170,222 research outputs found
La déflexivité dans les langues d'Europe: Conclusion
No full textConclusione del volume "La déflexivité dans les langues d'Europe"Conclusion of the book "La déflexivité dans les langues d'Europe"Conclusion du volume "La déflexivité dans les langues d'Europe
La déflexivité dans les langues d'Europe: Introduction
No full textIntroduzione al volume "La déflexivité dans les langues d'Europe"Introduction to the book "La déflexivité dans les langues d'Europe"Introduction au volume "La déflexivité dans les langues d'Europe
La déflexivité, du latin aux langues romanes : les méchanismes systémiques en diachronie
No full textLa deflessività è un meccanismo che può essere osservato nell'evoluzione delle lingue flessive. Questo è in particolare il caso dell'evoluzione delle lingue dal latino alle lingue romanze. Il fenomeno generalizzato della deflessività ha estratto dal nome come dal verbo un gran numero di marche morfologiche che subiscono una sorta di "decompattamento". Il francese è la lingua romanza che si è evoluta maggiormente in questa direzione diventando una lingua analitica con forti caratteristiche "neoisolanti".Deflexivity is a mechanism that can be observed in the evolution of flexional languages. This is particularly the case of the evolution of Latin to Romance languages. The generalized phenomenon of the deflexivity extracted from the noun as from the verb a large number of morphological marks which undergo a kind of "unpacking". French is the Romance language that has evolved the furthest in this direction by becoming an analytic language with strong "neo-isolating" characteristics.La déflexivité est un mécanisme que l'on peut observer dans l'évolution des langues de type flexionnel. C'est tout particulièrement le cas de l'évolution du latin aux langues romanes. Le phénomène généralisé de la déflexivité a extrait du nom comme du verbe un grand nombre de marques morphologiques qui subissent une sorte de "décompactage". Le français est la langue romane qui a évolué le plus loin dans ce sens en devenant une langue analytique avec de fortes caractéristiques "néo-isolantes"
Towards a greener future: The role of sustainable methodologies in metabolomics research
No full textSustainability is a growing priority in scientific research, and metabolomics is no exception. Traditional metabolomics workflows rely on hazardous solvents, raising concerns regarding their environmental impact. Recent advancements in green analytical chemistry lay the ground for the integration of eco-friendly approaches in metabolomics from matrix collections and pre-treatment, through sample preparation till data analysis. This review explores the current state of sustainable metabolomic workflows, with a particular focus on green sample preparation methods, solvent-free, low-solvent extraction techniques, and energy-efficient instrumental analysis. Computational advancements, including AI-driven models, machine learning-based semi-quantification, and predictive algorithms for solvent selection, further enhance sustainability by reducing resource consumption. The applicability of these approaches in metabolomic studies, particularly in plant and food research is explored. By integrating innovative green methodologies across all stages of metabolomic workflows, researchers can significantly reduce environmental footprints while maintaining analytical rigor
Bacterial growth and biological properties of Cymbopogon schoenanthus and Ziziphus lotus are modulated by extraction conditions
No full textThe present study aims to evaluate the antibacterial activity and biological properties of two traditional Saharian plants (Cymbopogon schoenanthus and Ziziphus lotus). The plant extracts were obtained by using a different combination of extraction methods (conventional vs. ultrasound-assisted) and solvents (water vs. ethanol:water (50:50, v/v)). The antioxidant profile, anti-inflammatory activity and impact on bacterial growth (foodborne and probiotic bacteria) of the obtained extracts were assessed. The plant species showed the hierarchically more important role in determining the biological properties of the extracts, followed by extraction solvent and extraction conditions. Conventional Z. lotus hydroethanolic extracts showed the highest total phenolic content (20.4 mg GAE/g), while Z. lotus ethanol extracts from ultrasound-assisted process presented the highest content of carotenoids (0.15 mg/g). In addition, ultrasound-assisted Z. lotus hydroethanolic extracts presented the highest in vitro radical scavenging activity, being 7.93 mmol Trolox/g. Multivariate analysis statistics (PCA) showed that both the extraction methodology and the solvent used strongly affected the bacterial growth. Z. lotus mainly decreased the growth rate of S. aureus and L. innocua. Interestingly, the aqueous extracts of this plant as well as those from C. schoenanthus, obtained by conventional extraction, significantly increased the growth rate and the maximal optical density of L. casei. Aqueous extracts of both Z. lotus and C. schoenanthus slightly influenced the growth of Bifidobacterium. Overall, the extracts of these plants showed selective activities with respect to pathogens and probiotic bacteria and may provide an advantage both in terms of antimicrobial and prebiotic activity
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Deprotonation of 3-Chloropropenyl-2-Oxazolines: Regio- and Stereochemistry of Reactions with Electrophiles
No full textMicrobiota metabolites: Pivotal players of cardiovascular damage in chronic kidney disease
No full textIn chronic kidney disease (CKD), cardiovascular (CV) damage is present in parallel which leads to an increased risk of CV disease. Both traditional and non-traditional risk factors contribute to CV damage in CKD. The systemic role of the microbiota as a central player in the pathophysiology of many organs is progressively emerging in the literature: the microbiota is indeed involved in a complex, bi-directional network between many organs, including the kidney and heart connection, although many of these relationships still need to be elucidated through in-depth mechanistic studies.The aim of this review is to provide evidence that microbiota metabolites influence non-traditional risk factors, such as inflammation and endothelial dysfunction in CKD-associated CV damage. Here, we report our current understanding and hypotheses on the gut-kidney and gut-heart axes and provide details on the potential mechanisms mediated by microbial metabolites. More specifically, we summarize some novel hypotheses linking the microbiota to blood pressure regulation and hypertension. We also emphasise the idea that the nutritional management of CKD should be redesigned and include the new findings from research on the intrinsic plasticity of the microbiota and its metabolites in response to food intake. The need is felt to integrate the classical salt and protein restriction approach for CKD patients with foods that enhance intestinal wellness. Finally, we discuss the new perspectives, especially the importance of taking care of the microbiota in order to prevent the risk of developing CKD and hypertension, as well as the still not tested but very promising CKD innovative treatments, such as postbiotic supplementation and bacteriotherapy.This interesting area of research offers potential complementary approaches to the management of CKD and CV damage assuming that the causal mechanisms underlying the gut-kidney and gut-heart axes are clarified. This will pave the way to the design of new personalized therapies targeting gut microbiota
- …
