7,425 research outputs found
Soutenance de thèse: Vanessa Rodrigues
No full textAVIS de soutenance de Thèse ---- Madame Vanessa RODRIGUES Soutiendra sa thèse en Histoire, Histoire de l'Art et Archéologie le 16 décembre 2016 à 14h00 à l'UFR LLSHS - Salle du Conseil Directeurs de thèse : Monsieur François RECHIN Madame Hélène LE MEAUX Laboratoire :ITEM Sujet de la thèse : "Parures et échanges au premier âge du Fer, des Pyrénées à l'Atlantique (VIIIe-Ve siècles av. J.C.)
Soutenance de thèse: Vanessa Rodrigues
No full textAVIS de soutenance de Thèse ---- Madame Vanessa RODRIGUES Soutiendra sa thèse en Histoire, Histoire de l'Art et Archéologie le 16 décembre 2016 à 14h00 à l'UFR LLSHS - Salle du Conseil Directeurs de thèse : Monsieur François RECHIN Madame Hélène LE MEAUX Laboratoire :ITEM Sujet de la thèse : "Parures et échanges au premier âge du Fer, des Pyrénées à l'Atlantique (VIIIe-Ve siècles av. J.C.)
J.C. Steyn Collection index
No full textThis index describes the J. C. Steyn collection which includes background material for 3 biographies by J.C. (Jaap) Steyn namely N.P. van Wyk Louw, P.J. Cillié and MER (M.E. Rothman). Prof. J.C. Steyn (1939-) is an educationist, linguist and author. Correspondence ; clippings ; photographs ; book reviews ; articles ; speeches ; varia compiled in 23 pamphlet boxes
Product Innovation Knowledge Transfer for Developing Countries: Towards a systematic Transfer Approach
No full textThe transfer of knowledge on product innovation to small- and medium-sized enterprises and local knowledge institutions in developing countries is expected to be one of the key drivers for competiveness and economical growth, and a part of the solution to environmental and social challenge. In that respect, this PhD study focuses on how the process of the current knowledge transfer takes place and how it can be improved. A combination of literature review and empirical research has resulted into a conceptual framework to describe the complex and dynamic process of product innovation knowledge transfer to developing countries. In order to improve this process, a systematic approach has been developed and operationalized by a needs assessment tool and a design manual: The UNEP Design for Sustainability for Developing Economies (D4S-DE) Manual (www.d4s-de.org). Both tools have been tested in practice by practitioners and have been evaluated by an academic review board.Design EngineeringIndustrial Design Engineerin
Neuromuscular Activity Of Batx, A Presynaptic Basic Pla2 Isolated From Bothrops Alternatus Snake Venom
No full textWe have previously isolated a Lys49 phospholipase A2 homolog (BaTX) from Bothrops alternatus snake venom using a combination of molecular exclusion chromatography and reverse phase HPLC and shown its ability to cause neuromuscular blockade. In this work, we describe a one-step procedure for the purification of this toxin and provide further details of its neuromuscular activity. The toxin was purified by reverse phase HPLC and its purity and molecular mass were confirmed by SDS-PAGE, MALDI-TOF mass spectrometry, amino acid analysis and N-terminal sequencing. BaTX (0.007-1.4 μM) produced time-dependent, irreversible neuromuscular blockade in isolated mouse phrenic nerve-diaphragm and chick biventer cervicis preparations (time to 50% blockade with 0.35 μM toxin: 58 ± 4 and 24 ± 1 min, respectively; n = 3-8; mean ± S.E.) without significantly affecting the response to direct muscle stimulation. In chick preparations, contractures to exogenous acetylcholine (55 and 110 μM) or KCl (13.4 mM) were unaltered after complete blockade by all toxin concentrations. These results, which strongly suggested a presynaptic mechanism of action for this toxin, were reinforced by (1) the inability of BaTX to interfere with the carbachol-induced depolarization of the resting membrane, (2) a significant decrease in the frequency and amplitude of miniature end-plate potentials, and (3) a significant reduction (59 ± 4%, n = 12) in the quantal content of the end-plate potentials after a 60 min incubation with the toxin (1.4 μM). In addition, a decrease in the organ bath temperature from 37 °C to 24 °C and/or the replacement of calcium with strontium prevented the neuromuscular blockade, indicating a