10,685 research outputs found
Service-oriented models for audiovisual content storage
No full textWhat are the important topics to understand if involved with storage services to hold digital audiovisual content? This report takes a look at how content is created and moves into and out of storage; the storage service value networks and architectures found now and expected in the future; what sort of data transfer is expected to and from an audiovisual archive; what transfer protocols to use; and a summary of security and interface issues
Dr. Stephen Eskilson
No full textStephen Eskilson received his PhD from Brown University in 1995. He is the author of Graphic Design A New History (Yale UP, 3rd ed. 2019) and The Age of Glass (Bloomsbury, 2018). He is an avid sailor and pick-up basketball player.
Featured Bookhttps://thekeep.eiu.edu/authors_at_eiu_bios/1005/thumbnail.jp
Muriel Spark as auto-biographer in <i>Curriculum</i> <i>Vitae</i>
No full textExamining Muriel Spark's main aims as an auto-biographer in her work Curriculum Vitae brings important resources in the exploration of the genre of autobiographical writing. This with the theoretical engagement, allows consideration of the critical issues surrounding the roles of author and reader in the construction of the literary self. Spark demands the reader participate in the constructon of textual meaning; overturning the conventions of autobiography, satirising its claims to omniscience and highlighting the impossibility of an authentic voice with regard to the self
Letter from Stephen T. Mather to Carl Hayden
No full textLetter from Stephen T. Mather to Carl T. Hayden advocating for a reduction in automobile fees for the South Rim entrance
Imaging genetic risk and episodic memory in psychosis
No full textA key feature of many psychiatric disorders, including schizophrenia and bipolar disorder,
are pervasive deficits in several domains of cognition. Episodic memory is one of the most
consistently observed cognitive deficits exhibited by patients with schizophrenia, and can
be a predictor of overall functional outcome. Several neuroimaging studies have assessed
episodic memory in psychosis, however the neural mechanisms underlying this deficit
remain somewhat unclear. Studying the impact of rare genetic variants of large effect can
offer a powerful method to further our understanding of the pathophysiology of psychiatric
disorders. One such gene, DISC1 (Disrupted in Schizophrenia 1) is a putative susceptibility
gene for a spectrum of major psychiatric disorders such as schizophrenia, bipolar disorder
and major depression. DISC1 was originally identified in a large Scottish pedigree, in
which it is disrupted by a balanced translocation between chromosomes 1 and 11, and this
translocation confers a dramatically increased risk of major psychiatric disorder. However,
the impact of this translocation on brain imaging measures is largely unknown. The rarity
of this variation results in small group numbers for analysis, however rare variants are likely
to have large neural effects. This thesis offers a unique investigation into the effects of the
t(1;11) translocation, by examining fMRI of members of the original Scottish pedigree.
Four groups of participants; 19 family members (8 with the translocation, 11 without), 30
patients with schizophrenia, 11 patients with bipolar disorder and 40 healthy controls
underwent a functional MRI episodic memory encoding and recognition paradigm. Data
processing and statistical analyses were performed using the standard approach in SPM8.
The primary aim of this work was to investigate functional activation during episodic memory in individuals with and without the translocation, to examine the impact of the
t(1;11) translocation. Analyses were also performed to examine differences between
controls and patients with schizophrenia and bipolar disorder, to compare the effects of the
translocation to the effects of a having a psychotic illness.
During encoding of neutral scenes, translocation carriers showed greater activation of the
left posterior cingulate, right fusiform gyrus and right superior frontal gyrus compared to
non-carriers. During recognition, carriers showed greater activation in the right fusiform
gyrus, left posterior cerebellum, right superior temporal gyrus, left anterior cingulate, right
ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC).
For both contrasts, no regions were found to be more active in family members without the
translocation when compared to carriers. There were no significant differences between the
groups in terms of their performance or reaction time on encoding and recognition
conditions.
