1,721,000 research outputs found
Saturations of subalgebras, SAGBI bases, and U-invariants
No full textGiven a polynomial ring P over a field K, an element g∈P, and a K-subalgebra S of P, we deal with the problem of saturating S with respect to g, i.e. computing Satg(S)=S[g,g−1]∩P. In the general case we describe a procedure/algorithm to compute a set of generators for Satg(S) which terminates if and only if it is finitely generated. Then we consider the more interesting case when S is graded. In particular, if S is graded by a positive matrix W and g is an indeterminate, we show that if we choose a term ordering σ of g-DegRev type compatible with W, then the two operations of computing a σ-SAGBI basis of S and saturating S with respect to g commute. This fact opens the doors to nice algorithms for the computation of Satg(S). In particular, under special assumptions on the grading one can use the truncation of a σ-SAGBI basis and get the desired result. Notably, this technique can be applied to the problem of directly computing some U-invariants, classically called semi-invariants, even in the case that K is not the field of complex numbers
Computing inhomogeneous Groebner bases
No full textis paper we describe how an idea centered on the concept of self-saturation allows several improvements in the computation of Gröbner bases via Buchberger's Algorithm. In a nutshell, the idea is to extend the advantages of computing with homogeneous polynomials or vectors to the general case. When the input data are not homogeneous, we use as a main tool the procedure of a self-saturating Buchberger's Algorithm. Another strictly related topic is treated later when a mathematical foundation is given to the sugar trick which is nowadays widely used in most of the implementations of Buchberger's Algorithm. A special emphasis is also given to the case of a single grading, and subsequently some timings and indicators showing the practical merits of our approach
DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells
No full textComparison of the Sensitivity of Human and Rat Hepatocytes to the Genotoxic Effects of Metronidazole
No full text: Metronidazole (MNZ), an antiprotozoan and antibacterial agent, has been shown to yield DNA-damaging reactive species after nitroreductive biotransformation. The genotoxic effect of MNZ was studied in primary cultures of both rat and human hepatocytes. In millimolar concentrations MNZ produced DNA fragmentation, as measured by the alkaline elution technique, and unscheduled DNA synthesis, as evaluated by quantitative autoradiography, in rat hepatocytes. The amount of DNA damage was directly related to the dose and the length of exposure, was increased by hypoxia and GSH depletion, and was markedly reduced by inhibition of cytochrome P-450 activity. In the same experimental conditions human hepatocytes resulted constantly more resistant than rat hepatocytes to the genotoxic activity of MNZ. These findings suggest that the rat hepatocyte model might be an inappropriate predictor of nitroimidazoles genotoxicity
A case of 5-fluorouracil toxicity
No full textDihydrouracil (UH2)IUracil (U) ratio in plasma was determinated as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity. The purpose of the study was to investigate the relationship between the UH2IU plasma ratio and the variation of DPD gene (DPYD), associated with a deficiency of DPD activity, in a patient who developed a severe adverse reaction to 5-fluorouracil. Patients'plasma sample and those of 20 healthy volunteers, used as control, were analyzed. The plasma concentrations of UH2 and U were assayed by HPLC-UV. UH2IU plasma ratio of the patient was 4.31; the mean ± SD ofUH2IU plasma ratios in controls was 5.26 ± 2.08. The UH2IU ratio of the patient was lower than the mean values recorded from a reference population suggesting a reduction of DPD activity according to haplotype of the patient, previously identified
Correlation betwen induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue specific carcinogenic activity
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
