393 research outputs found
The Theatre of One Eda
No full textThis work concerns with The theatre of One Eda, it talks about the history of this one-woman show, about the creation of performances and about each individual puppet performance for children. Because the tradition of the puppet theatre in the Czech Republic is very strong, the author of this work is trying to answer the question what exactly is the puppet theatre. She also concentrates on a very brief summary of the history of the puppet theatre across the Czech Republic. The first part contains the characteristic of fairy tale, its function - that all is examined with consideration of the children?s viewer. In the second part the author writes about the history of The theatre of one Eda, about the creation of performances. Reactions of different audience are being compared and hold forth in this part. In conclusion there are compared commonly known facts introduced in the first part of this work with information gained by an actress of The theatre of one Eda
Eda : szkice o wyobraźni i poezji
Full text linkThe dissertation, which consists of five chapters, is a poetic record of
Eda Ostrowska’s experiences, incorporated into the critical, as well as the
historical and literary discourse. Titles of the chapters: The Outsider, The
early works, The psychiatric hospital, The body, The son, indicate significant,
themes which strike the reader upon his or her first reading of the books
by the author of Letycja u miecznika.
The first of the texts constitutes a sui generis introduction. It presents
Eda Ostrowska as a detached author, one who is beyond her reality. The poet
seeks refuge in ‘narcotic’ spheres because she is unable to establish an understanding
between herself and the world. In her poems she preservers the
hallucinations that she experiences after the intake of various substances.
From her works emerges a vagabond lyrical I, existing at the edge, dicing
with death. Such an image of the lyrical protagonist characterises above
all the early works of Ostrowska. Therefore it seems that a continuation
of the first text is the discussion featured in the second part of the book.
However, the inspiration for this book is drawn from the diary, which was
published for the second time by the poet in 2013. Many fragments of the
texts, which were contained in the 1983 edition, are missing from the aforementioned
edition. The reading of the notes by a 20-year-old woman, as well
as of some of the works from the Małmazja volume of poetry, produces a
sense of graphomania, but one that is construed as the furor poëticus mentioned
before – an uncontrollable cacoethes scribendi, which constitutes for
Eda certain self-therapy, a means of survival, of overcoming a hostile space
which she inhabits. The third part also discusses the diary. It describes the
psychiatric hospital as a space which is chosen by Eda. In order to analyse
this problem, the author of the present book employs hospital as a different
space, referring to it first as a heterotopy of crisis, and then as a perversion.
The chapter entitled presents the poetry of the author of Śmiech i łaska as
sensualistic, sensual poetry written by a person who is entangled in carnality. In Ostrowska’s works the body is tormented and worn out by the male,
God and the surrounding reality. The son is the title of the final discussion
which is contained in the book. It engages the theme of motherhood as one
of the most painful od Ostrowska’s experiences, which is also brought to
light in the last volumes of poetry by the author of Wierszownik
EDA Gene Mutations Underlie Non-syndromic Oligodontia
Full text linkRecent studies have detected mutations in the EDA gene, previously identified as causing X-linked hypohidrotic ectodermal dysplasia (XLHED), in two families with X-linked non-syndromic hypodontia. Notably, all affected males in both families exhibited isolated oligodontia, while almost all female carriers showed a milder or normal phenotype. We hypothesized that the EDA gene could be responsible for sporadic non-syndromic oligodontia in affected males. In this study, we examined 15 unrelated males with non-syndromic oligodontia. Three novel EDA mutations (p.Ala259Glu, p. Arg289Cys, and p.Arg334His) were identified in four individuals (27%). A genetic defect in the EDA gene could result in non-syndromic oligodontia in affected males.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000263913000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Dentistry, Oral Surgery & MedicineSCI(E)PubMed34ARTICLE2126-1318
Eda tools and methodologies for reliable nanoelectronic systems
No full textIn recent years, advances in technology have enabled the employment of automated systems to control driving tasks. The idea of electronic devices having complete control over a vehicle promises to change the concept of mobility soon. However, allowing computers to control all the tasks in a vehicle demands sophisticated systems and significant safety concerns. Furthermore, the increasing complexity in such applications is causing a shift in the traditional design flow. For example, the development of semiconductors implementing safety-critical functionalitiesmust incorporate mechanisms to reduce the risk of failures avoiding life-threatening situations. This dissertation addresses the role of the EDA industry in supporting the safety aspects of automotive electronic systems. We propose methodologies to deploy the traditional EDA technologies into functional safety verification, improving compliance to Automotive Safety Standards, like ISO 26262, and ensuring automotive devices’ safety integrity levels. For such, we must comprehend how the guidelines of ISO 26262 establish a comprehensive safety lifecycle that supports the analysis of Systematic Failures and RandomHardware Failures. Afterward,we investigate the many possibilities to advance the state-of-the-art by deploying EDA technologies in compliancewith safety requirements. As a result,we identify research possibilities at different safety lifecycle stages. Furthermore, we propose methodologies to support such development phases, enabling compliance with ISO 26262…Computer Engineerin
