135 research outputs found
Epigenomic technologies: an interview with Jorg Tost
No full textInternational audienceJörg Tost received his PhD in genetics from the University of Saarbrücken (Germany) in 2004 for devising novel methods for the analysis of haplotypes and DNA methylation patterns. After a postdoctoral stay in the technology development department of the Centre National de Génotypage (Evry, France), he led the Epigenetics groups from 2006 to 2012, before becoming the Director of Laboratory for Epigenetics and Environment at the Centre National de Recherche en Génomique Humaine (CNRGH). The laboratory is involved in the development and application of technologies to analyze DNA methylation, miRNAs and other epigenetic modifications quantitatively at high resolution at target loci and genome-wide using state-of-the-art sequencing technologies as well as the development of bioinformatic tools for the processing of such data. The laboratory mainly focuses on the analysis of epigenetic changes in neurodegenerative, autoimmune and inflammatory diseases as well as the alteration of the epigenetic profiles in function of environmental exposure. A second research axis investigates novel technologies for the analysis of mutations of clinical relevance present at very low proportions in the analyzed samples and their impact on treatment management. Tost has an H-index of 50 and is the author or co-author of more than 195 publications
Run-Time Evolution through Explicit Meta-Objects
No full textSoftware must be constantly adapted due to evolving domain knowledge and unanticipated requirements changes. To adapt a system at run-time we need to reflect on its structure and its behavior. Object-oriented languages introduced reflection to deal with this issue, however, no reflective approach up to now has tried to provide a unified solution to both structural and behavioral reflection. This paper describes Albedo, a unified approach to structural and behavioral reflection. Albedo is a model of fined-grained unanticipated dynamic structural and behavioral adaptation. Instead of providing reflective capabilities as an external mechanism we integrate them deeply in the environment. We show how explicit meta-objects allow us to provide a range of reflective features and thereby evolve both application models and environments at run-time
REJOINDER TO BOETTKE ON COASEAN ECONOMICS AND COMMUNISM
No full textIn the view of Boettke (1998), Coase (1960) casts lights of understanding in a myriad of fields, including, preeminently, property rights theory and the Soviet system of economics. The claim of the present author, in sharp contrast, is that this seminal article of Coase’s is a snare and a delusion. It has led economists down a mistaken path for lo this past half century, and Boettke (1998) is but one more unfortunate example of this.Ronald Coase; Communism; Central Planning; Property Rights
Propulsion System Effects on the Controllability of a Second-Stage Spaceplane
No full textSpaceplanes are the future of space travel and launching objects into space. They are fully reusable, and provide a lot of flexibility to a mission. This thesis focuses on the propulsion system and its impact on the stability and control of a spaceplane. The main research question is: "Which parameters and deficiencies in the propulsion system of a winged second-stage spaceplane effect its controllability at single points during the hypersonic ascent phase?" To analyse propulsion effects, a dedicated propulsion model is developed to simulate the rocket engines of the vehicle. These engines are used for thrust vector control (TVC) of the vehicle. An incremental nonlinear dynamic inversion (INDI) controller is designed to study the controllability of the system. It is demonstrated that this INDI controller can effectively control the vehicle, even when subjected to thrust deficiencies, such as engine-out failures, engines getting stuck, thrust fluctuations and inertia shifts.Aerospace Engineerin
A blueprint to Monitor and Evaluate the impact of sustainability solutions in redevelopment projects of the public space: This research explores the possibilities for a system that monitors and evaluates the impact of sustainability solutions in redevelopment projects of the public space to identify the contribution to the stated sustainability ambitions
No full textMetropolitan Analysis, Design and Engineering (MADE
Multimodal Co-Presence Detection with Varying Spatio-Temporal Granularity
