6,622 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
A la recherche du sentiment d'appartenance à une région ; une étude du cas bâlois
No full textZusammenfassung. — Regionales Zugehörigkeitsgefühl - Der Basler Raum. — Im Rahmen der laufenden Untersuchungen während unserer gemeinsamen Lehrveranstaltungen mit dem Geographischen Institut der Universität Freiburg i.Br. widmeten wir uns auch der Frage der regionalen Identität bei den Studenten der Universität Basel.
Nach dem Zufallsprinzip versandten wir einen fünfseitigen Fragebogen an 300 Studierende ; davon erhielten wir 102 beantwortete Exemplare zurück. Der verwendete Fragebogen enthält 13 Fragen (u.a. Kognitives Erfassen des Regio-Raumes, Selbsteinschätzung, Bewertung der eigenen Lebenssituation). Drei Viertel der Befragten wohnen gerne in der Regio ; 86 % besuchen mehr oder weniger regelmässig das Elsass oder Baden. Dabei sticht bei den Fahrten ins Elsass die Erholungsfunktion ins Auge. Die deutsche Nachbarschaft hingegen ist für einen Drittel der Befragten Ort der Begegnung mit Verwandten und Freunden. Für 68 % wäre das Elsass auch als potentieller Wohnort durchaus vorstellbar für Baden konnten sich allerdings lediglich 39 % erwärmen.
Mit Hilfe des semantischen Differentials versuchten wir die gefühlsmässige Einschätzung der Deutschen, Franzosen und Schweizer herauszufinden. Dieses an sich umstrittene Verfahren stiess bei einem « kritischen » Teil der befragten Studenten (39 %) auf deutlichen Widerstand, was als ein Novum zu werten ist, verglichen mit der Untersuchung von J. Berger (1974). Trotz dem eher negativen Image der Nordwestschweizer ist unter den Befragten ein deutlicher Abbau der Klischeebilder unserer Nachbarn zu verzeichnen !Summary. — Our study deals with the question of the Régional Identity of the students of Basle University. 102 persons were interviewed. Attendance in the Regio is low, however the importance of Alsace as a place to relax was clear.
68 % of those asked considered Alsace to be a potential domicile. Using the Semantic Differential Method, 39 % of the respondents gave no assessment of personal feelings towards the Germans, the French and the Swiss.
Coincidentally with a strong decline in cliché ideas about our neighbours there is an increase in the « negative image » of the Swiss from the North-West part of Switzerland.Simko Dusan, Ritzler Ch., Schwager St. A la recherche du sentiment d'appartenance à une région ; une étude du cas bâlois. In: Revue Géographique de l'Est. Tome 27, N°1-2, année 1987. Vécu et comportement transfrontaliers. pp. 119-121
Les diminutifs basques avec ch
No full textSe presentan formaciones similares a los diminutivos vascos con "ch" en España y América latina. Se dan ejemplosThe author introduces similar formations to the Basque diminutive "ch" in Spain and Latin America. Examples are provide
COUPLING OF THE C-H STRETCH TO LARGE-AMPLITUDE TORSION AND INVERSION MOTIONS: COMPARISON OF CHCH, CHOH AND CHNH
No full textAuthor Institution: Department of Polymer Science and Department of Chemistry, The University of Akron; Department of Chemistry, The University of Akron, OH 44325In each of the title molecules, torsional and inversion tunneling occurs between six equivalent minima. Coupling of these degrees of freedom to the CH stretch occurs via variation of the C-H stretching force constants as a function of the torsional () and inversion () angles. Maps of the couplings have been computed at the MP2/6-311++G(3df,2p) level. Both the single bond CH stretch force constants and the bilinear couplings between CH bonds are presented as a function of and . Although the torsional barriers differ by more than a factor of 20, the torsion-inversion-vibration coupling patterns are very similar for CHNH and CHCH. On the other hand, the torsion-inversion-vibration coupling in the charged species CHOH is much weaker
Reply to the Ch. Lagrange’s note
No full textThe author answers to a Ch. Lagrange’s note who refutes his theory on the diurnal nutation.L’auteur répond à une note de Ch. Lagrange qui réfute sa théorie sur la nutation diurne
NATURE OF TORSION-INVERSION COUPLING IN CHNH, CHOH AND CHCH