Compared to healthy controls, patients with schizophrenia demonstrated increased
activation during encoding in the inferior parietal lobe bilaterally, and decreased activation
during recognition in a region encompassing the caudate nucleus and anterior cingulate
cortex. Patients with bipolar disorder showed no difference in activation compared to
controls during encoding, and increased activation during recognition in a region
encompassing the caudate and anterior cingulate, extending to the inferior frontal lobe and
insula. There was also a significant difference between patients with schizophrenia and
bipolar disorder during recognition, with patients with bipolar disorder again showing
increased activation in the caudate extending to the anterior cingulate cortex. These findings support previous research suggesting overactivation of fronto-limbic and striatal
structures including the anterior cingulate and caudate in bipolar disorder, with a relative
underactivation in schizophrenia.
This thesis presents the first evidence of functional alterations during episodic memory in
association with the translocation, primarily in fronto-temporal regions. Brain regions that
were over activated in translocation carriers have been shown to be involved in memory
encoding and recognition, and are known to be affected in patients with major psychiatric
disorders and unaffected relatives. Family members with the translocation demonstrated a
more similar pattern of activation during recognition to patients with bipolar disorder
compared to schizophrenia, perhaps due to the fact that most diagnoses in the carriers were
of an affective disorder rather than a schizophrenia-related psychosis. Based on these
findings it can be argued that the translocation has an influence on brain activations in areas
associated with episodic memory processes. These findings begin to provide a better
understanding of the neural effects of the t(1;11) translocation, and highlight the
significance of rare but biologically informative genetic variants in understanding
psychosis
I, Stephen
No full textI, Stephen is a memoir of the author’s time at basic training for the United States Navy. The primary theme explored through this piece is death as a metaphor for change, with smaller themes of relationships, perception versus reality, freedom versus security, and courage. The journey begins with the author’s first experience with near-death as an infant, then moving into his time in basic training which depicts the struggles with daily routines, interactions with officers, and physical ailments, ultimately leading to the author’s departure and eventual attendance at Concordia University – Portland. Through the creative process of this memoir and research into other writers, the author undergoes an evolution where the old version of the author dies and begins the process of rebuilding into a stronger individual, ready to face new challenges ahead
Letter from Carl Hayden to Stephen T. Mather, U.S. National Park Service
No full textLetter from Carl Hayden to Stephen Mather regarding Coconino County's willingness to dispose of Bright Angel Trail as long as the funds acquired would go to building a road between Old Trails Highway at Maine to the Grand Canyon
Between The Lines, Interview with Stephen Pimpare
No full textInterview with Stephen Pimpare, author of “A People’s History of Poverty in America”, on how 15 percent of the overall U.S. population is poor, including 26 percent of Hispanics, 27 percent of African Americans, 22 percent of children under 18, and 9 percent over age 65
Self-consciousness and the image of self in the poetry of Stephen Spender, 1928 to 1934
No full textThe purpose of this thesis is twofold. First, to demonstrate the value and significance of Spender's early poetry in terms of its vision and technique. Through a series of close readings the thesis traces the ways in which Spender's early poetry not only shows itself to be self-conscious but also manipulates images of self. Presenting images of self, Spender achieves a balance between engagement with and distance from the self, and the reader shares in the process of poetic self-awareness. Secondly, to demonstrate the broader value of the poetry. Spender's poetry presents a distinctive exploration of the possibilities of self in relation to the external world. The resolution of Spender’s questioning and selection of both personal and public values, rooted in his contemporary situation and private circumstances, in his poetry takes the form less of historical document than of human record. The period on which I focus, 1928 to 1934, represents Spender’s first, and arguably most significant, poetic phase. The thesis is specifically concerned with four texts: Nine Experiments. Spender's contributions to Oxford Poetry (1929 and 1930), Twenty Poems and Poems (1933 and 1934). Nine Experiments marks the beginning of a particular approach and lyric style which finds its culmination in Poems (1933 and 1934). The earliest poetry is interesting largely insofar as it looks forward to later themes and techniques. In Nine Experiments and Oxford Poetry (1929 and 1930) we see Spender's often successful struggle to achieve effective forms in which to explore issues of self and value. Twenty Poems and Poems (1933 and 1934) concentrate on themes of love and friendship and the pressure on the poet of the contemporary political scene. The poetry does not reconcile the demands of the external, public world with his inner desires and aspirations, but presents a series of fascinatingly unresolved tensions. The thesis explores the way these poems strive for certainty. This striving stems from the tension between Spender's desire to politicize poetry and his tendency to the lyrical, personal statement
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