No full textPervasive computing environments are characterized by a plethora of sensing and communication-enabled devices that diffuse themselves among different users. Built-in sensors and telecommunication infrastructure allow co-presence detection. In turn, co-presence detection enables context-aware applications, like those for social networking among close-by users, and for modeling human behavior. We aim to support developers building better context-aware applications by a deepened understanding of which set of context information is appropriate for co-presence detection. We have gathered a multimodal dataset for proximity sensing, including several proximity verification sets, like Bluetooth, Wi-Fi, and GSM encounters, to be able to associate sensor's data with a spatial granularity. We show that sensor modalities are suitable to recognize the spatial adjacency of users with different spatio-temporal granularity. We find that individual user mobility has only a minor, negligible effect on co-presence detection. In contrast, the heterogeneity of device's sensor hardware has a major negative impact on co-presence detection. To reveal energy pitfalls with respect to usability, we perform an energy analysis pertaining to the usage stemming from different sensors for co-presence detection. Accepted Author ManuscriptInformation and Communication Technolog
Links between consumer protection law and competition law
No full textNamen tega prispevka je iskanje skupnih elementov konkurenčnega prava in pravne ureditve varstva potrošnikov. Avtor meni, da je zasebno pravo temelj tako konkurenčnega prava kot tudi prava varstva potrošnikov, in razvije teorijo, da je varovanje avtonomije volje pred nedovoljenimi posegi bistvo konkurenčnega prava in pravne ureditve prava potrošnikov. Avtor predlaga analizo ekonomskega pojma informacijske asimetrije kot pravne podlage obeh pravnih ureditev.The aim of this paper is the research of common elements of competition law and consumer protection law. The author considers that private law is the common legal basis of both competition law and consumer protection law and develops a theory under which the protection of the autonomy of parties to a contract against illicit influence is the aim of rules on competition and consumer protection. The author suggests an analysis of the economic notion of information asymmetry as legal basis for both set of rules
Povezave med pravno ureditvijo varstva potrošnikov in konkurenčnim pravom
No full textLinks between consumer protection law and competition law. The aim of this paper is the research of common elements of competition law and consumer protection law. The author considers that private law is the common legal basis of both competition law and consumer protection law and develops a theory under which the protection of the autonomy of parties to a contract against illicit influence is the aim of rules on competition and consumer protection. The author suggests an analysis of the economic notion of information asymmetry as legal basis for both set of rules.
Povzetek. Namen tega prispevka je iskanje skupnih elementov konkurenčnega prava in pravne ureditve varstva potrošnikov. Avtor meni, da je zasebno pravo temelj tako konkurenčnega prava kot tudi prava varstva potrošnikov, in razvije teorijo, da je varovanje avtonomije volje pred nedovoljenimi posegi bistvo konkurenčnega prava in pravne ureditve prava potrošnikov. Avtor predlaga analizo ekonomskega pojma informacijske asimetrije kot pravne podlage obeh pravnih ureditev
Assessing the ECB's Performance since the Global Slowdown A Structural Policy Bias Coming Home to Roost?
No full textThis paper assesses the ECB’s performance, which the author finds to be seriously lacking but which is of paramount importance to understanding euroland’s ongoing stagnation and fragility. A main finding is that the series of policy blunders which characterized the bank’s conduct features a bias. Institutions as well as personalities appear to be behind the bank’s tendency to err systematically in one direction. Curiously, this bias is adverse not only to growth, but to price stability. The author shows that viewing the ECB through inflation- targeting lenses is very misleading, since that view does not reflect the bank’s perspective at all, and that standard Taylor rule exercises are superfluous. The ECB’s words and deeds may be far more consistent than is widely held, without making them any less detrimental to economic performance.Policy inconsistencies, EMU, Inflation Targeting, Taylor rules
"Assessing the ECB's Performance since the Global Slowdown: A Structural Policy Bias Coming Home to Roost?"
No full textThis paper assesses the ECB's performance, which the author finds to be seriously lacking but which is of paramount importance to understanding euroland's ongoing stagnation and fragility. A main finding is that the series of policy blunders which characterized the bank's conduct features a bias. Institutions as well as personalities appear to be behind the bank's tendency to err systematically in one direction. Curiously, this bias is adverse not only to growth, but to price stability. The author shows that viewing the ECB through inflation-targeting lenses is very misleading, since that view does not reflect the bank's perspective at all, and that standard Taylor rule exercises are superfluous. The ECB's words and deeds may be far more consistent than is widely held, without making them any less detrimental to economic performance.
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