212,391 research outputs found
Letter from Paul M. Roca on behalf of Carl Hayden to Ray E. Carr, Associated Civic Clubs of Southern Utah
No full textLetter from Paul M. Roca to Ray E. Carr on behalf of Carl Hayden politely declining his invitation
ROCA : un modelo de desarrollo. Proyectos 1991/1992
No full textLa ROCA (Réseau des Organisations Caféières Autogérées), qui rassemble, en mai 1991, 9 groupes de petits producteurs de café situés dans 3 localités de la zone de Xalapa-Coatepec (Mexique), et bénéficie de l'appui des techniciens du projet SARH/CIRAD et de la société d'Assistance Agronomique AAS, est basée sur une volonté d'action coordonnée dans les différents domaines qui font l'objet de ses 5 programmes : commercialisation, amélioration des usines de traitement, amélioration de la production, administration des exploitations, formation et communication. Ce document présente les succès de chaque programme, les priorités du réseau et, en annexes, les projets prévus dans le cadre des différents programme
A Roca Regina, a 707 m.
No full textBoExcursió del 1 al 3 de novembre de 1974. Itinerari: Ceillers (387 m.) – Riu Barcedana (440 m.) – Camí de les Cent Corbes (700 m.) – Ermita de Sant Salvador del Montsec o del Bosc (1.200 m.) - Tossal de les Torretes (1.677 m.) – Puig de Mira ��� Pallars- i – Urgell (1.684 m.) – Puig de Migjorn (1.595 m.) – Portella Blanca 81.404 m.) – Rúbies (1.141 m.) – Font de les Bagasses (360 m.) – Cellers (387 m.) – Roca Regina (707 m.) – Cellers (387 m.
Carta manuscrita de Josep Maria Batista i Roca a Bernard Lesfargues
No full textJ. M. Batista i Roca elogia la traducció i el pròleg d'Incerta glòria. Així mateix esmenta la crítica del PEN català a un Repertorio sobre literatura catalana publicat pel Ministeri d'Afers Exteriors espanyol, per la seva tendenciositat
El Montsià, al fons, des de Roca Roja (559 m.)
No full textBoExcursió del 4 i 5 de juny de 1977. Itinerari: Les Cases d'Alcanar (16 m.) - Roca Roja (559 m.) - Cim del Montsià (762 m.) - Coll de la Foradada - La Foradada (698 m.) - Mata-redona (570 m.) - Puig de Mata-redona (617 m.) - Camí de Freginals a Amposta - Amposta (10 m.) - El Delta de l'Ebr
Ermita de la Roca (280 m.) i capella de Sant Ramon (292 m.)
No full textBoItinerari: Mont-roig del Camp (111 m.) - Ermita de la Mare de Déu de la Roca (292 m.) - Serra de l'Areny (330 m.) - Vilanova d'Escornalbou (226 m.) - Escornalbou (650 m.) - L'Argentera (344 m.
Lo somni de Johan Johan.
No full textPrecedeix al tít.: "La present obra ha fet lo magnifich mossen jaume gaçull cavaller La qual es intitulada"Colofó (f. 100): "fuit impressu[m] in ciuitate[m] valentie. Per Lupum de roca alemanu[m]. Die. xxv. octobris. Anno domini. MD.cccc.xcvij"Signatures: A-F8, G10Tipus gòtics de dos mides, a 30 líniesGravats xilogràfics i caplletres gravadesFiligrana: mà i este
Tot el grup dalt de Roca Regina, a 707 m.
No full textBoExcursió del 1 al 3 de novembre de 1974. Itinerari: Ceillers (387 m.) – Riu Barcedana (440 m.) – Camí de les Cent Corbes (700 m.) – Ermita de Sant Salvador del Montsec o del Bosc (1.200 m.) - Tossal de les Torretes (1.677 m.) – Puig de Mira – Pallars- i – Urgell (1.684 m.) – Puig de Migjorn (1.595 m.) – Portella Blanca 81.404 m.) – Rúbies (1.141 m.) – Font de les Bagasses (360 m.) – Cellers (387 m.) – Roca Regina (707 m.) – Cellers (387 m.
Roca (Paul M.) Spanish Jesuit Churches in Mexico's Tarahumara
No full textHaubert Maxime. Roca (Paul M.) Spanish Jesuit Churches in Mexico's Tarahumara. In: Archives de sciences sociales des religions, n°53/2, 1982. p. 350
Role of rocA Polymorphisms on Virulence and Pathogenesis of Serotype M28 Group A Streptococcus
No full textGroup A Streptococcus (Streptococcus pyogenes, GAS) is a human-specific pathogen that causes a wide range of diseases and significant morbidity and mortality worldwide. Despite over a century of research, no licensed human vaccine exists to protect against GAS infection, which may be due, in part, to the complex regulation of its many virulence factors and surface exposed proteins. Several virulence regulators have been well described for GAS, including the CovRS (control of virulence regulator/sensor) two-component system. CovRS is a negative regulator of virulence in GAS. That is, CovS phosphorylates CovR to repress virulence gene expression. Whereas CovRS has been extensively studied over the past two decades, my research efforts have focused on RocA (regulator of Cov), an accessory protein to the CovRS two-component system. RocA is believed to interact with CovS to increase CovR phosphorylation, although the molecular mechanism of this phenomenon remains unknown.
Recent whole-genome population-based sequencing studies of serotype M28 GAS invasive disease clinical isolates identified an unusually high number of polymorphisms in rocA compared to other serotypes. Thus, I hypothesized that amino acid changes in RocA result in altered RocA-RocA and RocA-CovS protein interactions, giving rise to an altered global transcriptome and increased virulence in serotype M28 GAS. I used naturally occurring clinical isolates and constructed isogenic rocA GAS mutant strains for transcriptome sequencing (RNA-seq), in vitro virulence factor assays, and in vivo animal infection model studies. Additionally, I performed substituted cysteine accessibility method as applied to transmembrane orientation (SCAMTM) to determine the membrane topology of RocA and bacterial adenylate cyclase-based two-hybrid (BACTH) assays to study RocA protein-protein interactions.
My results demonstrate that deletion of rocA results in a significantly altered GAS transcriptome and significantly increased virulence in vivo. Naturally-occurring polymorphisms in rocA also altered the global GAS transcriptome and increased strain virulence. The observed virulence phenotypes are the result of altered RocA-RocA and RocA-CovS protein interactions. Taken together, the data add important new understanding of the molecular pathogenesis of RocA in serotype M28 GAS
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