EFL classroom code-switching
No full textWith emphasis on teacher and learner code-switching patterns, this book is one of the first studies to comprehensively address these issues in English as a Foreign Language (EFL) classrooms. The author examines teacher and learner code-switching through quantitative analysis, discourse analysis, conversation analysis, and mixed methods used in the study of code-switching. She addresses current debates on the amount of first language (L1) use, the functions of L1 use, the functions of teacher only code-switching patterns and the functions of teacher and learners shared code-switching patterns in foreign language classrooms. The book explores the implications of EFL classroom code-switching and how this can feed into better understanding of foreign language learning and teaching, language teacher development and new research directions in TESOL and applied linguistics. The principles and discussions of EFL classrooms are easily generalised to other language classrooms. This book will be of interest to researchers in the fields of second language acquisition, applied linguistics, and ELT, as well as researchers in the fields of sociology, education, and ethnomethodology. © The Editor(s) and The Author(s) 2016
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The EDA Chokepoint Dilemma? Openness, Oligopolies, and China's Ecosystem
Full text linkOne of the fiercest domains of U.S.-China technology rivalry centers around semiconductors, which enable advances in a range of strategic and essential sectors—from communications and computing, to healthcare, military systems, and transportation. For policymakers interested in stymying Chinese advances in semiconductors, the perfect chokepoint to exploit through export restrictions is a product that plays an indispensable role in the broader ecosystem and is controlled by very few companies with high market-entry barriers. This paper reviews experience with one such product: electronic design automation (EDA) tools. The author argues that the U.S. and allied governments can use EDA as a chokepoint to curb China’s chip design capabilities in the medium term, but that they should also strengthen incentives for the development and adoption of open-source EDA tools by the broader industry. Supporting the development of open-source EDA tools does not diminish their market dominance at the cutting-edge but “democratizes” chip design at the trailing-edge and mature nodes—of high relevance for industrial, automotive, and health applications
Optimising Functional Safety EDA for Accurate Fault Coverage Estimation
No full textThe automotive industry is experiencing a significant shift towards advanced electronic and software integration, driven by the increasing demand for self-driving and autonomous vehicles. With electronics now making up a major portion of vehicle costs, ensuring their reliable operation is critical. However, as the complexity of automotive systems increases, so do the risks associated with malfunctions, requiring a critical need for robust safety measures. Functional Safety (FuSa), as defined by ISO 26262, provides a framework for addressing these concerns at different stages of the safety lifecycle. The primary aim of FuSa is to develop Safety Mechanisms (SM) to detect faults and recover from them. The efficiency of these SMs is indicated by Diagnostic Coverage (DC), which represents the percentage of detected faults. In this context, there are several challenges in verifying the functional safety of automotive chips, especially with RTL designs. For example, identification of safe faults is one of the initial steps in FuSa verification. Discrepancies are observed in their classification when utilising different techniques such as Automatic Test Pattern Generation (ATPG), formal methods and fault injection simulation. This raises questions about the accuracy of overall results obtained from these tools as well. Varying outcomes from fault simulation EDA tools in classifying faults may result in different Automotive Safety Integrity Levels (ASIL) assigned to the component being assessed. This discrepancy would misrepresent the component's ability to reduce associated risks, highlighting the importance of conducting a detailed analysis and comparison of the tools.The thesis provides a comprehensive evaluation of EDA tools utilized for Functional Safety Verification, focusing on RTL designs. Scripts are developed to automate fault simulation flows of two prominent FuSa EDA tools, XFS by Cadence and VC Z01X by Synopsys, and derive automatic comparisons. By comparing these tools, their strengths and limitations are analyzed. XFS exhibits limitations in fault propagation on input and output ports, resulting in the omission of certain fault scenarios. VC Z01X showcases faster fault simulation capabilities along with an extensive feature set for fault simulation, but lacks support for transient fault injection on a section of the fault subspace. By applying the automated tool flows on a FIFO design enabled with ECC, the DC obtained from XFS and VC Z01X are 68.96% and 80.47% respectively, showcasing a major difference. These findings highlight the importance of a holistic verification methodology that accurately estimates diagnostic coverage.A novel verification methodology is proposed, which combines the strengths of XFS and VC Z01X to