1,720,975 research outputs found
Synergistic combination of fluoro chalcone and doxorubicin on HeLa cervical cancer cells by inducing apoptosis
No full textCHALCONES: THE PROMISING COMPOUNDS TO PROVIDE NEW WAYS FOR CANCER TREATMENT
No full textChalcones (1,3-diphenylpropen-1-ones), a biosynthetic product of the shikimate
pathway, belonging to flavanoid family are precursors of open chain flavonoids and
isoflavonoids, which are abundant in edible plants. They have a wide variety of
cytoprotective and modulatory functions, which may have therapeutic potential for
multiple diseases, especially as antitumor drugs. Several natural and synthetic chalcones
and their derivatives appear as promising anticancer activities. Their chemical structure
evaluation will be critical to assess their therapeutic utility. Those for which the
mechanism of action is well defined can serve as lead compounds for the design of new,
more promising molecules. The present review highlights the recently natural synthesized
chalcones and their derivatives possessing important pharmacological activities as
anticancer and how the mechanism pathways of these compounds in inhibiting cancer
cells
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
KAJIAN HUBUNGAN STRUKTUR DAN MEKANISME ANTIKANKER BEBERAPA SENYAWA MONO PARA HIDROKSI KALKON PADA SEL T47D
Full text linkTujuan jangka panjang dari penelitian ini adalah mengkaji hubungan struktur dan aktivitas senyawa mono para-hidroksi kalkon (MPHK) dan derivatnya sebagai antikanker. Target khusus yang ingin dicapai adalah mengkaji aktivitas antiproliferasi dan apoptosis dari senyawa-senyawa tersebut terhadap cancer cell lines payudara, yaitu sel T47D, meliputi : efek sitotoksis, pengaruhnya terhadap kinetika proliferasi, dan mekanisme antiproliferasinya, yaitu melalui cell cycle arest atau memacu terjadinya apoptosis.
Pada tahun pertama ini telah dilakukan pengumpulan senyawa mono para-hidroksi kalkon (MPHK) dan derivatnya dengan melakukan sintesis senyawa dari derivat benzaldehida dan asetofenon atau derivatnya melalui reaksi kondensasi aldol silang dalam suasana asam. Pemisahan dan pemurnian senyawa kimia dilakukan dengan teknik rekristalisasi dengan pelarut yang sesuai. Identifikasi dan elusidasi struktur dilakukan dengan membandingkan data kromatografi lapis tipis (KLT) pada berbagai eluen dengan senyawa yang telah ditemukan sebelumnya, dan menggunakan analisis data spektrum IR. Masing-masing senyawa selanjutnya dilakukan uji sitotoksisitasnya secara invitro terhadap sel T47D menggunakan metode MTT assay yang dibaca serapannya dengan microplate Elisa reader pada λ 595 nm dengan membandingkan serapan dari sel kontrol dan akibat penambahan perlakuan sampel pada berbagai konsentrasi. Pengamatan perubahan morfologi sel juga diamati menggunakan mikroskop fase kontras.
Hasil penelitian menunjukkan bahwa senyawa MPHK A, MPHK B, MPHK C, dan MPHK D memiliki aktivitas sitotoksik terhadap terhadap cancer cell line T47D, sedangkan senyawa MPHK E tidak memiliki aktivitas sitotoksik. Sifat toksisitas tertinggi dimiliki oleh MPHK A dengan harga LC50 sebesar 66,44 g/mL. Adanya gugus hidroksil memberikan kontribusi pada peningkatan sifat sitotoksik
PENGARUH p-HIDROKSI m-METOKSI KALKON (pHmMK) TERHADAP EKSPRESI PROTEIN Bcl-2 dan Bax PADA SEL KANKER PAYUDARA MCF-7
No full textSenyawa derivat kalkon yaitu 3-(4’-hidroksi-3’-metoksifenil)-1-fenil-2-propen-1-on) atau para hidroksi meta metoksi kalkon (pHmMK) telah diteliti mampu memacu apoptosis (kematian sel) pada sel kanker payudara MCF-7. Penelitian ini bertujuan untuk mempelajari jalur mekanisme apoptosis senyawa pHmMK pada sel kanker MCF-7 dengan mengamati pengaruhnya terhadap ekspresi protein Bcl-2 dan Bax. Pengamatan ekspresi protein dilakukan dengan metode imunositokimia (ICC) dan dianalisis menggunakan software ImageJ. Hasil penelitian menunjukkan bahwa pemacuan apoptosis oleh pHmMK terjadi melalui mekanisme penurunan ekspresi Bcl-2 dan peningkatan ekspresi Bax</jats:p
PELATIHAN TEKNOLOGI OLAHAN BAHAN PANGAN DARI BAHAN DASAR JAGUNG SEBAGAI ALTERNATIF WIRAUSAHA BAGI MASYARAKAT KURANG MAMPU DI DUSUN GEMBYONG, NGORO-ORO, KECAMATAN PATUK, KABUPATEN GUNUNG KIDUL
Full text linkAbstrak Kegiatan ini bertujuan untuk memberikan keterampilan tentang cara pengolahan jagung menjadi tortilla dan susu jagung di dusun Gembyong, Ngoro-oro, Patuk, Gunung Kidul. Pelaksanaan kegiatan dilakukan dengan metode penyuluhan dan pemberian keterampilan mengenai pembuatan tortilla dan susu jagung. Kegiatan dilaksanakan 2 (dua) kali dengan peserta adalah masyarakat kurang mampu. Hasil angket pada kegiatan pertama menunjukkan bahwa seluruh (100%) peserta menyatakan kegiatan ini bermanfaat, dan sebanyak 81,48% menyatakan kegiatan ini menambah wawasan tentang pengolahan produk makanan dari jagung. Secara keseluruhan kegiatan ini berhasil menambah wawasan dan keterampilan bagi peserta mengenai cara pembuatan tortilla dan susu jagung serta memotivasi peserta untuk mengembangkan wirausaha dengan keterampilan tersebut
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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