1,721,152 research outputs found
Casadecó : plataforma online : compra y venta de muebles de segunda mano
Full text linkFil: Rodriguez, Daniela. Universidad de San Andrés. Escuela de Negocios; Argentina
Discovery of novel gut-derived <i>Klebsiella pneumoniae</i> phages and mucus-interacting gut phage proteins
No full textThe rise in antimicrobial resistance and the stagnation in antibiotic development have intensified interest in alternative therapies. Bacteriophages, viruses of bacteria, have significant potential, for both classical phage therapy and for microbiome modulation. Klebsiella pneumoniae is a high-risk pathogen due to its multidrug resistance and virulence, causing acute tissue infections as well as chronic gut colonisations that may drive other diseases, like inflammatory bowel disease (IBD). Consequently, Klebsiella phages are highly sought after, yet their therapeutic application is hindered by key gaps, including the lack of standardised accessible phage and strain collections, limited understanding of the roles of Klebsiella in IBD, and poor knowledge of phage ecology in the gut. To address these, this thesis showcases the establishment of KlebPhaCol, an open-source collection of 52 newly isolated Klebsiella phages and 74 Klebsiella strains, including clinical and reference strains. This resource includes gut-relevant phages infecting the IBD-associated K. pneumoniae ST323 strain and enables the centralised study of Klebsiella-phage interactions. It further explores the nematode Caenorhabditis elegans as a simple in vivo model for Klebsiella-driven gut inflammation, and investigates phage ecology within the intestinal mucosa, commonly disrupted in IBD. Our findings reveal genomic and functional features of KlebPhaCol, including the discovery of a novel phage family linked to the gut environment, Felixviridae. We also show Klebsiella induces intestinal distension in C. elegans, suggesting a tractable model for studying Klebsiella-driven inflammation. Finally, we uncover a repertoire of 6,302 putative phage-encoded mucus-interacting proteins, many with evidence of bacterial origin and plausible retained functionality as well as 390 hits derived from Klebsiella phages, offering insights on potential mechanisms by which Klebsiella spp. may achieve gut colonisation and contribute to disease. In conclusion, this thesis lays foundational resources and insights into Klebsiella-phage interactions, advancing phage therapy developments and deepening the understanding of phage ecology in the gut
On the instability of two entropic dynamical models
Full text linkIn this paper we study two entropic dynamical models from the viewpoint of information geometry. We study the geometry structures of the associated statistical manifolds. In order to analyse the character of the instability of the systems, we obtain their geodesics and compute their Jacobi vector fields. The results of this work improve and extend a recent advance in this topics studied in Peng et al.[13].Fil: Henry, Guillermo Sebastian. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas ; Argentin
The breakdown point of the median of means tournament
No full textThe median of means tournament estimator is known to have optimal properties since it achieves a sub-Gaussian performance for all random distributions with finite variance. In this work, we study the robustness of this estimator by computing its breakdown point.Fil: Rodriguez, Daniela Andrea. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; ArgentinaFil: Valdora, Marina Silvia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; Argentin
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Robust estimators in partly linear regression models on Riemannian manifolds
Full text linkUnder a partly linear model we study a family of robust estimates for the regression parameter and the regression function when some of the predictors take values on a Riemannian manifold. We obtain the consistency and the asymptotic normality of the proposed estimators. Simulations and an application to a real dataset show the good performance of our proposal under small samples and contamination.Fil: Henry, Guillermo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; ArgentinaFil: Rodriguez, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigaciones Matemáticas "Luis A. Santalo". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Matemáticas "Luis A. Santalo"; Argentin
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
