenos con el fin de aislar, identificar especies de Candida y determinar la susceptibilidad del hongo a los antifúngicos clínicamente más utilizados. De las 30 muestras positivas, 96.7% fueron C. albicans, seguido de C. parapsilosis (3.3%) mientras que no se encontraron C. glabrata y C. tropicalis. Además, C. albicans fue identificada en mujeres entre los 18 y 29 años. La mayoría de aislados fueron sensibles al clotrimazol y voriconazol, y algunos resistentes al fluconazol. Nuestros resultados sugieren que la identificación de las especies de Candida y las pruebas de sensibilidad antifúngica deben realizarse de forma rutinaria para lograr un tratamiento adecuado y resultados clínicos correctos.Biólog
Historia natural de la endocarditis infecciosa en pacientes heroinomanos
No full textCentro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai
TCT-326 In-Hospital and Long-Term Prognosis of Anemia on Admission in Patients Undergoing Percutaneous Coronary Intervention
No full textMID-TERM OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTIONS FOR ESTABLISHED SURGERY CLASS I INDICATIONS AT A NON-CARDIAC SURGERY CENTER
No full textPROGNOSIS SIGNIFICANCE OF CONTRAST-INDUCED ACUTE KIDNEY INJURY IN PATIENTS WITH PREVIOUSLY NORMAL RENAL FUNCTION (UP TO 2 YEARS FOLLOW UP)
No full textBeta-blocker effect on ST-segment:a prespecified analysis of the EARLY-BAMI randomised trial
No full textObjective The effect of early intravenous (IV) beta-blockers (BBs) administration in patients undergoing primary percutaneous coronary intervention (pPCI) on ST-segment deviation is unknown. We undertook a prespecified secondary analysis of the Early Beta-blocker Administration before primary PCI in patients with ST-elevation Myocardial Infarction (EARLY-BAMI) trial to investigate the effect of early IV BB on ST-segment deviation.Methods The EARLY-BAMI trial randomised patients with ST-elevation myocardial infarction (STEMI) to IV metoprolol (2x5 mg bolus) or matched placebo before pPCI. The prespecified outcome, evaluated by an independent core laboratory blinded to study treatment, was the residual ST-segment deviation 1 hour after pPCI (ie, the percentage of patients with >3 mm cumulative ST deviation at 1 hour after pPCI).Results An ECG for the evaluation of residual ST-segment deviation 1 hour after pPCI was available in 442 out of 683 randomised patients. The BB group had a lower heart rate after pPCI compared with placebo (71.2 +/- 13.2 vs 74.3 +/- 13.6, p=0.016); however, no differences were noted in the percentages of patients with >3 mm cumulative ST deviation at 1 hour after pPCI (58.6% vs 54.1%, p=0.38, in BB vs placebo, respectively) neither a significant difference was found for the percentages of patients in each of the four prespecified groups (normalised ST-segment; 1-3 mm; 4-6 mm;>6 mm residual ST-deviation).Conclusions In patients with STEMI, who were being transported for primary PCI, early IV BB administration did not significantly affect ST-segment deviation after pPCI compared with placebo. The neutral result of early IV BB administration on an early marker of pharmacological effect is consistent with the absence of subsequent improvement of clinical outcomes.</p
HDL cholesterol efflux normalised to apoA-I is associated with future development of type 2 diabetes: From the CORDIOPREV trial
No full textThis prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator. During follow-up 106 individuals progressed to T2DM. The cholesterol efflux/apoA-1 ratio was inversely associated with T2DM development independently of traditional risk factors (model-1, OR: 0.647, 95%CI: 0.495-0.846), and after additional adjustment for glycaemic parameters (model-2, OR: 0.670, 95%CI: 0.511-0.878). When cumulative incidence of diabetes was analysed by quartiles of cholesterol efflux/apoA-I, incidence of T2DM was reduced by 54% in subjects who were in the higher cholesterol efflux/apoA-I quartile compared to subjects in the lowest quartile (p = 0.018 and p = 0.042 for model-1 and 2). Moreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher disposition index (β = 0.056, SE = 0.026; p = 0.035). In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely associated with T2DM development in cardiovascular patients. This association was independent of several T2DM risk factors, and may be related to a preserved beta-cell function. © 2017 The Author(s)
Radiopurity assessment of the energy readout for the NEXT double beta decay experiment
No full text[EN] The "Neutrino Experiment with a Xenon Time-Projection Chamber" (NEXT) experiment intends to investigate the neutrinoless double beta decay of 136Xe, and therefore requires a severe suppression of potential backgrounds. An extensive material screening and selection process was undertaken to quantify the radioactivity of the materials used in the experiment. Separate energy and tracking readout planes using different sensors allow us to combine the measurement of the topological signature of the event for background discrimination with the energy resolution optimization.
