177,649 research outputs found
Surgical approaches in osteoarthritis: role of arthroscopy.
No full textHuman osteoarthritis (OA) is a heterogeneous and
multifactorial disease with multiple pathogenetic mechanism
implicated in its development and progression. Cartilage
degradation and loss are the major features of OA; degenerative changes include fibrillation, chondrocyte
proliferation into cell clusters, and matrix disruption. Although biomechanical factors are strongly implicated, it is
unclear which stimuli regulate the hyperactive phenotype of
OA chondrocytes, including their ability to express cartilage degrading proteinases. Recent studies have implicated the upregulation of several matrix-degrading metalloproteinases (MMPs) in OA cartilage and have suggested that chondrocyte production of MMPs in OA cartilage reflects local synthesis that varies with the extent of cartilage degeneration. The demonstration of chondrocytes producing interleukin-1 and tumor necrosis factor within the superficial zones of OA cartilage supports the concept that cytokine-MMP associations contribute to a highly catabolic state, chondrocyte apoptosis, and the resultant progressive degeneration of articular cartilage
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Intern experience at CH���M Hill, Inc.: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
A RETA TANGENTE NO LIVRO DO ENSINO M?DIO E DE C?LCULO: INVESTIGANDO RELA??ES DE ABORDAGEM
No full textEste trabalho tem por objetivo geral analisar a forma de abordagem da reta tangente em livros did?ticos de matem?tica do ensino m?dio e em livros de C?lculo do ensino superior, a fim de verificar se, ao introduzir o conte?do de derivadas, os conceitos e ideias da reta tangente estudados no ensino m?dio s?o retomados. Esta an?lise torna-se de cunho fundamental, pois n?o examina apenas a percep??o dos alunos, mas tamb?m a abordagem que os professores desenvolvem para promover um melhor aprendizado, atrav?s do livro did?tico, identificando algumas lacunas que podem ser superadas por meio do seu planejamento pedag?gico. A metodologia desta pesquisa ? de cunho qualitativa, com car?ter explorat?rio, pois envolve um levantamento bibliogr?fico em livros did?ticos do ensino m?dio (03) e livros de C?lculo do ensino superior (04), quanto ? abordagem da reta tangente. Os crit?rios utilizados para os livros do ensino m?dio, referem-se ?s bibliografias mais atuais, de acordo com o Programa Nacional do Livro Did?tico (PNLD) de 2016. J? nos livros do ensino superior, a sele??o foi feita de acordo com a indica??o de professores atuantes na ?rea e com o contato obtido, com os livros que utilizei para estudo, na disciplina de C?lculo, durante a minha gradua??o. Inicialmente, ? feito um estudo explorat?rio, trazendo uma reflex?o que abrange os conceitos existentes sobre a reta tangente, al?m de uma revis?o hist?rica dos principais matem?ticos que contribu?ram diretamente para a sua cria??o, de acordo com o trabalho de Faria (2018). Posteriormente, temos as an?lises dos livros did?ticos, onde ser?o expostas as percep??es desenvolvidas a partir das decorrentes an?lises, evidenciando tanto a parte descritiva, quanto a parte cr?tica e reflexiva de nossa pesquisa. Diante disso, podemos concluir que, nos livros do ensino m?dio, percebemos que a maior car?ncia est? na abordagem feita sobre a reta tangente, que se apresenta de forma pouco explorada, onde os autores poderiam ter trazido um contexto hist?rico, retomando os conceitos do coeficiente angular, afinal, n?o contextualizar historicamente a reta tangente faz com que n?o seja identificado o real valor que a reta possui para a matem?tica. J? nos livros de C?lculo percebemos que, n?o h? tanta rela??o desse conte?do no ensino m?dio, com a forma que ? trabalhado no ensino superior. A maioria dos livros n?o faz um paralelo para evidenciar o que o aluno aprendeu no ensino m?dio e o que ele ir? aprender no ensino superior. A import?ncia desse paralelo se d? ao fato de o aluno conseguir compreender a reta tangente em sua totalidade e perceber que o assunto que ele est? estudando, nada mais ? do que algo que ele j? viu, por?m, agora, de forma mais aprofundada. Fica a cargo do professor a responsabilidade de utilizar outros recursos para sanar essa dificuldade
Intern experience at the Texas Transportation Institute: an internship report
No full text"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirements for the degree of Doctor of Engineering."Includes vita (leaf 91)Includes bibliographical references (leaf 57)This report discusses the author's engineering experience at the Texas
Transportation Institute (TTI), Texas A&M University from March 1974 through July 1977. A
report of this experience plus twelve additional hours of academic course work were
substituted for an internship according to requirements established by the College of
Engineering. Although the author could not retroactively establish objectives of the type
associated with a typical internship, the work experience gained could be related to the two
general objectives of an intership: 1. To demonstrate an identifiable contribution to the
organization in which the intern served, and 2. To enable the intern to become aware of the
