112 research outputs found
Our glorious dead [music] : memorial song to British Empire /
No full textCover title.; "This beautiful song should be sung on all memorial occasions it is dedicated to our heroes who fell in the great war".; Also available online http://nla.gov.au/nla.mus-an5528003; N, M 160818
The Critics : Rabbitt Like Pretty Automatons
No full textThe first article is a duplicate of an item forming part of hy-dm-news-reviews-michell-1977-001The article containing information about Brian Finch and Kenny Henson has been underlined in red pen.Item located in file hy-dm-finch-henson-1947-2007-001. Not all items in folder uploaded.The first article pertains to a concert featuring Rabbitt/ 5000 Volts and Brian Finch with Kenny Henson at the Film Trust Arena whereby the author reflects on all the musicians, points out the faults and provides praise where warranted. The second article refers to the same concert which took place at the Arena the previous evening. Apart from mentioning some commendable points of the evening, the author discusses the shortfalls attached to the Rabbitt performance and points out the similarities between the Henson and finch performance compared to their previous appearances
A strain tensor method for three-dimensional optimal Michell structures
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 94-95).In the design of discrete structures such as trusses and frames, important quantitative goals such as minimal weight or minimal compliance often dominate. Many numerical techniques exist to address these needs. However, an analytical approach exists to meet similar goals, which was initiated by A.G.M. Michell (1904) and has been mostly used for two-dimensional structures so far. This thesis develops a method to extend the existing mainly two-dimensional approach to apply to three-dimensional structures. It will be referred as the Michell strain tensor method (MSTM). First, the proof that MSTM is consistent with the existing theory in two dimensions is provided. Second, two-dimensional known solutions will be replicated based on MSTM. Finally, MSTM will be used to solve new three- dimensional cases.by Benjamin Jacot.M. Eng
Motor neuron differentiation in the developing and the regenerating adult spinal cord of zebrafish Danio rerio (Hamilton, 1822).
Get PDFZebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Spinal motor neurons are major targets for axons regenerating from the brainstem. Using immunohistochemical markers and transgenic reporter fish for motor neuron markers (H89, islet -1), this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and may be replaced by proliferation. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons, which were labelled by the proliferation marker bromodeoxyuridine, was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo -radial glial cells are the likely motor neuron progenitor /stem cells in the lesioned spinal cord. A spinal lesion increased expression of sonic hedgehog (shh), an embryonic differentiation signal for motor neurons. Blocking this signal with an antagonist reduced progenitor cell proliferation and motor neuron differentiation. This suggests that shh is an important signal for motor neuron differentiation during adult motor neuron regeneration.To learn more about axonal differentiation of motor neurons, the role of the cell recognition molecule plexinA3 was investigated during the outgrowth of embryonic primary motor axons. The molecule is selectively expressed in primary motor neurons. Knockdown of expression led to ectopic exiting from the spinal cord and excessive branching of motor axons. Over -expression of full length plexinA3 rescued this effect, indicating specificity of experimental manipulations. Thus, plexinA3 expression is crucial for motor axon pathfinding during development. Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor /stem cells and that shh is an important regulator of motor neuron regeneration. PlexinA3 is crucial for motor axon differentiation in embryonic zebrafish. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease
Motorneurondifferenzierung in Entwicklung und adulter Regeneration des Rückenmarks von Danio rerio (HAMILTON, 1822)
No full textIm Gegensatz zu Säugetieren besitzt der Zebrafisch die Fähigkeit zur funktionellen Rückenmarksregeneration. Dabei sind Motorneurone ein wichtiger postsynaptischer Zelltyp für Axone die vom Hirnstamm her regenerieren. Das Ziel dieser Arbeit war es zu analysieren, ob Motorneurone im lädierten Rückenmark regenerieren und die Differenzierungssignale für Motorneurone während der adulten Regeneration und der Embryonalentwicklung zu erforschen. Es konnte gezeigt werden, dass grosse, differenzierte Motorneurone nach einer kompletten Rückenmarksdurchtrennung vorübergehend verloren gehen und nach erfolgter Regeneration wieder nachweisbar sind. Um dies zu zeigen, wurden transgene Tiere mit Reportergenen für die Motorneuronmarker HB9 bzw. islet-1 und immunhistochemische Marker zur Darstellung von Motorneuronen verwendet. Diese Beobachtungen legen die Vermutung nahe, dass Motorneurone durch verletzungsbedingten Zelltod verloren gehen und dann im Zuge der Regeneration ersetzt werden. Tatsächlich kann eine transiente, massive Zunahme kleiner, undifferenzierter Motorneurone beobachtet werden. Mit Hilfe des Proliferationsmarkers Bromodeoxyuridine (BrdU) konnte nachgewiesen werden, dass diese undifferenzierten Motorneurone neu gebildet wurden. Eine signifikante verletzungsbedingete Prolifertation wurde nur am Ventrikel festgestellt. Ferner zeigte sich durch „lineage tracing“, dass eine olig2 exprimierende Subpopulation der ventrikulären Ependymo-Radialgliazellen die vermutlichen Stammzellen oder Progenitorzellen für Motorneurone im Rückenmark darstellen.