The design of radiopure readout planes, in direct contact with the gas detector medium, was especially challenging since the required components typically have activities too large for experiments demanding ultra-low background conditions. After studying the tracking plane, here the radiopurity control of the energy plane is presented, mainly based on gamma-ray spectroscopy using
ultra-low background germanium detectors at the Laboratorio Subterráneo de Canfranc (Spain).
All the available units of the selected model of photomultiplier have been screened together with most of the components for the bases, enclosures and windows. According to these results for the activity of the relevant radioisotopes, the selected components of the energy plane would give a
contribution to the overall background level in the region of interest of at most 2.4 × 10¿4 counts per keV, kg and year, satisfying the sensitivity requirements of the NEXT experiment.Special thanks are due to LSC directorate and staff for their strong support for performing the measurements at the LSC Radiopurity Service. We are really grateful to Grzegorz Zuzel for the radon emanation measurements. The NEXT Collaboration acknowledges support from the following agencies and institutions: the European Research Council (ERC) under the Advanced Grant 339787-NEXT; the Ministerio de Economia y Competitividad of Spain under grants FIS2014-53371-C04 and the Severo Ochoa Program SEV-2014-0398; the GVA of Spain under grant PROMETEO/2016/120; the Portuguese FCT and FEDER through the program COMPETE, project PTDC/FIS/103860/2008; the U.S. Department of Energy under contracts number DE-AC02-07CH11359 (Fermi National Accelerator Laboratory) and DE-FG02-13ER42020 (Texas A & and the University of Texas at Arlington.Cebrian, S.; Perez, J.; Bandac, I.; Labarga, L.; Álvarez-Puerta, V.; Azevedo, CDR.; Benlloch-Rodriguez, JM.... (2017). Radiopurity assessment of the energy readout for the NEXT double beta decay experiment. Journal of Instrumentation. 12. https://doi.org/10.1088/1748-0221/12/08/T08003S12Avignone, F. T., Elliott, S. R., & Engel, J. (2008). Double beta decay, Majorana neutrinos, and neutrino mass. Reviews of Modern Physics, 80(2), 481-516. doi:10.1103/revmodphys.80.481Martín-Albo, J., Muñoz Vidal, J., Ferrario, P., Nebot-Guinot, M., Gómez-Cadenas, J. J., … Cárcel, S. (2016). Sensitivity of NEXT-100 to neutrinoless double beta decay. Journal of High Energy Physics, 2016(5). doi:10.1007/jhep05(2016)159Renner, J., Farbin, A., Vidal, J. M., Benlloch-Rodríguez, J. M., Botas, A., Ferrario, P., … Borges, F. I. G. (2017). Background rejection in NEXT using deep neural networks. Journal of Instrumentation, 12(01), T01004-T01004. doi:10.1088/1748-0221/12/01/t01004Dafni, T., Álvarez, V., Bandac, I., Bettini, A., Borges, F. I. G. M., Camargo, M., … Conde, C. A. N. (2016). Results of the material screening program of the NEXT experiment. Nuclear and Particle Physics Proceedings, 273-275, 2666-2668. doi:10.1016/j.nuclphysbps.2015.10.024Cebrián, S., Pérez, J., Bandac, I., Labarga, L., Álvarez, V., Barrado, A. I., … Cárcel, S. (2015). Radiopurity assessment of the tracking readout for the NEXT double beta decay experiment. Journal of Instrumentation, 10(05), P05006-P05006. doi:10.1088/1748-0221/10/05/p05006Wang, X., Chen, X., Fu, C., Ji, X., Liu, X., Mao, Y., … Zhang, T. (2016). Material screening with HPGe counting station for PandaX experiment. Journal of Instrumentation, 11(12), T12002-T12002. doi:10.1088/1748-0221/11/12/t12002Barrow, P., Baudis, L., Cichon, D., Danisch, M., Franco, D., Kaether, F., … Wulf, J. (2017). Qualification tests of the R11410-21 photomultiplier tubes for the XENON1T detector. Journal of Instrumentation, 12(01), P01024-P01024. doi:10.1088/1748-0221/12/01/p01024Busto, J., Gonin, Y., Hubert, F., Hubert, P., & Vuilleumier, J.-M. (2002). Radioactivity measurements of a large number of adhesives. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 492(1-2), 35-42. doi:10.1016/s0168-9002(02)01280-9Nisi, S., Di Vacri, A., Di Vacri, M. L., Stramenga, A., & Laubenstein, M. (2009). Comparison of inductively coupled mass spectrometry and ultra low-level gamma-ray spectroscopy for ultra low background material selection. Applied Radiation and Isotopes, 67(5), 828-832. doi:10.1016/j.apradiso.2009.01.02