temperature-dependent effect possibly mediated by enzymatic activity. © 2009 Elsevier Inc. All rights reserved.1502291297Abreu, V.A., Dal Belo, C.A., Hernandes-Oliveira, S.S., Borja-Oliveira, C.R., Hyslop, S., Furtado, M.F., Rodrigues-Simioni, L., Neuromuscular and phospholipase activities of venoms from three subspecies of Bothrops neuwiedi (B. n. goyazensis, B. n. paranaensis and B. n. diporus) (2007) Comp. Biochem. Physiol. A Mol. Integr. Physiol., 148, pp. 142-149Acosta de Pérez, O., Koscinczuk, P., Negrette, S., Sánchez Negrette, M., Teibler, P., Ruiz, R., Efectos del veneno de Bothrops alternatus de Argentina sobre músculo y distintos organos de ratones (1996) Acta Physiol. Pharmacol. Ther. Latinoam., 46, pp. 97-102Borja-Oliveira, C.R., Durigon, A.M., Vallin, A.C., Toyama, M.H., Souccar, C., Marangoni, S., Rodrigues-Simioni, L., The pharmacological effect of Bothrops neuwiedii pauloensis (jararaca-pintada) snake venom on avian neuromuscular transmission (2003) Braz. J. Med. Biol. Res., 36, pp. 617-624Borja-Oliveira, C.R., Kassab, B.H., Soares, A.M., Toyama, M.H., Giglio, J.R., Marangoni, S., Re, L., Rodrigues-Simioni, L., Purification and N-terminal sequencing of two presynaptic neurotoxic PLA2, neuwieditoxin-I and neuwieditoxin-II, from Bothrops neuwiedi pauloensis (jararaca pintada) venom (2007) J. Venom. Anim. Toxins incl. Trop. Dis., 13, pp. 103-121Bülbring, E., Observations on the isolated phrenic nerve diaphragm preparation of the rat (1946) Br. J. Pharmacol., 1, pp. 38-61Chang, C.C., Neurotoxins with phospholipase A2 activity in snake venoms (1985) Proc. Natl. Sci. Counc. Repub. China [B], 9, pp. 126-142Chang, C.C., Chen, T.F., Lee, C.Y., Studies of the presynaptic effect of β-bungarotoxin on neuromuscular transmission (1973) J. Pharmacol. Exp. Ther., 184, pp. 339-345Cintra, A.C., Marangoni, S., Oliveira, B., Giglio, J.R., Bothropstoxin-I: amino acid sequence and function (1993) J. Protein Chem., 12, pp. 57-64Cogo, J.C., Prado-Franceschi, J., Cruz-Höfling, M.A., Corrado, A.P., Rodrigues-Simioni, L., Effect of Bothrops insularis venom on the mouse and chick nerve-muscle preparation (1993) Toxicon, 31, pp. 1237-1247Cogo, J.C., Prado-Franceschi, J., Giglio, J.R., Corrado, A.P., Cruz-Höfling, M.A., Donato, J.L., Leite, G.B., Rodrigues-Simioni, L., An unusual presynaptic action of Bothrops insularis snake venom mediated by phospholipase A2 fraction (1998) Toxicon, 36, pp. 1323-1332Cogo, J.C., Lilla, S., Souza, G.H., Hyslop, S., de Nucci, G., Purification, sequencing and structural analysis of two acidic phospholipases A2 from the venom of Bothrops insularis (jararaca ilhoa) (2006) Biochimie, 88, pp. 1947-1959Costa, P.D., Toyama, M.H., Marangoni, S., Rodrigues-Simioni, L., Cruz-Höfling, M.A., Effects of Bothrops pirajai venom on the mouse extensor digitorum longus (EDL) muscle preparation (1999) Toxicon, 37, pp. 1143-1153Dal Belo, C.A., Leite, G.B., Toyama, M.H., Marangoni, S., Corrado, A.P., Fontana, M.D., Southan, A., Rodrigues-Simioni, L., Pharmacological and structural characterization of a novel phospholipase A2 from Micrurus dumerilii carinicauda venom (2005) Toxicon, 46, pp. 736-750de Roodt, A.R., Dolab, J.A., Dokmetjian, J.C., Litwin, S., Segre, L., Vidal, J.C., A comparison of different methods to assess the hemorrhagic activity of Bothrops venoms (2000) Toxicon, 38, pp. 865-873de Roodt, A.R., Litwin, S., Vidal, J.C., Hemorrhagic activity of Bothrops venoms determined by two different methods and relationship with proteolytic activity on gelatin and lethality (2003) Toxicon, 41, pp. 949-958Elmqvist, D., Quastel, D.M.J., Presynaptic action of hemicholinium at the neuromuscular junction (1965) J. 