Eine Rückenmarksdurchtrennung im adulten Zebrafisch führt zu einer Erhöhung der Expression von sonic hedgehog (shh), einem Differenzierungssignal für Motorneurone während der Embryonalentwicklung. Intraperitoneale Injektion des shh -Antagonisten Cyclopamin während der Regeneration blockiert diesen Signalweg und führt zu einer signifikanten Reduktion der Proliferation von Progenitorzellen sowie der Motorneurondifferenzierung. Diese Ergebnisse legen den Schluss nahe, dass shh eine zentrale Rolle für die Regeneration von Motorneuronen im adulten Zebrafisch einnimmt.
Um die axonalen Differenzierung von Motorneuronen genauer zu erforschen, wurde die Funktion des Zellerkennungsmoleküls plexinA3 bei dem Auswachsen embryonaler primärer Motoraxone untersucht. Es konnte gezeigt werden, dass plexinA3 spezifisch von primären Motorneuronen exprimiert wird. Eine experimentelle Verringerung der Expression dieses Proteins mittels Injektion von anti-sense Morpholino-Oligonukleotiden bewirkt ein ektopisches Auswachsen aus dem Rückenmark sowie exzessives Verzweigen der Axone primärer Motorneurone. In einem “Rescue-Experiment” konnte durch Überexpression von plexinA3 der Morpholino-Effekt neutralisiert werden. Dies belegt die Spezifität der genetischen Manipulation und zeigt das plexinA3 äußerst wichtig für die axonale Wegfindung während der Entwicklung ist.
Abschließend kann festgestellt werden, dass der adulte Zebrafisch unter Kontrolle von shh zur Regeneration von Motorneuronen fähig ist. Als Quelle für diese neu entstehenden Motorneurone dienen endogene Progenitor- oder Stammzellen. Bei der axonalen Wegfindung von primären Motorneuronen während der Embryogenese spielt plexinA3 eine Schlüsselrolle. Die in dieser Arbeit gewonnen Erkenntnisse über Motorneuronendifferenzierung im Zebrafisch, können schlussendlich helfen, neue Strategien für die Regeneration von Motorneuronen nach Rückenmarksverletzungen oder Behandlungen für Erkrankungen der Motorneuronen, wie beispielsweise der amyotrophen Lateralsklerose, zu entwickeln.Zebrafish, in contrast to mammals, are capable of functional spinal cord regeneration. Spinal motor neurons are major targets for axons regenerating from the brainstem. Using immunohistochemical markers and transgenic reporter fish for motor neuron markers (HB9, islet-1), this study demonstrates that large differentiated motor neurons are transiently lost after a spinal lesion, suggesting that these cells undergo cell death after a lesion and may be replaced by proliferation. Indeed, a massive and transient increase in the number of small, undifferentiated motor neurons, which were labelled by the proliferation marker bromodeoxyuridine, was observed. Proliferation and lineage tracing studies indicated significant proliferation only at the spinal ventricle and that a subset of olig2 expressing ependymo-radial glial cells are the likely motor neuron progenitor/stem cells in the lesioned spinal cord.
A spinal lesion increased expression of sonic hedgehog (shh), an embryonic differentiation signal for motor neurons. Blocking this signal with an antagonist reduced progenitor cell proliferation and motor neuron differentiation. This suggests that shh is an important signal for motor neuron differentiation during adult motor neuron regeneration.
To learn more about axonal differentiation of motor neurons, the role of the cell recognition molecule plexinA3 was investigated during the outgrowth of embryonic primary motor axons. The molecule is selectively expressed in primary motor neurons. Knockdown of expression led to ectopic exiting from the spinal cord and excessive branching of motor axons. Over-expression of full length plexinA3 rescued this effect, indicating specificity of experimental manipulations. Thus, plexinA3 expression is crucial for motor axon pathfinding during development.