non-technical aspects of working as an engineer in a non-academic environment. While a member
of the Texas Transportation Institute staff, the author worked on a number of projects in the
areas of highway traffic engineering research and the preparation of continuing education
courses for transportation engineering officials. These assignments were contained within the
Urban Transportation Systems Division of TTI. This report delineates the author's contribution
to four particular projects and discusses the technical as well as non-technical experience
gained from each. Having been exposed to more engineering situations than many of the other
Doctor of Engineering students, the author has already formulated some rather specific
milestones for the future. The Doctor of Engineering program is discussed in conjunction with
its potential for helping the author attain these career goals and objectives. Also, some
thoughts are presented regarding the Doctor of Engineering as a viable alternative to the
Ph.D. in preparing for a career in engineering higher education
The long-wavelength view of GG Tau A: rocks in the ring world
No full textWe present the first detection of GG Tau A at centimetre wavelengths, made with the Arcminute Microkelvin Imager Large Array at a frequency of 16 GHz (λ = 1.8 cm). The source is detected at >6 σrms with an integrated flux density of S16GHz = 249 ± 45 µJy. We use these new centimetre-wave data, in conjunction with additional measurements compiled from the literature, to investigate the long-wavelength tail of the dust emission from this unusual protoplanetary system. We use an MCMC-based method to determine maximum likelihood parameters for a simple parametric spectral model and consider the opacity and mass of the dust contributing to the microwave emission. We derive a dust mass of Md ~ 0.1 Msun, constrain the dimensions of the emitting region and find that the opacity index at λ > 7 mm is less than unity, implying a contribution to the dust population from grains exceeding ~4 cm in size. We suggest that this indicates coagulation within the GG Tau A system has proceeded to the point where dust grains have grown to the size of small rocks with dimensions of a few centimetres. Considering the relatively young age of the GG Tau association in combination with the low derived disc mass, we suggest that this system may provide a useful test case for rapid core accretion planet formation models
Farmacologia e Infiltrazioni
No full textLo scopo della terapia dell’osteoartrosi è di ridurre il dolore, la rigidità e di miglio- rare la funzione. L’infiammazione accompagna spesso l’OA ed è appropriato consi- derare l’uso dei FANS come terapia di prima scelta. Minori rischi di eventi tossici gastrointestinali sono stati ottenuti dai farmaci inibitori selettivi della COX-2. Le altre terapie farmacologiche sono classificate in due classi: farmaci Symptom- modifying (SYSADOAs) e Disease-modifying (DMOADs). Il termine SYSADOA ha un significato generico e comprende farmaci come la Glucosamina Solfato, altri composti simili e l’Acido Ialuronico. La terapia intra-articolare con corticosteroidi dà un beneficio di breve durata. L’HA induce una remissione del dolore per diversi mesi e prove sperimentali dimostrano anche un ruolo disease-modifying sulle strut- ture articolari malate
Mejoramiento de la educación médica en la Universidad Nacional de Cuyo
No full textLa Universidad Nacional de Cuyo, después de un proceso de autoevaluación
en 1994-95, realizó un cambio curricular muy importante en su carrera de
medicina, que se inició en el ciclo lectivo 1997. Los principios que guiaron el
nuevo diseño curricular fueron: Enfoque científico-antropológico-social,
Integración, Significación, Flexibilización, Protagonismo en el aprendizaje y
Evaluación continua. El curriculum incluye: Cursos Biomédicos intensivos,
integrados por varias disciplinas y trabajado con la metodología de Aprendizaje
Basado Sobre Problemas; Cursos Longitudinales de formación humanística;
Rotaciones Clínicas intensivas y un año de Práctica Final Obligatoria en
internación, atención ambulatoria y emergencias.Fil: Reta de de Rosas, A. M..
Universidad Nacional de Cuyo. Facultad de Ciencias Médica
Intern experience at Honeywell, Inc., Large Information Systems Division: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical references (leaves 169-173)This report describes the author's internship assignment at Honeywell
Inc. - Large Information Systems Division from January, 1982 through August, 1982. The purpose
of the assignment was to fulfill the internship requirements of the Doctor of Engineering
Program. During the internship, the author held the position of VLSI design engineer, where he
worked on a predefined project. The project's objective was to evaluate how circuit designs
based on an advanced CMOS process, can be applied to hardware products at LISD. The internship
allowed the author to successfully apply the MOS circuit design training, which ws developed
at Texas A&M, to an industrial project. In addition, involvement in different activities
and exposure to the various problems not encountered in academia, made this internship an
invaluable experience
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