703 research outputs found

    particleShear: Discrete Python particle simulation with digital rheology and stress tensor evaluation

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    particleShear: Python package for particle shear simulation This package provides a discrete particle simulation kit for having multiple spheres interacting. The spheres (i.e. 2D circles) interact by mutual elastic repulsion and tangential friction upon contact, but can also be crosslinked together. In addition to the elementary implementation of the interacting particles, it is also possible to define rheological experiments where the spheres are exposed to sinusoidally varying displacement conditions on the boundaries. We paid particular attention to avoid pitfalls that generate asymmetric stress tensors. Acknowledgement: Thanks from the author go to Fabien Bonini and Joé Brefie-Guth for package testing, and to Daniel Lyobenov for initial help with simulation setup. This repository archives the releases of the source code hosted at https://github.com/tbgitoo/particleShear. The package is available through the Python package server (see https://pypi.org/project/particleShear/1.0.2/). It can be installed automatically in python via pip3 install particleShear In some installations, the command may also be pip install particleShear; the minimal version of Python is 3.

    Optimizing construction of scheduled data flow graph for on-line testability

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    The objective of this work is to develop a new methodology for behavioural synthesis using a flow of synthesis, better suited to the scheduling of independent calculations and non-concurrent online testing. The traditional behavioural synthesis process can be defined as the compilation of an algorithmic specification into an architecture composed of a data path and a controller. This stream of synthesis generally involves scheduling, resource allocation, generation of the data path and controller synthesis. Experiments showed that optimization started at the high level synthesis improves the performance of the result, yet the current tools do not offer synthesis optimizations that from the RTL level. This justifies the development of an optimization methodology which takes effect from the behavioural specification and accompanying the synthesis process in its various stages. In this paper we propose the use of algebraic properties (commutativity, associativity and distributivity) to transform readable mathematical formulas of algorithmic specifications into mathematical formulas evaluated efficiently. This will effectively reduce the execution time of scheduling calculations and increase the possibilities of testability

    Dataset: Stability of hemicarbonate under cement paste-like conditions

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    Data, and scripts (analysis, plots) to go with the publication: Stability of hemicarbonate under cement paste-like conditions Fabien Georget (a,1,∗), Barbara Lothenbach (b) , William Wilson (a,c) , Franco Zunino (a) Karen L. Scrivener (a) a: aboratory of Construction Materials, LMC, EPFL-STI-IMX, Station 12, CH-1015 Lausanne, Switzerland b: Empa, Concrete & Asphalt Laboratory, Dübendorf, Switzerland c: Sherbrooke University, Sherbrooke, Quebec, Canada 1: current address: Institute of Building Materials Research, RWTH Aachen, Aachen, Germany * corresponding author To be submitted to Cement and Concrete Researc

    Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes

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    Copyright © 2004 Elsevier Inc. All rights reserved.Doublecortin (DCX) is a microtubule-associated protein involved in neuronal migration, which causes X-linked lissencephaly and subcortical laminar heterotopia (SCLH) when mutated. Here we show that DCX interacts with the ubiquitin-specific protease Drosophila fat facets related on X chromosome (DFFRX). This interaction was confirmed by targeted mutagenesis, colocalization, and immunoprecipitation studies. DFFRX is thought to deubiquitinate specific substrates including β-catenin, preventing their degradation by the proteasome. Interestingly, unlike β-catenin, no ubiquitinated forms of DCX could be detected, and indeed we show that DCX interacts with a novel recognition domain in DFFRX, located outside of its catalytic site. We also show that DFFRX associates with microtubules at specific subcellular compartments, including those enriched in DCX. These results thus suggest that in addition to vesicular trafficking, DCX may play a role in the regulation of cell adhesion via its interaction with DFFRX in migrating and differentiating neurons.Gaëlle Friocourt, Caroline Kappeler, Yoann Saillour, Fabien Fauchereau, Manuel S. Rodriguez, Nadia Bahi, Marie-Claude Vinet, Philippe Chafey, Karine Poirier, Shinichiro Taya, Stephen A. Wood, Catherine Dargemont, Fiona Francis and Jamel Chellyhttp://www.elsevier.com/wps/find/journaldescription.cws_home/622917/description#descriptio

    Vagabondage dans Le Mont Damion d’André Dhôtel

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    The paper discusses the theme of wandering in the novel by French author André Dhôtel. The protagonist of Le Mont Damion, Fabien Gort, is not a typical vagrant, as he is a member of an intellectual and quite rich family. However, because of his strong absent-mindedness and strangeness, Fabien is unable to find a place in social structures. People’s hostility leads him to many wanderings and unexpected encounters which influence his existence. The novel seems to be also a generic wandering, as it possesses some features of picaresque novel, adventure novel, initiation story and fairytale fantasy

    Early-life and chronic exposure to high-fat diet alters noradrenergic and glutamatergic neurotransmission in the male rat amygdala and hippocampus under cognitive challenges

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    OBEETEEN Consortium: Guillaume Ferreira, Gustavo Pacheco-Lopez, Etienne Coutureau, Ranier Gutierrez, Pascal Barat, Federico Bermudez-Rattoni, Gwenaelle Catheline, Claudia I. Pérez,, Pauline Lafenêtre, Daniel Osorio-Gomez, Kioko Guzman-Ramos, Fabien Naneix, Ernesto Sanz-Arigita, Ioannis Bakoyiannis. Note: Consortium author list recognizes the significant and irreducible commitment with the conceptualization, management, and realization of this research project.Peer reviewe

    The geology of the Ste. Justine map-area.

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    Following the discovery of copper-nickel mineralization in 1951 at St. Fabien de Panet, Montmagny County, about 50 miles east of Quebec City, the Quebec Department of Mines initiated a program of geological mapping in this area. In 1952, the author assisted Dr. J. Beland in the mapping of the St. Magloire area where the copper-nickel mineralization was discovered. [...

    Design, synthesis and organocatalytic activity of spiropyrazolidinones for iminium activation and organocatalytic H/D exchange reactions

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    Depuis les années 2000, le domaine de l’organocatalyse est en plein essor. Une vue d’ensemble des différents modes d’activation organocatalytique fera l’objet du premier chapitre. Malgré les avancées considérables faites dans l’activation par liaison covalente, particulièrement dans l’aminocatalyse par activation iminium, des progrès sont encore possibles au niveau de l’activité catalytique des organocatalyseurs. Une large partie du travail détaillé dans le deuxième chapitre concerne le design puis le développement de deux voies de synthèse permettant de préparer une nouvelle classe d’organocatalyseurs pour l’activation iminium ainsi que leurs tests d’activité catalytique. Enfin, le troisième chapitre est consacré à l’étude de réactions d’échange H/D organocatalysées par les carbènes N-hétérocycliques.Since the begining of 2000, the field of organocatalysis has performed a lot of improvements. An overview of the different modes of activation of this field will constitute the first chapter. Despite the improvements in the domain of activation by covalent bond, specially for the iminium activation, some enhancements of the catalytic activity of organocatalysts are still possible. A major part of the work developped in the second chapter will be focused on the design then the synthesis of a new class of organocatalysts for iminium activation and their catalytic activity tests. Then the third chapter will be dedicated to the H/D exchange reactions organocatalyzed by N-heterocyclic carbenes
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