1,720,977 research outputs found
Il potere disciplinare del datore di lavoro: prospettiva storica e sviluppi futuri
Full text linkL’elaborato affronta il tema dello sviluppo del potere disciplinare del datore di lavoro e la sua evoluzione storica, sino alle frontiere moderne della sua applicazione. Il mercato del lavoro è infatti in costante e continua evoluzione, con la conseguenza che le nuove tecnologie e la digitalizzazione rappresentano una rivoluzione con la quale il diritto del lavoro deve confrontarsi. L’obbiettivo della ricerca è stato quello di fornire un quadro chiaro e analitico di come si è evoluto nel tempo l’utilizzo del potere disciplinare del datore di lavoro, prendendo come chiave di riferimento un fattore assai rilevante all’interno delle nuove dinamiche dei rapporti di lavoro – come dimostra il diffondersi di una sempre più abbondante giurisprudenza a riguardo – ossia la rilevanza disciplinare dei comportamenti extra lavorativi adottati sui social network. La ricerca è partita dalle fondamenta teoriche della natura giuridica del potere disciplinare, del suo presentarsi come una prerogativa datoriale tesa a raggiungere un obbiettivo organizzativo; in seguito è stato definito il tema della rilevanza disciplinare delle condotte extralavorative messe in atto tramite i social network e quali risposte il diritto del lavoro abbia fornito e possa ancora fornire. L’utilizzo dei social network diviene quindi di grande interesse scientifico poiché permette di trarre diversi spunti: la rilevanza disciplinare della condotta adottata, le modalità di esercizio del potere disciplinare, la possibilità di sanzionare condotte nuove e non previste né da regolamenti interni né dalla contrattualistica collettiva. La logica conclusione di tale percorso, nato all’interno di un Dottorato multidisciplinare che non riguarda unicamente lo studio del diritto del lavoro, ha pertanto fornito una prospettiva decisamente pratico-gestionale, indirizzata a vagliare le pratiche aziendali volte a prevenire e fronteggiare i comportamenti abusivi tenuti dai lavoratori tramite i social network, con da ultimo un focus sulle social media policies
Pitfalls and artifacts in [18F]-FDG PET imaging in children with lymphoma
No full text: Positron emission tomography/computed tomography (PET/CT) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose ([18F]-FDG) is a well-established imaging tool in adult oncology and is increasingly utilized also in pediatric oncology due to its ability to combine functional and anatomic information, thereby enhancing diagnostic accuracy and improving patient management. However, [18F]-FDG uptake in children differs physiologically from adults, and this radiotracer is not tumor-specific, with uptake occurring in various benign conditions such as inflammation, infection, and trauma. Accurate interpretation of pediatric [18F]-FDG PET/CT requires comprehensive knowledge of the normal distribution of FDG in children, recognition of physiological variants, and awareness of common benign lesions and PET/CT-related artifacts. Misinterpretation can lead to unnecessary follow-up studies, suboptimal treatment decisions, and/or increased radiation exposure. This review discusses the typical patterns of physiologic [18F]-FDG uptake in children, common benign mimics of malignancy, and potential artifacts and pitfalls encountered in pediatric [18F]-FDG PET/CT imaging, focus especially on head and neck (lymph nodes), brown adipose tissue, bone marrow and thymus. By increasing familiarity with these patterns, this review aims to improve diagnostic confidence, reduce interpretive errors, and promote safer and more effective imaging practices in pediatric oncology
2-[18F]-FDG PET/CT role in detecting Richter's transformation of Chronic Lymphocytic Leukemia and predicting overall survival
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Emerging PET-radiotracers in cardiovascular, neuro-inflammation, lung and rheumatological diseases: a narrative review
No full textBackground: Imaging plays a crucial role in the clinical management of patients with inflammatory diseases, both for diagnosis and in evaluating treatment response. 2-deoxy-2-[18F]-fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) is a non-invasive imaging technique that is gaining prominence in the study of various infectious and inflammatory diseases. Advances in PET imaging technology, along with the development of new radiopharmaceuticals, have the potential to enhance the diagnostic accuracy of imaging in the evaluation of inflammation, allowing for the tracking of disease activity through mechanisms distinct from FDG. Methods: This narrative review aims to explore and discuss the emerging role of new PET/CT radiopharmaceuticals in the field of inflammation taking into account findings from recent studies in this setting. Results: Preliminary promising findings are available in the literature regarding the potential usefulness of new radiotracers for investigating inflammatory diseases, especially in cardiovascular, neurological, rheumatological and pulmonary fields. In cardiovascular inflammation, different radiopharmaceuticals showed promising roles according to the disease evaluated, but globally the findings are preliminary and heterogeneous. Concerning cardiac sarcoidosis, somatostatin Receptor Subtype 2 (SSTR2)-ligands, translocator protein (TSPO) radiotracers, and hypoxic radiotracers were investigated but until now so strong evidence were available. About vasculitis, SSTR2-ligands and CXCR4 radiotracers showen the most promising findings, especially in the evaluation of treatment response. Regarding atherosclerosis and mycoarditis, we have positive preclinical studies but lack of evidence from a clinical point of view. For neuroinflammation, the available findings on new PET radiotracers are still limited even if TSPO PET seems the most promising due to the ability to image microglial activation. Instead, about lung and rheumatological inflammatory diseases, fibroblast activation protein inhibitors (FAPI) appear to be the most promising radiopharmaceutical, even better than [18F]FDG, although further solid data are needed. Conclusions: Emerging PET radiotracers showed promising results in detecting inflammatory diseases in different anatomical sites, but more robust and comprehensive studies are required for their clinical use
Radioguided lung lesion localization: introducing a fluoroscopy system in a SPECT/CT scan
No full textThe purpose was to report our experience in the use of radiotracer localization and resection of small, indistinct, or nonpalpable pulmonary lesions. We developed an innovative technique implementing a fluoroscopy system on a single-photon emission computed tomography/computed tomography (SPECT/CT) scan that allowed to perform CT-guided injection of radiotracer directly on SPECT/CT
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma
No full textPrimary brain lymphoma is an aggressive extranodal non-Hodgkin lymphoma with poor prognosis. Many possible prognostic factors are investigated with controversial results, but possible prognostic role of 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features remains unclear. Our aim was to study the metabolic behavior of brain lymphoma at 18F-FDG PET/CT and the prognostic impact of qualitative and semiquantitative PET/CT parameters
Clinical and prognostic role of detection timing of distant metastases in patients with differentiated thyroid cancer
No full textDistant metastases (DM) from DTC occur in 5-25% of cases and are correlated to lower survival; the prognostic significance of the temporal onset of DM is unclear. Our aim was to retrospectively analyze the prevalence of DM and to assess the prognostic role of the timing of manifestation of DM regarding the outcome
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