2,690 research outputs found
Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells
No full textThe role of surfactant protein A (SP-A) in the recognition and clearance of apoptotic cells is well established, but to date, it is still not clear which surface molecules of apoptotic cells are involved in the process. Here we present evidence that phosphatidylserine (PS) is a relevant binding molecule for human SP-A. The binding is Ca2+-dependent and is not inhibited by mannose, suggesting that the sugar-binding site of the carbohydrate recognition domain (CRD) of SP-A is not involved. Flow cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells, and this was consistent for Jurkat cells and neutrophils. Supporting these data, confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic cells. However, we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface, as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface. <br/
Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D
No full textSurfactant proteins A (SP-A) and D (SP-D), both members of the collectin family, play a well established role in apoptotic cell recognition and clearance. Recent in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct manner. SP-A and SP-D bind in a Ca2+-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca2+-independent. Cell surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target molecules. Myeloperoxidase (MPO), a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis, was identified by affinity purification, mass-spectrometry and western blotting as a novel binding molecule for SP-A and SP-D. To confirm its role in recognition, it was shown that purified immobilised MPO binds SP-A and SP-D, and that MPO is surface-exposed on late apoptotic neutrophils. SP-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic cells. Fluorescence microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic neutrophils. Desmoplakin was identified as a further potential ligand for SP-A, and neutrophil defensin as a target for both proteins. <br/
The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms
No full textThe role of the lung surfactant proteins SP-A and SP-D in immune defence is well established. They bind to foreign organisms that invade the lungs and target them for phagocytic clearance by resident alveolar macrophages. SP-A and SP-D also bind to various apoptotic cells and facilitate their phagocytic uptake. To date, the molecular mechanisms by which the lung surfactant proteins interact with apoptotic cells and phagocytes are poorly understood.The aims of this study were to investigate further the interactions between SP-A and SP-D and apoptotic cells using human neutrophils and Jurkat cells as model systems.Specifically the binding behaviour of SP-A and SP-D with viable, early apoptotic and late apoptotic cells was investigated and compared. SP-A and SP-D show very distinct binding to the various cell types. SP-A bound to viable and early apoptotic cells in a predominantly Ca2+-dependent manner but the interaction with late apoptotic cells was Ca2+-independent, suggesting involvement of other than the lectin- or Ca2+-binding sites. This was consistent for neutrophils and Jurkat cells.SP-D in contrast, did not interact with viable and early apoptotic Jurkat cells but strongly and in a Ca2+-independent manner with late apoptotic Jurkat cells. SP-D-binding to viable and early apoptotic neutrophils was inhibited by maltose and ethylene-diamin-tetra-acetate (EDTA), suggesting lectin-binding site involvement whereas the binding to late apoptotic neutrophils was predominantly Ca2+-independent.These results represent a detailed study of the binding behaviour of SP-A and SP-D with different cell types and stages of viability. The mechanisms of these interactions appear to involve preferential recognition of different ligands on the apoptotic cell surface, which may include nucleic acid, phospholipid, protein and glycan structure
REID BROS, LTD / 101 /STANDARD SONGS / Tonic Solfa and Old Notation Combined_Full Pianoforte Accompaniments.