No full textAuthor Institution: Department of Chemistry, The University of Akron, OH; 44325-3601Two-dimensional torsion-inversion surfaces for methylamine, protonated methanol and ethyl radical were calculated and fit to a function containing a polynomial in the inversion angle() and trigonometric functions of the torsional angle(). Calculations were done at the B3LYP, MP2, and CCSD(T) levels with the 6-311++G(d,p) and 6-311++G(3df, 2p) basis sets and partial optimization. CHNH, CHOH and CHCH have G symmetry with 6-equivalent minima which are located by the various calculations at inversion angles 6.5 to 11; 42 to 45.5 and 52.5 to 55 degrees respectively on either side of planar. The three molecules have very different barriers to inversion ranging from no barrier for CHCH to 838 cm for CHOH to 1837 cm for CHNH. The dominant torsion-inversion coupling term in all cases has the form
Note about Mr. Ch. Lagrange’s recent communication
No full textThe author establishes a note about Mr. Ch. Lagrange’s communication on the Eulerian nutation period.L’auteur établit une note au sujet d’une communication de Ch. Lagrande sur la période de la nutation eulérienne
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Using δ¹³C-CH₄ and δD-CH₄ to constrain Arctic methane emissions
No full text© Author(s) 2016.We present a global methane modelling study assessing the sensitivity of Arctic atmospheric CH₄ mole fractions, δ¹³C-CH₄ and δD-CH₄ to uncertainties in Arctic methane sources. Model simulations include methane tracers tagged by source and isotopic composition and are compared with atmospheric data at four northern high-latitude measurement sites. We find the model's ability to capture the magnitude and phase of observed seasonal cycles of CH₄ mixing ratios, δ¹³C-CH₄ and δD-CH₄ at northern high latitudes is much improved using a later spring kick-off and autumn decline in northern high-latitude wetland emissions than predicted by most process models. Results from our model simulations indicate that recent predictions of large methane emissions from thawing submarine permafrost in the East Siberian Arctic Shelf region could only be reconciled with global-scale atmospheric observations by making large adjustments to high-latitude anthropogenic or wetland emission inventories
PROBING THE REACTION PATH OF CH + H CH CH + H AND ISOTOPOLOGUES
No full textZ. Jin, B. J. Braams, J. M. Bowman, J. Phys. Chem. A 110, 1569 (2006).A. B. McCoy, B. J. Braams, A. Brown, X. Huang., Z. Jin, J. M. Bowman, J. Phys. Chem. A 108, 4991 (2004).Author Institution: Department of Chemistry, The Ohio State University, Columbus; OH 43210Protonated methane has long been of interest to astrochemists due to its presumed importance as a reaction intermediate in the reaction involving CH + HD within the interstellar medium. Within the interstellar medium there is a nonstatistical H/D isotopic abundance observed for isotopologues of CH. While classical trajectory calculations have been performed dissociating CH and CHD into the fragments, CH + H, CHD + H and CH + HD{}, these calculations do not account for a large portion of the available energy being tied up in the zero point energy of the reactants and products. Earlier work in our group on CHD{} showed the deuterium atoms were localized to the CH group, rather than the H moiety. Classical calculations fail to account for this observed localization, instead showing full delocalization of D between both CH and H. With a quantum mechanical treatment, the energetics and wave functions will depend on which asymptotic channel is chosen, while in the classical treatment, these channels will be energetically equivalent. By performing Diffusion Monte Carlo simulations in Jacobi coordinates, we can constrain the distance between the CH and H subunits. Using this technique we have evaluated a one-dimensional reaction potential that includes the full anharmonic zero point energy in the remaining degrees of freedom and can determine how energetics of this reaction change upon partial deuteration of CH or H. We have also evaluated the probability amplitude associated with the wave functions that are obtained in the DMC simulations at various values of the reaction coordinate
Determining the need for an expanded fitness component in the Fire Science Program at Milwaukee Area Technical College
No full textIncludes bibliographical references
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