optimize the efficiency and accuracy of fault simulation. Leveraging VC Z01X's concurrent engine for parallel fault injection and XFS's capabilities to cover the unexplored fault space, this integrated approach provides comprehensive fault coverage. The flow also provides users the capability to update fault classification results based on manual analysis or designer inputs, thereby changing the DC as well. The verification methodology is applied to the AutoSoC benchmark suite, an automotive System-on-Chip with configurable SMs. Based on the results, additional SMs are implemented in the AutoSoC design - duplication of pipeline stages with temporal redundancy and ECC on internal memories. This leads to an estimated area increase of 1.4x as compared to the baseline design, but also results in the qualification of an ASIL C level component with a DC of 97.79%. The baseline verification flow included in the benchmark suite provides a DC of 98.36%, which is an over estimation of the actual coverage. The proposed methodology provides a more accurate coverage by taking into account the maximum possible fault space and considering transient faults as well. While there remains room for further improvement in verification methodologies, this framework effectively addresses the fault space required for FuSa verification and provides an accurate estimation of Diagnostic Coverage.Electrical Engineering | Embedded System
A novel frameshift mutation in the EDA gene in an Iranian patient affected by X-linked hypohidrotic ectodermal dysplasia
No full textPurpose: Ectodermal dysplasias are characterized by developmental abnormalities in ectodermal structures. Hypohidrotic ectodermal dysplasias (HED) are the most common subtype. They are most commonly inherited via X-linked recessive routes. We report on a novel ectodysplasin-A (EDA) mutation that is expected to be involved in pathogenesis of HED. Methods: Hypohidrotic ectodermal dysplasia genes, including EDA, EDAR and EDARADD, were analyzed using next-generation sequencing (NGS). The detected mutation on the EDA gene was confirmed in the patient and his mother using Sanger sequencing. Results: The patient presented with adontia, absence of gum development, hyperthermia and hypohidrosis. Our genetic analysis of the patient revealed a novel frameshift hemizygous mutation (c.898-924 + 8del35ins4CTTA) on the EDA gene. The patient's mother showed a mild HED phenotype. Direct sequencing of the EDA gene in the region where her son had the mutation showed the same mutation in a heterozygous state. Conclusion: We identified a novel frameshift mutation in the EDA gene in an Iranian patient affected by X-linked HED. The difference between our patient's symptoms and those recorded for some previous subjects may be due to the differences in the mutations involved. © 2019 The Author(s)
Author response
No full textArmor plate changes in sticklebacks are a classic example of repeated adaptive evolution. Previous studies identified ectodysplasin (EDA) gene as the major locus controlling recurrent plate loss in freshwater fish, though the causative DNA alterations were not known. Here we show that freshwater EDA alleles have cis-acting regulatory changes that reduce expression in developing plates and spines. An identical T → G base pair change is found in EDA enhancers of divergent low-plated fish. Recreation of the T → G change in a marine enhancer strongly reduces expression in posterior armor plates. Bead implantation and cell culture experiments show that Wnt signaling strongly activates the marine EDA enhancer, and the freshwater T → G change reduces Wnt responsiveness. Thus parallel evolution of low-plated sticklebacks has occurred through a shared DNA regulatory change, which reduces the sensitivity of an EDA enhancer to Wnt signaling, and alters expression in developing armor plates while preserving expression in other tissues
Involvement of and interaction between WNT10A and EDA mutations in tooth agenesis cases in the Chinese population.
No full textBACKGROUND: Dental agenesis is the most common, often heritable, developmental anomaly in humans. Although WNT10A gene mutations are known to cause rare syndromes associated with tooth agenesis, including onycho-odontodermal dysplasia (OODD), Schöpf-Schulz-Passarge syndrome (SSPS), hypohidrotic ectodermal dysplasia (HED), and more than half of the cases of isolated oligodontia recently, the genotype-phenotype correlations and the mode of inheritance of WNT10A mutations remain unclear. The phenotypic expression with WNT10A mutations shows a high degree of variability, suggesting that other genes might function with WNT10A in regulating ectodermal organ development. Moreover, the involvement of mutations in other genes, such as EDA, which is also associated with HED and isolated tooth agenesis, is not clear. Therefore, we hypothesized that EDA mutations interact with WNT10A mutations to play a role in tooth agenesis. Additionally, EDA, EDAR, and EDARADD encode signaling molecules in the Eda/Edar/NF-κB signaling pathways, we also checked EDAR and EDARADD in this study. METHODS: WNT10A, EDA, EDAR and EDARADD were sequenced in 88 patients with isolated oligodontia and 26 patients with syndromic tooth agenesis. The structure of two mutated WNT10A and two mutated EDA proteins was analyzed. RESULTS: Digenic mutations of both WNT10A and EDA were identified in 2 of 88 (2.27%) isolated oligodontia cases and 4 of 26 (15.38%) syndromic tooth agenesis cases. No mutation in EDAR or EDARADD gene was found. CONCLUSIONS: WNT10A and EDA digenic mutations could result in oligodontia and syndromic tooth agenesis in the Chinese population. Moreover, our results will greatly expand the genotypic spectrum of tooth agenesis
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