18 research outputs found
Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome.
No full textDermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. This article reviews molecules that could be used as biomarkers for diagnosis and monitoring dermatomyositis disease activity
Puffy Hand Syndrome Revealed by a Severe Staphylococcal Skin Infection
No full textPuffy hand syndrome develops after long-term intravenous drug addiction. It is characterized by a nonpitting edema, affecting the dorsal side of fingers and hands with puffy aspect. Frequency and severity of the complications of this syndrome are rarely reported. Local infectious complications such as cellulitis can be severe and can enable the diagnosis. Herein, we report the case of a 41-year-old man who went to the emergency department for abdominal pain, fever, and bullous lesions of legs and arms with edema. Bacteriologic examination of a closed bullous lesion evidenced a methicillin sensitive Staphylococcus aureus. The abdomen computed tomography excluded deep infections and peritoneal effusion. The patient was successfully treated by intravenous oxacillin and clindamycin. He had a previous history of intravenous heroin addiction. We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. Puffy hand syndrome, apart from the chronic lymphedema treatment, has no specific medication available. Prophylactic measures against skin infections are essential
Case Report Puffy Hand Syndrome Revealed by a Severe Staphylococcal Skin Infection
No full textPuffy hand syndrome develops after long-term intravenous drug addiction. It is characterized by a nonpitting edema, affecting the dorsal side of fingers and hands with puffy aspect. Frequency and severity of the complications of this syndrome are rarely reported. Local infectious complications such as cellulitis can be severe and can enable the diagnosis. Herein, we report the case of a 41-year-old man who went to the emergency department for abdominal pain, fever, and bullous lesions of legs and arms with edema. Bacteriologic examination of a closed bullous lesion evidenced a methicillin sensitive Staphylococcus aureus. The abdomen computed tomography excluded deep infections and peritoneal effusion. The patient was successfully treated by intravenous oxacillin and clindamycin. He had a previous history of intravenous heroin addiction. We retained the diagnosis of puffy hand syndrome revealed by a severe staphylococcal infection with toxic involvement mimicking a four limbs cellulitis. Puffy hand syndrome, apart from the chronic lymphedema treatment, has no specific medication available. Prophylactic measures against skin infections are essential
Designing a stabilizer for camcorder
No full textСтатья посвящена актуальной на сегодняшний день проблеме: уменьшение угловых движений камеры для предотвращения смазывания изображения "экшн" камер, которые с каждым днем пользуются все большей популярностью. Рассмотрены различные методы стабилизации и разработана система стабилизации "экшн" камеры. В результате проведенного анализа технологий компенсирования колебаний камеры был найден наиболее подходящий способ стабилизации. Результатом работы стало конструирование стабилизатора для "экшн" камеры. Подробно рассмотрена конструкция спроектированного устройства, приведено описание всех элементов, использованных для создания данного прибора. Изложен принцип действия стабилизатора в трех основных режимах: режиме следования камеры за поворотом основания, режиме стабилизации камеры относительно заданного положения визирного луча и режиме ручного управления с помощью кнопок задающего устройства.The article is dedicated to a problem of today's current interest: the reduction of angular movements of acamera to avoid blurred images of action camera that nowadays becomes increasingly popular. In the paper it putstasks to consider the various methods of stabilization and to develop a system for stabilizing of action camera. Themost appropriate way for stabilization was found in the result of analysis of compensate technologies for camerashake. As a result, the stabilizer for the action camera was constructed. In the article, a design of projected device ischaracterized in details; there are descriptions of all elements used to create this device. The author presents theprinciple of operation of the stabilizer in three basic modes: a mode when the camera is following after the rotationof the base, a mode when the camera is stabilized in relation to a predetermined position of the sight ray and amode of manual control with using a setting device
Purifying Selection in Deeply Conserved Human Enhancers Is More Consistent than in Coding Sequences
No full text(c) 2014 De Silva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Plasma membrane of Beta vulgaris storage root shows high water channel activity regulated by cytoplasmic pH and a dual range of calcium concentrations
