675 research outputs found
Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism
Get PDFCornelia de Lange syndrome (CdLS) is a multisystem disorder with distinctive facial appearance, intellectual disability and growth failure as prominent features. Most individuals with typical CdLS have de novo heterozygous loss-of-function mutations in NIPBL with mosaic individuals representing a significant proportion. Mutations in other cohesin components, SMC1A, SMC3, HDAC8 and RAD21 cause less typical CdLS
Heal and Adapt : Prototyping productive landscapes in Egypt and Sweden
No full textHeal and Adapt | From Egypt’s dry landscapes to Sweden’s boreal forests, existing and changing climate conditions are raising questions on how to sustain a productive use of land and buildings. By studying and prototyping solutions for adapted resource management, Yosra Malek and Cornelia Redeker claim that cooperation across hemispheres lays the foundation for jointly elaborating transformational knowledge that matters for professional practice as much as for academia.</p
Rosa Cornelia Veal Papers - Accession 1766
Get PDFThe Rosa Cornelia Veal Papers document the professional career, pedagogical philosophy, and personal life of Winthrop College Class of 1926 graduate Rosa Cornelia Veal (1904–1967), an educator whose work spanned elementary classroom instruction, teacher education, and curriculum development during the mid-twentieth century. The collection dates from 1904 to 1978, with the bulk of the materials concentrated between the 1930s and 1940s, corresponding to Veal’s tenure as an elementary school teacher and associate professor of elementary education at Ball State Teachers College.
The collection contains a substantial body of teaching materials that provide insight into classroom practices, instructional methods, and educational priorities of the period. These include lesson manuals, workbooks, visual teaching aids, curriculum guides, and daily classroom records documenting student progress, instructional planning, and classroom activities. Particularly significant are Veal’s classroom record books from 1936–1937 and her extensive use of Compton’s Pictured Teaching Materials, which illustrate the emphasis on visual learning and subject-based instruction in elementary education.Veal’s contributions as an author and curriculum developer are reflected in her published and unpublished writings, including instructional materials created for classroom use and children’s books she helped to author, most notably I Learn to Write. Also included are developmental manuals and religious instructional works prepared under her guidance, demonstrating her interest in holistic child development and literacy education.
Personal materials in the collection include journals and planners spanning two decades, which contain poetry, reflections on daily life, financial notes, reading excerpts, and personal observations. These writings provide a rare and intimate perspective on the professional and personal experiences of a woman educator during the early to mid-twentieth century. Biographical documents—such as probate records, census materials, school report cards, and family histories—further contextualize Veal’s life and career.
The collection also documents Veal’s professional affiliations and community involvement, including her leadership in the Muncie, Indiana branch of the Association for Childhood Education and her membership in the teaching sorority Delta Kappa Gamma. Related materials include correspondence, event ephemera, name cards, and organizational records. Photographs dating from the early twentieth century through the 1940s depict Veal, family members, unidentified individuals, and travel scenes, offering visual context to her personal and professional life.
Additionally, the collection includes a wide array of educational books used by Veal as both a student and educator, as well as miscellaneous ephemera reflecting intellectual, cultural, and everyday interests. Together, the Rosa Cornelia Veal Papers provide a rich resource for research on elementary education, teacher training, women educators, curriculum development, and the lived experience of professional women in education during the twentieth century.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2779/thumbnail.jp
Letter to Cornelia Bradford, Whittier House, from Lida Dodds, secretary to Emerson Miller.
No full textWhittier House scrapbooks document Whittier House programs, events, and anniversary celebrations through newspaper clippings, lecture fliers, newsletters, event programs, and ticket stubs. Newspaper clippings are primarily from the Jersey Journal. There is also Whittier House fundraising materials, including pamphlets, appeal letters, brochures, and postcards. The Whittier House Social Settlement, the first settlement house in New Jersey, was established in Jersey City, N.J. (Hudson County) in 1894. Founded by Cornelia Foster Bradford, who would remain with the organization as headworker until 1926, Whittier House was based on the settlement house, Toynbee Hall, in England. Whittier House provided various recreational and educational programs, along with much needed social services, for the immigrant populations of Jersey City. Many of these successful services were used as models for large-scale social reform movements through the state. In 1935, the Whittier House was taken over by the Boys' Club of Jersey City
Letter to Cornelia Bradford, Whitter House, from G. Fred Ege, Secretary of the Board of Education, Jersey City, expressing the Board's appreciation.
