6 research outputs found
Author response image 1. Correlation of phosphosites between biological replicates.
No full textNeurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles. While many of the proteins governing these processes are known, their regulation is only beginning to be understood. Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats. Using rigorous quantification, we identified 252 phosphosites that are either up- or downregulated upon triggering calcium-dependent exocytosis. Particularly pronounced were regulated changes of phosphosites within protein constituents of the presynaptic active zone, including bassoon, piccolo, and RIM1. Additionally, we have mapped kinases and phosphatases that are activated upon stimulation. Overall, our study provides a snapshot of phosphorylation changes associated with presynaptic activity and provides a foundation for further functional analysis of key phosphosites involved in presynaptic plasticity
Assessing E-commerce application using co-creation of value
No full textThis study is focused on assessing e-commerce applications in using co-creation of value. To achieve this aim, the author investigates the co-creation of value concepts which are implemented in successful e-commerce applications. A co-creation model is constructed in term of the DART building block principle. The value co-creation concepts of this model are implemented in a local e-commerce application and a prototype website is developed. Then a questionnaire is carried out to compare the new prototype website with the website of the local e-commerce company. Based on the results of the questionnaire, it is observed that the value co-creation applications are better applied in the prototype and the prototype is viewed much more positively. Through the prototype and questionnaire, the author shows that co-creation concepts can improve a local e-commerce websit
Echocardiographic Evaluation of Left and Right Ventricular Function in Patients with Coronary Slow Flow Syndrome: A Comparative Study
No full textThe Coronary Slow Flow Phenomenon is a syndrome of normal coronary anatomy and delayed progression of contrast medium through the coronary vessels. This research attempts to analyze and compare the systolic and diastolic function of the left and right ventricle in primary Slow Flow and Normal Coronary Flow.Two groups of primary Slow Coronary Flow (33 people) and Normal Coronary Flow (11 people) were included and the systolic and diastolic function of the ventricles was analyzed and compared between them.In the control group 18% of patients had mild and in the case group 24.2% mild, and 3.1% had moderate left ventricular diastolic dysfunction (P >0.05). The frequency distribution of the left and right ventricular systolic dysfunction was similar in the two groups.There was no statistically significant difference between two groups and in the association of cardiac dysfunction, it may be reasonable to investigate other causes
Erratum to: Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1
No full text⚘ Becoming-Minority: Subjectivity and Suprasubjectivity ☀ Mahmoud Reza Moghaddam Shad
No full textFollow the leads... and you will turn back in awe at the semiotic itinerary involved in the process of becoming.
This event, commented on by Susannah Ticciati (King’s College London) and chaired by Yulia Nikitenko (Institute for Philosophical Studies), is part of the activities of the 2022 International Open Seminar on Semiotics: a Tribute to John Deely on the Fifth Anniversary of His Passing, cooperatively organized by the Institute for Philosophical Studies of the Faculty of Arts and Humanities of the University of Coimbra, the Lyceum Institute, the Deely Project, Saint Vincent College, the Iranian Society for Phenomenology at the Iranian Political Science Association, the International Association for Semiotics of Space and Time, the Institute for Scientific Information on Social Sciences of the Russian Academy of Sciences, the Semiotic Society of America, the American Maritain Association, the International Association for Semiotic Studies, the International Society for Biosemiotic Studies, the International Center for Semiotics and Intercultural Dialogue, Moscow State Academic University for the Humanities and the Mansarda Acesa with the support of the FCT - Foundation for Science and Technology, I.P., of the Ministry of Science, Technology and Higher Education of the Government of Portugal under the UID/FIL/00010/2020 project.
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Mahmoud Reza Moghaddam Shad (PhD in Political Theory, the University of Tehran) is the Co-founder and a member of the Executive Board of the ISP - Iranian Society for Phenomenology, the Specialized Secretary of the IYP - Iranian Yearbook of Phenomenology, and a former member of the Intellectual Trends Group of the Center of Middle East Strategic Studies. His research interests are phenomenology of everyday life and politics, ressentiment, identity politics, minority politics, democracy theory, sociology of knowledge, and sociology of novel. His recent publishing are "Becoming Minority as a Revolutionary Act: An Introduction to the Idea of Minoritarian Democracy" (Quarterly Journal of Politics, 48 (3), 753-770, 2018), "The Image of Government in Iranian Fiction" (Quarterly Journal of Politics, Forthcoming), "Empathy and Deviation in Value-Perception: The Phenomenology of the Man of Ressentiment," (IYP, 1st volume, forthcoming), “Phenomenology of Everyday Life and Redefinition of The Political” (IYP, 2nd volume, forthcoming), "Ressentiment and the Promise of ISIL's Revenge: A Case Study of European Warriors," (in Modern Barbarism, ed. by Mahdokht Zakeri Qalam Research Institute, pp. 29-34, 2016).
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Susannah Ticciati is Professor of Christian Theology at King’s College London. She is author of Reading Augustine: On Signs, Christ, Truth and the Interpretation of Scripture (London and New York: T&T Clark, 2022), A New Apophaticism: Augustine and the Redemption of Signs (Leiden and Boston: Brill, 2013), and Job and the Disruption of Identity: Reading Beyond Barth (London and New York: T&T Clark, 2005).
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Homepage: https://www.uc.pt/fluc/uidief/io2s
Auditorium: https://www.uc.pt/fluc/uidief/io2s/auditorium
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Technical support assured by Robert Junqueira.
The cover image for the video was designed by Zahra Soltani
