1,720,966 research outputs found
S100A1 gene therapy protects cardiomyocytes against pro-arrhythmogenic Ca2+ waves and after-contractions
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
S100A1 acts positive inotropic and prevents Ca2+ triggered after-contractions in a model of Engineered Heart Tissue
No full textThe small calcium (Ca2+) binding protein S100A1 is as a critical regulator of cardiomyocyte Ca2+ handling thereby enhancing cardiac performance in vivo and in vitro. Our previous studies demonstrated that the positive inotropic effects of S100A1 are due to enhanced Ca2+ transients and sarcoplasmic reticulum (SR) Ca2+ load in isolated adult cardiomyocytes. These effects are independent of and in addition to cAMP-dependent positive inotropic mechanisms. However, inotropic interventions come at the risk of arrhythmogenic diastolic Ca2+ leakage when the SR Ca2+ content exceeds the threshold for spontaneous diastolic Ca2+ release. In a more recent study we could demonstrate that enhanced Ca2+ transients after S100A1 overexpression are associated with a reduced incidence of diastolic Ca2+ sparks and Ca2+ waves. These results favor the assumption that S100A1 might reduce the diastolic RyR2 leak, thereby impeding the development of pro-arrhythmogenic events.
Thus, the aim of this work was to investigate the effect of S100A1 on diastolic Ca2+ handling and on the impact of Ca2+-triggered arrhythmias in a multicellular system. For this reason, the 3-dimensional tissue culture model of Engineered Heart Tissue (EHT) was chosen. Due to its syncytial architecture, EHT closely mimics functional alterations, intercellular communication and reverse remodeling of whole hearts in vivo despite eased handling and pharmacological as well as therapeutic manipulations.
Pharmacological stimulation of EHT with endothelin-1 resulted in a heart failure-like phenotype with strong impairment of contractile performance. Adenoviral-mediated S100A1 overexpression was able to rescue failing EHT and resulted in superior contractility in normal EHT. Triggered contraction abnormalities, referred to as after-contractions, were induced by Ca2+ and β-AR stimulation and served as a surrogate of SOICR (store-overload-induced-Ca2+-release). S100A1 overexpression significantly protected against Ca2+ and β-adrenergic receptor (β-AR) triggered after-contractions in normal and failing EHT. Despite persistent abnormal phosphorylation-dependent changes at the RyR2 and altered complex formation with accessory proteins, S100A1 overexpression enhanced S100A1/RyR2 stoichiometry, which seems to be key for S100A1’s effects, combining inotropic and anti-arrhythmic potency
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
S100A1 Prevents SR Ca2+ Leak and Protects Against Arrhythmias in Ventricular Cardiomyocytes
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