No full textTitle page: "E.T POTTER / Everything Musical / [... SALI]SBURY[?]" [stamp]Box no. 1Reid Bros: 101 Standard Songs; music printItem type: book | Content type: music and text | Counting of pages: page numbersvocal-instrumental score | staff notation; tonic sol-fa notation | voice; piano"Men of Harlech in the hollow, Do ye hear, like rushing billow [...]"March of the Men of Harlech (words by W.[illiam] Duthie); Giordani: Caro Mio Ben; Samuel Lover: Molly Bawn [from “Il Paddy Whack in Italia”]; W.[illiam] H.[erbert] Jude: Silvery Bells (words by W.[illiam] Cartwright-Newsam); Dr W[ilia]m Boyce: Heart of Oak (words by David Garrick); J. Louis Rockliffe and H.[enry] T.[emple] Leslie: The Four Jolly Smiths; Richard Wagner: Star of Eve [“O du mein holder Abendstern" from "Tannhäuser und der Sängerkrieg auf Wartburg”.]; C.M. von Weber: When the thorn is white with blossom (words by S.C.) [Lied der Hirtin]; Samuel Lover: The low back'd car; My love is like a red, red rose (Air "Low down in the broom.") (words by [Robert] Burns); Carl Monteith: Dream of Me (words by Clifton Bingham); Widdicome Fair; Scots wha hae; Kathleen O'Moore; Clement Locknane: I know a little word (words by Geo. Grossmith Jun.); A. Grieg: Love is like sweet briar roses; H. Evan-Jones: Lily of Llanover (words by Cyril Oakes); Henry C.[lay] Work: Marching through Georgia; [John Wall Callcott]: Drink to me only with thine eyes ([words by] Ben Jonson); Claude Melville: Take back thy Gift (words by Edward Oxenford); J.[ohn] L.[iptrot] Hatton: The Lark now leaves his wat'ry Nest (words by sir W.[illiam] Davenant); W.[illiam] H.[erbert] Jude: For King and Country; Fred Whishaw: When all the World is Young (words by Charles Kingsley); Rocked in the Cradle of the Deep; Thomas P.[ayne] Westendore [instead of Westendorf]: Dar's one more ribber for to cross. The Great Jubilee Song (words by James Hosey); James James and Owain Alaw [John Owen]: Land of my Fathers; Gerard F.[rancis] Cobb: Carisbrooke (words by G.[eorgeanne] Hubi Nemcombe; Eliza Cook and John Blockley: Many happy returns of the day; W.[illoughby] H.[unter] Weiss: The Village Blacksmith (words by [Henry Wadsworth] Longfellow); Virginia Gabriel: Cleansing Fires (words by Adelaide Proctor); Henry Bishop: Home Sweet Home ([words by John Howard] Payne); The Campbells are comin'; R.[ichard J.[ohn] S.[amuel] Stevens: Sigh no more, ladies; W. H. Lonsdale: Cupid's Darts; S.[ydney] Nelson: Madoline (Edward J. Gill); Adam Geibel: Wonderland. Fairy Lullaby; Clementine ([words by] Percy Montrose [instead of Montross]); The harp that once thro' Tara's halls; A.[lexander] Hume: Afton Water; Arthur S.[eymour] Sullivan: If doughty deeds my lady please (words by [Robert Cunninghame] Graham of Gartmore); A. Grieg: To Daffodils (from love's litanies) (words by Kenneth Douglas); Claude Melville and W[illia]m Cartwright Newsam: The Angelus; [Friedrich Glück:] The Mill Wheel (“In einem kühlen Grunde”; [words by Joseph von Eichendorff]); Ch.[arles] Gounod: When all was young. Romance from "Faust" (“Si le bonheur à sourer t’invite”); Bonnie Dundee; Claribel [pseudonym of Charlotte Alington Barnard]: Take back the heart ([words by] G. R. Gifford); Julius Benedict: Eily Mavourneen; Julius Benedict: I'm Alone; Arthur [Seymour] Sullivan: A Hymn of the Home-land (words by H.[ugh] R.[eginald] Haweis); Caller Herrin'; C.[harles] Gounod: Serenade ([words by Victor Hugo]); John Peel; Claribel: Come Back to Erin; The wearing of the Green; Claribel: I cannot sing the Old Songs; John Hullah: The Storm. Descriptive song (words by Adelaide Procter); The Blue Bells of Scotland; Julius Benedict: By the Sad Sea Waves ([words by] Alfred Bunn); Henry Russell: A life on the ocean wave (words by E.[pes] Sargent); Mary of Argyle; S.[tephen] C.[ollins] Foster: My Old Kentucky Home; The Keel Row; John Brown's Body. March Song of the American Civil War; W.[illiam] H.[erbert] Jude: On the deep blue sea (words by Clifton Bingham); Alfred Redhead: The North Wind doth blow; Poor Old Joe; Brinley Richards: God bless the Prince of Wales; Auld Lang Syne (words by Robert Burns); Claribel: You and I; Claribel: Milly's Faith; Henry Lamb [pseudonym of George L. Spaulding]: The Volunteer Organist ([words by William B. Gray]); Braham: The Anchor's Weigh'd; John Hoskins: Mollie Malone; J.[ames] Pierpont: Jingle Bells; M.[ichael] W.[illiam] Balfe: Come into the garden Maud ([words by] Alfred Tennyson); Dolores [pseudonym of Ellen Dickson]: Wings (words by W.[illiam] Cartwright-Newsam); Joseph Barnby: Sweet and low (arrangement by W.[illiam] H.[erbert] Jude; [words by] Alfred Tennyson); Alfred G.[eorge] Robyn: Answer? Ballad; Claude Melville: Go forth! O my Spirit. Sacred song (words by W.[illiam] Cartwright-Newsam); Victor Girdlestone [pseudonym of Gustav Krenkel]: Life's Secret (words by A.[nna] L.[aetitia] Barbauld); Annie Laurie ([words by Alicia Ann Scott?]); C.[harles] F. Shattuck: A hundred fathoms deep (words by R.[ichard] Cranshaw); Arthur [Seymour] Sullivan: Orpheus with his Lute (words by [William] Shakespeare); Barbara Allen; Francis Böhr: God Bless our England; Fred Whishaw: Music when soft voices die (words by [Percy Bysshe] Shelley); Claribel: Strangers Yet ([words by Richard Monckton Milnes] Houghton); Love's Mirror (arrangement by A. L.); M.