Overall, this study demonstrates that adult zebrafish are capable of motor neuron regeneration from endogenous progenitor/stem cells and that shh is an important regulator of motor neuron regeneration. PlexinA3 is crucial for motor axon differentiation in embryonic zebrafish. This study establishes adult spinal cord lesion as a model system for motor neuron regeneration, which may ultimately help to find ways to promote motor neuron regeneration also in human conditions, such as spinal cord injury or motor neuron disease
On the Possession of Truth in Fiction: A.S. Byatt's Confrontation with the Role of the Author
No full textWhen Possession’s protagonist, a post-structuralist/deconstructionist scholar named Roland Michell, finds and takes drafts of a letter written by Victorian poet Randolph Henry Ash, A.S. Byatt re-opens the longstanding debate concerning the ownership of truth and an author’s role in textual interpretation, ultimately asking: Who owns the meaning of a text? And even more so, why? The act of theft from the private world of an author (and the journey it spurs) allows Possession to coincide with pre-formalist notions about the author—that the author and their life is central to the meaning of their work—despite a dominant knowledge of formalism, new criticism, structuralism, poststructuralism, and deconstruction in the contemporary timeline. However, Possession’s three-and-a-half-page postscript chapter unravels a novel-length endorsement of pre-formalist notions, affording the novel a neutral existence that does not condemn nor encourage reliance on the biography of the author. As a result, this essay finds that the novel acts as a means for readers to identify two fundamental ideas about authorship and to witness a regressive transition from a post- to pre-formalist literary approach. In fact, by depicting the common occurrence of exchange to curate an author’s belongings (despite their passing), Possession even suggests that the reconfiguration of the author is a response to capitalist commodification. And so, by utilizing the theories of Roland Barthes and Michel Foucault, this essay argues how Possession shows the role of capitalism and consumerism in the contemporary approach to literature
Interactions between wavemaking and the boundary layer and wake of a ship model
No full textA detailed experimental study has been conducted in a towing tank on a 3.048-meter-long mathematical model, known as the Wigley hull, to study the effects of viscosity on the wavemaking resistance of the ship form. The measurements included total resistance, viscous resistance, pressure distribution, and boundary-layer measurements of the model at zero trim and sinkage. The three-dimensional boundary-layer measurements extend from midship to a distance of 0.1 model lengths downstream of the stern and include the pressure distribution on the body, and three components of the mean velocity measured by means of a five-hole pitot tube. These measurements were carried out for four Froude numbers of 0.266, 0.313, 0.350 and 0.400. A numerical method, using the small-crossflow approximation of the boundary-layer equations, has been employed to calculate the boundary-layer characteristics along the streamlines on the hull which were obtained by using Guilloton's methode A comparison between calculation and experimental results has been made. The wave-resistance coefficients of the ship form have been calculated by the Michell integral, using the Michell thin-ship centerplane distribution, a hull surface distribution and a slender-body centerplane distribution. These calculations have been carried out for two different cases, 1) wave resistance calculation without the effect of the boundary layer and wake, and 2) calculations including these effects. These calculations have been carried out only to first order and have been compared with the residuary resistance and the wave-profile resistance
A Goonful of Spike's Factory
No full textItem located in file hy-dm-parker-milligan-1976-1980-001Article includes an underlined section in red.The author of the newspaper article reflects on his first hand experience of a show hosted by Spike Milligan at the Colosseum. He raves about his talent and encourages readers to attend one of his performances. The article also mentions additional supporting acts which had greatly impressed the author
Museo Regional de Chiapas: Chiapas
No full textLa información de esta miniguÍa se basa en los datos disponibles a la fecha de publicación y en los trabajos de Eliseo Linares Villanueva, Ana María Rincón Montoya y Antonio García de León.• El Museo fue reinaugurado el 14 de septiembre de 1984 en la nueva y moderna construcción que hoy ocupa después de haber estado en edificios públicos, entre ellos la Biblioteca Pública del estado, el Palacio de la Cultura y el Instituto Botánico de Chiapas, edificio contiguo al lugar donde hoy se encuentra</p
Chondrolectin mediates growth cone interactions of motor axons with an intermediate target
Get PDFThe C-type lectin chondrolectin (chodl) represents one of the major gene products dysregulated in spinal muscular atrophy models in mice. However, to date, no function has been determined for the gene. We have identified chodl and other novel genes potentially involved in motor axon differentiation, by expression profiling of transgenically labeled motor neurons in embryonic zebrafish. To enrich the profile for genes involved in differentiation of peripheral motor axons, we inhibited the function of LIM-HDs (LIM homeodomain factors) by overexpression of a dominant-negative cofactor, thereby rendering labeled axons unable to grow out of the spinal cord. Importantly, labeled cells still exhibited axon growth and most cells retained markers of motor neuron identity. Functional tests of chodl, by overexpression and knockdown, confirm crucial functions of this gene for motor axon growth in vivo. Indeed, knockdown of chodl induces arrest or stalling of motor axon growth at the horizontal myoseptum, an intermediate target and navigational choice point, and reduced muscle innervation at later developmental stages. This phenotype is rescued by chodl overexpression, suggesting that correct expression levels of chodl are important for interactions of growth cones of motor axons with the horizontal myoseptum. Combined, these results identify upstream regulators and downstream functions of chodl during motor axon growth
- …