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(Eds), Sarvier/FAPESP, São PauloGutiérrez, J.M., Ownby, C.L., Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity (2003) Toxicon, 15, pp. 915-931Gutiérrez, J.M., Rucavado, A., Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage (2000) Biochimie, 82, pp. 841-850Gutiérrez, J.M., Rucavado, A., Escalante, T., Díaz, C., Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage (2005) Toxicon, 45, pp. 997-1011Hawgood, B.J., Smith, J., The presynaptic action of crotoxin at the murine neuromuscular junction [proceedings] (1977) J. Physiol., 266, pp. 91P-92PHawgood, B.J., Smith, I.C., The importance of phospholipase A2 in the early induction by crotoxin of biphasic changes in endplate potentials at the frog neuromuscular junction (1989) Toxicon, 27, pp. 272-276Hawgood, B.J., Smith, I.C., Strong, P.N., Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle (1988) Br. J. Pharmacol., 94, pp. 765-772Homsi-Brandeburgo, M.I., Queiroz, L.S., Santo-Neto, H., Rodrigues-Simioni, L., Giglio, J.R., Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin (1988) Toxicon, 26, pp. 615-627Kini, R.M., Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes (2003) Toxicon, 42, pp. 827-840Lomonte, B., Ângulo, Y., Calderón, L., An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action (2003) Toxicon, 42, pp. 885-901Maruñak, S.L., Acosta de Pérez, O., Ruíz de Torrent, R.M., Teibler, G.P., Koscinczuk, P., Sánchez Negrette, M., Actividades hemorrágica, edematizante, proteolítica y mionecrótica de venenos de Bothrops alternatus (víbora de la Cruz) (1999) Acta Physiol. Pharmacol. Ther. 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Where do we draw lines: professional relationship boundaries and the child and youth care practitioner
No full textThe question of professional relationship boundaries is a poignant one, in light of the many boundary grey-zones that are created by the variety of young people’s needs, practice settings and professional relationship contexts within the field of child and youth care. In order to support practitioners’ development of critical thought and awareness of professional boundaries, this paper applies a professional relationship boundaries conceptual framework to child and youth care work, and the literature is consulted to explore the impacts of boundary violations, influences on individual’s boundaries, cues to indicate blurring boundaries, and key strategies to maintain balanced boundaries
Anthropometry of the Beaver, Sekani, and Carrier Indians:
No full textby J.C. Boileau GrantBulletin (National Museum of Canada) ; 81. Bulletin (National Museum of Canada). Anthropological series. ; 18
J.C. Painter letter to Benjamin Lundy
No full textLetter from J.E. Painter to (presumably) Benjamin Lundy, answering a request for information about the history and operations of the Underground Railroad. Letter includes details of a story of an ex-slave transported on the Underground Railroad through Ohio and stories of the plight of other fugitive slaves crossing the Ohio River.
Benjamin Lundy (1789-1839) was a prominent Quaker abolitionist best known for his development of abolitionist periodicals. His "Genius of Universal Emancipation" was first published in 1821 from his home in Mt. Pleasant, Ohio, and enjoyed a wide circulation across the antebellum United States. In the 1820s, the young William Lloyd Garrison came to work for The Genius. Benjamin Lundy traveled widely seeking subscriptions to The Genius, giving talks about the anti-slavery movement, and observing and documenting the conditions of enslaved people across the Americas. He was also involved in the establishment of freed slave colonies in Mexico
Turbulent wakes of plates with non-equilibrium similarity scalings
No full textWe have conducted hot wire anemometry measurements of six different axisymmetric turbulent wakes which demonstrate the existence in all these wakes of non-equilibrium mean flow profile scalings and of the underlying self-preservation and non-equilibrium dissipation scalings. These mean flow profile scalings are different from those of all documented canonical boundary-free turbulent shear flows to date, all of which have been established for very far downstream regions
Energy dissipation and flux laws for unsteady turbulence
No full textDirect Numerical Simulations of spatially periodic unsteady turbulence show that the high Reynolds number scalings of the instantaneous energy dissipation rate and interscale energy flux at intermediate wavenumbers are qualitatively different from the well-known cornerstone scalings of equilibrium turbulence where and are time-dependent rms velocity and integral length-scales. Instead, they both scale as where and are length and velocity scales characterizing initial/overall unsteady turbulence conditions
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