No full textWhittier House scrapbooks document Whittier House programs, events, and anniversary celebrations through newspaper clippings, lecture fliers, newsletters, event programs, and ticket stubs. Newspaper clippings are primarily from the Jersey Journal. There is also Whittier House fundraising materials, including pamphlets, appeal letters, brochures, and postcards. The Whittier House Social Settlement, the first settlement house in New Jersey, was established in Jersey City, N.J. (Hudson County) in 1894. Founded by Cornelia Foster Bradford, who would remain with the organization as headworker until 1926, Whittier House was based on the settlement house, Toynbee Hall, in England. Whittier House provided various recreational and educational programs, along with much needed social services, for the immigrant populations of Jersey City. Many of these successful services were used as models for large-scale social reform movements through the state. In 1935, the Whittier House was taken over by the Boys' Club of Jersey City
Dike relocation Nijmegen-lent: example of adaptive water management?
No full textDike relocation Nijmegen-lent: example of adaptive water management? — TU Delft Research Portal Skip to main navigation Skip to search Skip to main content TU Delft Research Portal Logo Help & FAQ Home Researchers Research Units Research output Activities Datasets Press / Media Prizes Projects Search by expertise, name or affiliation Dike relocation Nijmegen-lent: example of adaptive water management? ME Cuppen, B Stalenberg, C Redeker Policy Analysis Hydraulic Structures and Flood Risk Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review Overview Original language Undefined/Unknown Title of host publication Proceedings of NIG Workconference 2009 Editors Jurian Edelenbos et al. Place of Publication Leiden Publisher NIG Pages 1-22 Number of pages 22 Publication status Published - 2009 Event NIG Workconference …</p
Structure property relationships of model waterborne epoxy varnishes and electrical steel laminates
No full textAuthor DI Cornelia Marchfelder, BScDissertation Johannes Kepler Universität Linz 2025Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Bottlebrush HPMA co-polymers based on a polyphosphazene backbone
No full textAuthor Martina Cornelia Huber BScMasterarbeit Universität Linz 2023Arbeit auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
THE NILE DELTA – WATER INSENSITIVE?
Get PDFABSTRACTThe Nile Delta is considered one of the deltas most vulnerable to climate change worldwide. Apart from the immediate threat of sea level rise it is additionally facing water scarcity, agricultural and ecological degradation in parallel to an unprecedented population increase and the vast urbanization of scarce agricultural land. The urbanization of the Nile Delta, which may be considered an even bigger threat than climate change, is dominated by informal building processes mainly for the lower income sector while the formal sector is planning new cities in the desert. To overcome the pressure of land scarcity in the Nile Valley and Delta, which make up only 4% of the country, the ongoing governmental strategy since the 1970s also for the delta’s fringes has been land reclamation in the desert, for both agricultural, industrial and settlement purposes. Yet, up until today “New Urban Communities” have not been able to attract the designated number of inhabitants as they fail to meet the needs of a large part of the population. Instead they have become market-steered recluses to a growing middle class that longs for a suburban life style and can afford it. Apart from offering a privileged lifestyle, desert developments are investment objects for the private sector. In the formally organized planning processes, sustainable design remains vanguard. As low-rise, high-density and mixed-use neighborhoods, informal developments evolving along canals and transportation nodes in the delta, meet a number of sustainability criteria. While these neighborhoods often lack proper infrastructure and safe accessibility internally, it is their location on scarce agricultural land that proves to be their main deficiency in the light of an increasing geographic vulnerability of the delta. In summary, currently both formal, market-steered developments on reclaimed desert land and informal developments in the Nile Valley and Delta lack ecological awareness. To become more resilient, how can ecological intelligence of people and places be incorporated in this spectrum of formal and informal settlement processes? Water scarcity and quality stand at the top of the list when looking at Egypt today. An overview of current social and spatial conditions in the Nile Delta region and of planning practice in Egypt today depicts a highly complex condition. This paper proposes Water Sensitive Urban Design as a tool for both formal and informal urban developments to negotiate between social and topographical extremes to increase resilience of the Nile Delta and its adjoining desert developments.RESUMENEl delta del Nilo es considerado uno de los deltas más vulnerables al cambio climático en todo el mundo. Además de enfrentarse a la amenaza inmediata del aumento del nivel del mar, debe hacer frente a la escasez de agua, la degradación de la agricultura ecológica y al aumento de población sin precedentes, impulsado por la urbanización de tierras agrícolas. La urbanización del delta del