[ichael] W.[illiam] Balfe: When other lips; Anton Strelezki: When twilight comes [original title: Dreams] ([words by] Baroness Porteous); W. Jackson: The Dear little Shamrock ([words by] Oherry); John L.[iptrot] Hatton: Good-bye Sweetheart Good-bye ([words by] Folkestone Williams; J.[oseph] Ascher: Alice, where art thou? ([words by Wellington Guernsey]); Edwin Greene: My Home (words by Clifton Bingham); M.[ichael] W.[illiam] Balfe: Killarney ([words by] E.[dmund] Falconer); Comin; thro' the Rye; [Henry] R.[owley] Bishop: Chime again, beautiful Bells; Francis Böhr: Love's Message (words by Maud Bolton); Within a Mile of Edinburgh Toon; Henry R.[obinson] Allen: Maid of Athens ([words by] Lord Byron); Louis Diehl: Jack's Yarn (words by F.[rederick] E.[dward] Weatherly
HUME AND HIS CRITICS: Reid and Kames
No full textThis presentation was in response to Kenneth MacKinnon’s defense of Thomas Reid’s preference for natural virtue against David Hume’s conventionalism in his theory of law. It is argued that because Hume’s legal theory follows easily from his theory of human nature, Reid and Kames—and MacKinnon—need to refute Hume at that level to be successful in their rejection of his conventionalism
A culture that is hard to defend: extralegal factors in federal death penalty cases
No full textEmpirical research has exposed a troubling pattern of capital punishment in the United States, with extralegal factors such as race, class, and gender strongly correlated with the probability of a death sentence. Capital sentencing also shows significant geographic disparities, although existing research tends to be more descriptive than explanatory. This study offers an alternative conception of local legal culture to explain place-based variation in the outcomes of federal capital trials, accounting for the level of attorney time and expert resources granted by the federal courts to defend against a death sentence. Using frequentist and Bayesian methods—supplemented with expert interviews—we empirically assess the processes determining the total allocation of defense resources in federal death penalty trials at the peak of the federal death penalty—between 1998 and 2004. Our findings strongly connect extralegal factors to the lowest levels of defense resources, which in turn correlate with a higher risk of a death sentence. Far from being idiosyncratic discrepancies, these are systemic and systematic extralegal factors that stand between a defendant and his opportunity to defend against a death sentence. Ultimately, we argue for a reconceptualization of extralegal influences and the relationship between local legal culture and capital case outcomes.Peer reviewe
Kenneth B. Clark (ca. 1989)
No full textThis photograph shows Kenneth B. Clark, an honorary degree recipient at the 1989 Springfield College Commencement Ceremony. He is pictured sitting in a chair with his elbow on the arm of the chair and his chin resting on his hand. The photo is taken by famed photographer, Raimondo Borea. He is wearing a suit. The college gave him the honorary degree because he demonstrated a lifetime commitment to the Humanics philosophy followed by Springfield College.Kenneth B. Clark earned his Ph.D. in social psychology from Columbia University and went on to become a Distinguished Professor of Psychology Emeritus of the City College of the City University of New York. He also is the author of several books and articles, including "Prejudice and Your Child," "Pathos of Power," and "Dark Ghetto." He qualified to present his research on the effects of segregation on children to the United States Supreme Court during the 1954 decision of Brown vs. Board of Education. He and his wife were also co-founders of the Northside Center for Child Development and he also is noted for his work with Harlem Youth Opportunities Unlimited. His previous awards include: 1961 recipient of the Springain Medal, 1985 recipient of the Franklin Delano Roosevelt Four Freedom Award, and 1986 recipient of the Medal of Liberty Award. He served for twenty years as a member of the Board of Regents of the State of New York, and is President of Kenneth B. Clark & Associates, Inc., a firm that provides consultation to educational institutions, corporations and government agencies.Copyright is not owned by Springfield College. Photograph was a print supplied for purposes of promotion for Kenneth B. Clarke's honorary degree. Photograph was taken by Raimondo Borea. On back the photograph is stamped copyright: Raimondo Borea ASMP /245 West 104th Street / New York, N.Y 10025. Please see rights information for use directions.
