174 research outputs found
International perspectives: Point-of-care chest ultrasound in the neonatal intensive care unit: An Italian perspective
No full textSupplemental Material - Correlation and Agreement Between the CO2 Gap Obtained From Peripheral Venous Blood and From Mixed Venous Blood in Mechanically Ventilated Septic Patients
No full textSupplemental Material for Correlation and Agreement Between the CO2 Gap Obtained From Peripheral Venous Blood and From Mixed Venous Blood in Mechanically Ventilated Septic Patients by Daniele Orso, Chiara Molinari, Giacomo Bacchetti, Victor Zanini, Valentina Montanar, Roberto Copetti, Nicola Guglielmo, and Tiziana Bove in Seminars in Cardiothoracic and Vascular Anesthesia</p
Politicas publicas, trabalho e fronteras nas fronteras do dereito, Notazioni introduttive
No full textLo scritto rappresenta la relazione introduttiva ad un convegno internazionale centrato sulla disciplina della immigrazione e del lavoro, analizzata, sotto l’aspetto normativo e giurisprudenziale, a livello nazionale ed europe
3,5-dicaffeoylquinic acid lowers 3T3-L1 mitotic clonal expansion and adipocyte differentiation by enhancing heme oxygenase-1 expression
No full textAdipogenesis is a complex process in which cell commitment and mitotic clonal expansion (MCE) are in-sequence crucial events leading to terminal adipocyte differentiation. The molecules able to block some key signals in this cascade can hamper adipogenesis becoming promising agents to counteract hyperplasia and hypertrophy of adipose tissue. Mono- and di-caffeoylquinic acid isomers are biologically active polyphenols, displaying in vitro and in vivo antioxidant, hepatoprotective, anti-diabetic and anti-obesity properties. Among these isomers, 3,5-dicaffeoylquinic acid (DCQA) has been reported to inhibit lipid accumulation in adipose cells more successfully than others. Thus, we investigated DCQA effects and molecular mechanisms on 3T3-L1 pre-adipocytes induced to differentiate with a hormonal cocktail (MDI). Oil Red O incorporation assessed that DCQA pre-treatment inhibited lipid accumulation in 3T3-L1 cells induced to differentiate for 10 days. At this time, an increased phosphorylation of both AMP-activated kinase and acetyl-CoA carboxylase, as well as a strong decrease in fatty acid synthase protein level, were registered by immunoblotting, thereby suggesting that DCQA treatment can reduce fatty acid anabolism in 3T3-L1 adipocytes. Furthermore, BrdU incorporation assay, performed 48 h after hormonal stimulation, revealed that DCQA treatment was also able to hinder the 3T3-L1 cell proliferation during the MCE, which is an essential step in the adipogenic process. Thus, we focused our attention on early signals triggered by the differentiation stimuli. In the first hours after hormonal cocktail administration, the activation of ERK1/2 and Akt kinases, or CREB and STAT3 transcription factors, was not affected by DCQA pre-treatment. Whereas 24 h after MDI induction, DCQA pre-treated cells showed increased level of the transcription factor Nrf2, that induced the expression of the antioxidant enzyme heme oxygenase 1 (HO-1). In control samples, the expression level of HO-1 was reduced 24 h after MDI induction in comparison with the higher amount of HO-1 protein found at 2 h. The HO-1 decrease was functional by allowing reactive oxygen species to boost and allowing cell proliferation induction at the beginning of MCE phase. Instead, in DCQA-treated cells the HO-1 expression was maintained at high levels for a further 24 h; in fact, its expression decreased only 48 h after MDI stimulation. The longer period in which HO-1 expression remained high led to a delay of the MCE phase, with a subsequent inhibition of both C/EBP-α expression and adipocyte terminal differentiation. In conclusion, DCQA counteracting an excessive adipose tissue expansion may become an attractive option in obesity treatment
Immediate versus delayed integrated point-of-care-ultrasonography to manage acute dyspnea in the emergency department
No full textBackground: Dyspnea is one of the most frequent complaints in the Emergency Department. Thoracic ultrasound should help to differentiate cardiogenic from non-cardiogenic causes of dyspnea. We evaluated whether the diagnostic accuracy can be improved by adding a point-of-care-ultrasonography (POC-US) to routine exams and if an early use of this technique produces any advantage. Methods: One hundred sixty-eight patients were enrolled and randomized in two groups: Group 1 received an immediate POC-US in addition to routine laboratory and instrumental tests; group 2 received an ultrasound scan within 1 h from the admission to the Emergency Department. The concordance between initial and final diagnosis and the percentage of wrong diagnosis in the two