Nilo, que puede ser considerada una amenaza aún más grande que el cambio climático, está dominada por los procesos de construcción informal (principalmente en el valle y el delta, orientado al sector de menores ingresos), y formal (orientada a la planificación de nuevas ciudades en el desierto). Para superar la presión de la escasez de tierras en el valle del Nilo y el delta, que representan solo el 4% del territorio nacional, la estrategia gubernamental desde la década de 1970 ha sido la recuperación de tierras en el desierto tanto para agricultura como para la industria y residencia. Sin embargo, hasta hoy las nuevas comunidades urbanas no han sido capaces de atraer el número deseado de habitantes, ya que no son capaces de satisfacer las necesidades de una gran parte de la población. En la actualidad, ambos desarrollos, sean los formales, dirigidos al mercado en tierra desértica recuperada y los informales en el valle del Nilo y el delta, carecen de conciencia ecológica. Para incrementar la resiliencia ¿cómo puede la inteligencia ecológica de las personas y los lugares incorporarse como una solución en este espectro de procesos formales e informales? La escasez de agua y la calidad se sitúan en la parte superior de la lista cuando se mira en el Egipto de hoy. Una visión general de las actuales condiciones sociales y espaciales en la región del delta del Nilo y de la planificación de la práctica en Egipto hoy en día representa una condición muy compleja. En este trabajo se propone el Water Sensitive Urban Design como herramienta para el desarrollo urbano, tanto de los desarrollos formales como informales, para negociar entre los extremos sociales y topográficos y para aumentar la capacidad de recuperación del delta del Nilo y sus desarrollos desérticos
Rhine Cities - Urban Flood Integration (UFI): German and Dutch Adaptation and Mitigation Strategies
Get PDFWhile agglomerations along the Rhine are confronted with the uncertainties of an increasing flood risk due to climate change, different programs are claiming urban river front sites. Simultaneously, urban development, flood management, as well as navigation and environmental protection are negotiating the border between the river and the urban realm. This produces complex spatial constellations between the river system and the urban realm with a diverse set of interdependencies, where programs have to synergize while adapting to dynamic water levels. Based on an expanding area at risk and the reliance on flood levels to remain within an acceptable spectrum for adaptive measures to be effective, Urban Flood Integration (UFI) involves border negotiations between the river and the urban realm where adaptation and mitigation ideally synergize.
Instead of a scientific approach that reduces complexity in order to reach a verifiable question, a post-normal science approach is chosen as an evaluation and working method applied within this research. The working method relies on literature studies, semi-structured interviews and empirical research through repeated site visits. The general heterogeneity of the case studies regarding their planning structure, status and time scales, data availability and the willingness by the agencies involved to provide usable information shapes the formal research structure.
Part I serves as a narrative for the case study analysis and for the final conclusions and recommendations in Part II. It is made up of three chapters, where Urban Flood Integration is framed historically, theoretically and strategically within the specific geographic context of the navigable Rhine:
Anthropogenic transformations of the Rhine flood plains in the 19th and 20th century have turned formerly wide, often meandering or bifurcating river beds into urbanized embankments along straight, channelled rivers. The perception of the river changed from being dynamic to being controllable. This produced the spatial backdrop for modernist and therefore sectoral developments based on a dialectical relationship between the urban realm and the (river) landscape. Yet, as conversions of former harbours are turning sites outside the flood defence into inner city living quarters, as retention polders are positioned in flood plains with enough damage potential to threaten regional economies, and flood mitigating measures are more viable/effective on site in the middle of the city than in a rural area, site specific negotiations between simultaneous programmatic claims are producing new urban typologies/ecologies that in turn demand and rely on a new methodological approach. Within this research design is considered not only a spatial, but also a strategic tool capable of not only linking different programs, but also different disciplines.
Flood Risk Management along the Rhine today combines river expanding measures and adaptive strategies with the existing defensive system to cope with the risk increase as a consequence of previous interventions and developments and fluctuations in water levels due to climate change. Differences in landscapes and urgencies and differences in planning cultures between the Upper and Lower Rhine and the Delta have also led to different strategic approaches. Within this research the innovative capacity of the adaptive and anticipatory water-based approach in the Netherlands provides lessons to be learned specifically regarding spatial quality as a strategic component of water-related projects.
