1,720,964 research outputs found
Die Rolle von Influx- und Effluxkanälen in der Prädiktion der therapiefreien Remission bei Patienten mit chronischer myeloischer Leukämie
Full text linkIn kürzlich publizierten Studien konnte gezeigt werden, dass bei CML-Patienten mit tiefem molekularem Ansprechen ein Absetzversuch der Tyrosinkinase Inhibitor (TKI)-Therapie unter bestimmten Voraussetzungen als sicher eingestuft werden kann. Als Prädiktoren für eine therapiefreie Remission gelten die vorherige Dauer der Therapie und die Dauer des tiefen molekularen Ansprechens. Alter, BCR-ABL Transkript-Level, Geschlecht und Risko-Scores hingegen scheinen keinen Einfluss auf die TFR zu haben. Darüber hinaus scheint das Immunsystem eine übergeordnete Rolle zu spielen, da die Anzahl von NK-Zellen und CD86+ dendritischen Zellen signifikant mit dem Erhalt der TFR korrelieren. Bislang wurde jedoch der Einfluss der Pharmakogenetik auf die TFR noch nicht analysiert. Die In- und Effluxkanäle ABCG2, ABCB1 und OCT1 sind bekannt für ihre Rolle in der CML Progression bzw. Resistenzentwicklung. In dieser Arbeit wurde anhand des ABCG2/ABCB1/OCT1-Transkript-Levels getestet, ob eine konstitutionelle Disposition für eine TFR bei CML Patienten besteht.
In unserer Kohorte haben 132 CML Patienten den TKI (davon 87% mit Imatinib in Erstlinientherapie) im Rahmen der EURO-SKI abgesetzt. Zum Zeitpunkt des Absetzens wurde die Expression von ABCG2, ABCB1 und OCT1 anhand absoluter Quantifizierung mittels Plasmidstandards (Referenzgen: GUSB) an Leukozyten-RNA aus dem peripheren Blut gemessen. Mittels der minimal p-value Methode und nach Bonferroni-Adjustierung wurden jeweils die signifikanten Cutoffs eruiert. Im Rahmen eines multivariaten Cox Regressionsmodel wurden die einzelnen Variablen auf ihre Unabhängigkeit bezüglich der TFR Prädiktivität hin getestet. Als Relapse wurde der Zeitpunkt des MMR Verlustes definiert.
Die teilnehmenden 132 CML Patienten wiesen in dieser Substudie eine TFR-Rate von 54% nach TKI-Absetzen auf. Die Cutoff-Analysen ergaben nur für den Effluxkanal ABCG2 eine signifikante Risikostratifizierung. Bei Patienten mit einem ABCG2/GUSB Transkript-Level über 4.5‰ (n=93) verbleiben 30 Monate nach Absetzen des TKI 47% in TFR. Bei Patienten mit einer ABCG2 Expression unter oder gleich 4.5‰ (n=39) beträgt die TFR-Rate 30 Monate nach Absetzen des TKI 67% (p=0.043). ABCB1 und OCT1 zeigen, im Gegensatz zu ABCG2, eine signifikant differentielle Transkriptexpression im Vergleich zu gesunden Probanden. ABCG2 war das einzige Transporter-Gen das in den Multivariatanalysen als unabhängiger Prädiktor verblieb. Im Cox Regressionsmodel hatten Patienten mit einem ABCG2 Cutoff über 4.5‰ ein zweifach erhöhtes Relapse-Risiko. Ein weiterer unabhängiger Prädiktor in der Multivariatanalyse, war die Transkriptvariante e13a2, welche auch eine signifikante Risikostratifizierung in Bezug auf Relapse erlaubte (p=0.015). Die e13a2 Transkriptvariante zeigte wie ABCG2 ein zweifach erhöhtes Relapse-Risiko (HR 1.90 versus 2.00, CI 1.05-3.70 versus 1.14-3.30).
Die Suche nach neuen Biomarkern bzw. potentiellen BCR-ABL-Surrogatmarkern wird zukünftige CML Forschungsinitiativen entscheidend prägen. ABCG2 und die Transkriptvariante e13a2 können vielversprechende Biomarker für ein zukünftiges molekulares TFR-Screening von CML Patienten sein
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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