groups were evaluated. Mortality, days of hospitalization in Emergency Medicine department and transfers to other wards were compared. Sensitivity and specificity of the routine protocol and the one including ultrasonography for the diagnosis of the causes of dyspnea were also analyzed. Results: Eighty-eight patients were randomized in group 1 and 80 in group 2. The concordance rate between initial and final diagnoses was significantly different (0.94 in group 1 vs. 0.22 in group 2, p < 0.005). The percentage of wrong initial diagnosis was 5% in group 1 and 50% in group 2 (p < 0.0001). Conclusions: Adding POC-US to routine exams improves the diagnostic accuracy of dyspnea and reduces errors in the Emergency Department
Otimização matemática na decisão do planejamento da expansão de um sistema de 8 barras
No full textFil: Copetti Lima, Diomar Adonis. Universidade Federal de Santa Maria. Centro de Excelência em Engenharia e Sistemas de Potência; Brasil.Fil: Fabrin, Francisco Gasparin. Universidade Federal de Santa Maria. Centro de Excelência em Engenharia e Sistemas de Potência; Brasil.Fil: Bernardon, Daniel P. Universidade Federal de Santa Maria. Centro de Excelência em Engenharia e Sistemas de Potência; Brasil.Fil: Cabral, Roberto José. Universidad Nacional de Misiones. Facultad de Ingeniería; Argentina.Fil: Oliveira, Mario Orlando. Universidad Nacional de Misiones. Facultad de Ingeniería; Argentina.A necessidade de distribuir energia elétrica e manter a sua qualidade, faz com que empresas do setor elétrico estejam constantemente preocupadas com a configuração e expansão do Sistema Elétrico de Potência (SEP). Este trabalho visa apresentar uma metodologia para tomada de decisões, no que se refere a expansão do SEP, utilizando a otimização matemática. Será empregado para a simulação do SEP o software ANAREDE e o software Otimiza para a busca da
melhor decisão.The Necessity to distribute electrical energy and maintain its quality makes companies in the electric power industry constantly concerned about the Electric Power System(EPS)configuration and expansion.This work aims present decision making methodology, regarding the expansion of SEP,using mathematical optimization.The software ANAREDE will be used for SEP simulation and the software Otimiza Will Be used to search for the best decision
Despacho de geração com aplicação do método programação dinâmica
No full textUm dos grandes desafios das empresas distribuidoras de energia é manter o atendimento da demanda solicitadas por seus clientes. Desta forma o Operador Nacional do Sistema necessita realizar estudos complexos para atender a demanda de todo o sistema elétrico brasileiro. Desta forma se faz necessário o uso de ferramentas computacionais para auxiliar na tomada de decisão sobre o despacho de geração. Neste trabalho será utilizado o Método de Programação Dinâmica Determinística para ilustrar o comportamento das centrais geradoras frente a uma demanda (carga) solicitada pela rede.One of the great challenges that electricity distribution companies face is to constantly meet the demand of their customers. Thus, the National Electric System Operator (ONS) must carry out complex studies in order to satisfy the demand of the entire Brazilian electrical system, which requires the use of computational tools to assist in the decision making when it comes to the generation dispatch. In this work, the Deterministic Dynamic Programming (DDP) method is used to illustrate the behavior of generating plants in response to a certain demand (load) generated by the electrical network.Fil: Copetti Lima, Diomar Adonis. Universidade Federal de Santa Maria; BrasilFil: Fabrin, Francisco G.. Universidade Federal de Santa Maria; BrasilFil: Bernardon, Daniel P.. Universidade Federal de Santa Maria; BrasilFil: Oliveira, Mario Orlando. Universidad Nacional de Misiones; ArgentinaFil: Cabral, Roberto José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones; Argentin
Poderes Investigatórios do Ministério Público
No full textTCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.O presente trabalho de conclusão de curso de graduação aborda a possibilidade do Ministério Público proceder investigação criminal, em função de poderes implícitos, para formar sua convicção a fim de oferecer a Denúncia. Utiliza-se fundamentalmente a pesquisa bibliográfica como base de estudo sobre a existência do poder implícito de investigar, suas implicações, seus prós e contras. Por fim, estudam-se questões sobre a constitucionalidade do princípio se aplicado neste caso, bem como as posições doutrinárias a favor e contra. A importância do estudo está nas incessantes discussões a respeito do papel do Ministério Público como fiscal da lei e detentor do poder persecutório do Estado
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