Generalized measures for physical properties of nonperiodic chains
No full textPT: J; CR: AVISHAI Y, 1990, PHYS REV B, V41, P5492 BORN M, 1965, PRINCIPLES OPTICS BURROWS BL, 1991, J PHYS A-MATH GEN, V24, P3979 DAVISON SG, 1992, BASIC THEORY SURFACE GUMBS G, 1989, J PHYS A-MATH GEN, V22, P951 KIANG D, 1990, AM J PHYS, V58, P1200 KOHMOTO M, 1987, PHYS REV LETT, V58, P2436 KOLAR M, 1991, PHYS REV B, V43, P1034 PATTNAIK RK, 1992, J PHYS A-MATH GEN, V25, P577 THAKUR PK, 1992, J PHYS-CONDENS MAT, V4, P6095; NR: 10; TC: 5; J9: PHYS REV B; PG: 7; GA: QL717Source type: Electronic(1
Transmission through two-dimensional tight-binding lattices
No full textA methodology of transmission through two-dimensional tight-binding lattices is presented. The theory is formulated in terms of matrix algebra and the relationships between the matrices are examined in detail. The features specific to tight-binding systems are contrasted to those for more general transmission problems. Illustrative examples are given to indicate the wide applicability of the methodology.PT: J; CR: BARUT AO, 1992, PHYS REV LETT, V68, P3571 FARCHIONI R, 1996, PHYS REV B, V53, P4294 HUANG DH, 1992, SOLID STATE COMMUN, V84, P1061 IMRY Y, 1986, EUROPHYS LETT, V1, P249 KOLAR M, 1989, J PHYS-CONDENS MAT, V1, P823 PICHARD JL, 1994, THESIS U PARIS ORSAY SCHWABE H, 1997, PHYS REV B, V56, P8026 TSUNETSUGU H, 1988, PHYS REV B, V38, P10109 TSUNETSUGU H, 1990, J PHYS SOC JPN, V59, P3057 TSUNETSUGU H, 1991, PHYS REV B, V43, P8892 UEDA K, 1987, PHYS REV LETT, V58, P1272; NR: 11; TC: 1; J9: PHYS REV B; PG: 6; GA: 372FWSource type: Electronic(1
Many-electron theory of resonant charge transfer: Role of surface states in He and He+ scattering off Si(100)
No full textA many-electron theory of resonant charge transfer, originally formulated for the scattering of an atom with an empty valence orbital from a surface, is extended to treat the case where the valence orbital is initially occupied by one or two electrons. The scattering of He and He+ from the Si(001) surface is investigated. The interaction is assumed to be with the narrow band of surface states, and not the much wider bulk band. As a result, considerable oscillations are found in the ionization and/or neutralization probabilities as a function of the incident energy.PT: J; CR: AMOS AT, 1989, ADV CHEM PHYS, V76, P335 AMOS AT, 1989, SOLID STATE COMMUN, V71, P449 BLOSS W, 1978, SURF SCI, V72, P277 BRAKO R, 1981, SURF SCI, V108, P253 BURROWS BL, 1984, Q APPL MATH, V42, P73 BURROWS BL, 1990, J PHYS A-MATH GEN, V23, P1101 BURROWS BL, 1991, SURF SCI, V253, P365 CHADI DJ, 1975, PHYS STATUS SOLIDI B, V68, P405 HAGSTRUM HD, 1954, PHYS REV, V96, P336 HAGSTRUM HD, 1961, PHYS REV, V122, P83 HERMAN F, 1963, ATOMIC STRUCTURE CAL IHM J, 1980, PHYS REV B, V21, P4592 MUDA Y, 1980, SURF SCI, V97, P283 MUDA Y, 1988, NUCL INSTRUM METH B, V33, P388 MUDA Y, 1988, PHYS REV B, V37, P7048 PAULING L, 1935, INTRO QUANTUM MECHAN ROBERTS N, 1990, SURF SCI, V236, P112 SOUDA R, 1985, SURF SCI, V150, L59 SOUDA R, 1986, NUCL INSTRUM METH B, V15, P114 SOUDA R, 1986, NUCL INSTRUM METH B, V15, P138 SOUDA R, 1986, SURF SCI, V176, P657 SULSTON KW, 1988, PHYS REV B, V37, P9121 SULSTON KW, 1988, SURF SCI, V197, P555 SULSTON KW, 1989, SURF SCI, V244, P543 WEAKLIEM PC, 1990, SURF SCI, V232, L219 WEISENDANGER R, 1990, SURF SCI, V232, P1; NR: 26; TC: 4; J9: PHYS REV B; PG: 11; GA: HZ245Source type: Electronic(1
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