No full text© The Author [2006]. Published by Oxford University Press [on behalf of the Society for Experimental Biology].Plasma membrane vesicles isolated by two-phase partitioning from the storage root of Beta vulgaris show atypically high water permeability that is equivalent only to those reported for active aquaporins in tonoplast or animal red cells (Pf=542 µm s-1). The values were determined from the shrinking kinetics measured by stopped-flow light scattering. This high Pf was only partially inhibited by mercury (HgCl2) but showed low activation energy (Ea) consistent with water permeation through water channels. To study short-term regulation of water transport that could be the result of channel gating, the effects of pH, divalent cations, and protection against dephosphorylation were tested. The high Pf observed at pH 8.3 was dramatically reduced by medium acidification. Moreover, intra-vesicular acidification (corresponding to the cytoplasmic face of the membrane) shut down the aquaporins. De-phosphorylation was discounted as a regulatory mechanism in this preparation. On the other hand, among divalent cations, only calcium showed a clear effect on aquaporin activity, with two distinct ranges of sensitivity to free Ca2+ concentration (pCa 8 and pCa 4). Since the normal cytoplasmic free Ca2+ sits between these ranges it allows for the possibility of changes in Ca2+ to finely up- or down-regulate water channel activity. The calcium effect is predominantly on the cytoplasmic face, and inhibition corresponds to an increase in the activation energy for water transport. In conclusion, these findings establish both cytoplasmic pH and Ca2+ as important regulatory factors involved in aquaporin gating.Karina Alleva, Christa M. Niemietz, Moira Sutka, Christophe Maurel, Mario Parisi, Stephen D. Tyerman, and Gabriela Amode
Anti-programmed cell death protein 1 tolerance and efficacy after ipilimumab immunotherapy: observational study of 39 patients
No full textClinical and histologic features of Mycoplasma pneumoniae –related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes
No full textInternational audienceBackground: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniaee related EM have been poorly described in the literature. Objective: To highlight differences between M pneumoniae EM and noneM pneumoniae EM. Methods: This single-center, retrospective cohort study included all patients admitted to our dermatology department for EM during 2000-2015. We compared epidemiologic, clinical, and histologic data and follow-up for M pneumoniae EM and noneM pneumoniae EM cases. Results: Thirty-three patients with M pneumoniae EM were compared with 100 patients with noneM pneumoniae EM. Disease onset in winter was more frequent with M pneumoniae EM (P = .003). Acrally distributed lesions (32% vs 88%, P = 2) mucousal membrane involvement was more frequent in M pneumoniae EM than noneM pneumoniae EM (97% vs 60%; P Limitations: The retrospective design. Conclusion: M pneumoniae EM has a distinctive presentation compared with noneM pneumoniae EM, with more diffuse and atypical targets, more mucositis and respiratory tract sequelae. Histologic data show a TEN-like pattern in all M pneumoniae EM skin samples
Chemical characterization of inks in skin reactions to tattoo
No full textSkin reactions are well described complications of tattooing, usually provoked by red inks. Chemical characterizations of these inks are usually based on limited subjects and techniques. This study aimed to determine the organic and inorganic composition of inks using X-ray fluorescence spectroscopy (XRF), X-ray absorption spectroscopy (XANES) and Raman spectroscopy, in a cohort of patients with cutaneous hypersensitivity reactions to tattoo. A retrospective multicenter study was performed, including 15 patients diagnosed with skin reactions to tattoos. Almost half of these patients developed skin reactions on black inks. XRF identified known allergenic metals – titanium, chromium, manganese, nickel and copper – in almost all cases. XANES spectroscopy distinguished zinc and iron present in ink from these elements in endogenous biomolecules. Raman spectroscopy showed the presence of both reported (azo pigments, quinacridone) and unreported (carbon black, phtalocyanine) putative organic sensitizer compounds, and also defined the phase in which Ti was engaged. To the best of the authors’ knowledge, this paper reports the largest cohort of skin hypersensitivity reactions analyzed by multiple complementary techniques. With almost half the patients presenting skin reaction on black tattoo, the study suggests that black modern inks should also be considered to provoke skin reactions, probably because of the common association of carbon black with potential allergenic metals within these inks. Analysis of more skin reactions to tattoos is needed to identify the relevant chemical compounds and help render tattoo ink composition safer
Increased CD8+CD28- circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis
No full textInternational audienceNo abstract availabl