In Part II, the investigation of two Dutch and two German urbanized water front developments along different river segments of the Rhine according to their synergetic potential, but also regarding the temporal and spatial interdependencies between the river system as a whole, the regional context as well as the actual water front as the project site, aims to examine the following questions: Between adaptive and mitigative strategies, what is the spectrum of spatial constellations between urban development and flood management within the constraints set by navigation and a (partial) restoration of the dynamic river landscape? How are temporal and spatial interdependencies shaping these projects? Relational diagrams show the reciprocations between urban development and river dynamics of each investigated case study and the respective agencies and processes involved. The case study analysis serves as a basis for recommendations for the architectural and programmatic scope of flood-resilient projects dealing with expansive flood management strategies and respectively a strategic design approach addressing multiple scales and programs. Embedded in an exemplary atlas of the respective typology along the different Rhine segments, the four case studies from south to north are:
• Karlsruhe Rappenwört, a steered retention polder along the meandering Upper Rhine
• Mainz Zollhafen, a port conversion with flood adaptive housing along the bifurcating Upper Rhine
• Nijmegen Lent, a bypass and urban extension based on a dike set back along the Waal
• Dordrecht Stadswerven, an urban development outside the dikes in the Delta
In summary, differences in landscape, threat and political structures have produced different planning cultures in Germany and the Netherlands in terms of flood management. Both Dutch and German mitigation measures remain path dependent on the defensive system. Yet, whereas the Dutch approach to flood mitigation is holistic in an extended ecological sense and specifically includes spatial quality, in Germany, planning flood-related issues remains part of a sectoral approach where spatial quality is not initially included, bit remains an additional layer towards the end of the project. Confronted with a strong ecological lobby, the focus is to restore the former alluvial forest in niches. Of the six programs defined in the ICPR Atlas, forestry seems the only one capable of taking on river dynamics and transforming accordingly over time. All other programs (settlements, industries, traffic infrastructure, and to some degree agriculture, specifically when ecological flooding is taken into account) remain reliant on defensive measures, and in case of their failure, infrastructural support and adaptation measures. They are, however, not included in a design strategy that explores potentialities.
In the light of long-term strategies and programs, the Dutch approach offers a more iterative planning practice that is capable of evolving with the experience gained. Dutch experience and corresponding policy adaptation has further shown that a more permissive planning approach to allow additional programs within Room for the River measures can raise local acceptance and thus reduce negative effects. In Germany, water management agencies avoid projects that could become precedence cases and thus enable repetition. This restrictive approach is a hindrance on the way to larger-scale strategies that rely on pilot projects as testing grounds. The Dutch approach seems to aim for incentives and actually provides them, as the trade-off in the Nijmegen case shows. Moving from a restrictive to a responsive planning approach that includes incentives produces a breeding ground and should always be a central component of any strategy. One of the main findings of this research is, specifically in Germany, the limited availability of information, as well as lacking visualization layers of ongoing programs and projects (which may be an additional indication of the lacking involvement of designers in German spatial flood risk management projects). This research contributes to a broader understanding by providing an atlas of selected flood-adaptation and flood-mitigation typologies along the Rhine between Basel and Rotterdam.
Directly adressing the design practice, this research proposes to move from a spatial to a strategic design approach by
involving architects, landscape architects, urban designers from the initial stage to enable their engagement also in the strategic design of a project;
enabling design to become part of a systemic approach that aims for capacity building and therefore includes ecological, economic and cultural conditions through a transdisciplinary approach;
making the invisible layers visible: Visualize systems/expert information to make them accessible and to enable communication between disciplines;
hosting design competitions in cooperation with local stakeholders bringing people and ideas together to trigger emergence;
applying back-casting strategies to move beyond existing conceptions: design may thus becomes “telescopic” and allow a challenge of existing givens, the visualization of concepts again playing a central role.
Two follow-up research projects are proposed:
Development of Design Guidelines for a river segments approach: Evaluation of ongoing or recent mitigation and adaptation projects, but also other river-related developments (e.g. navigation) in an academic research project to define potential emergent capacities between systemic and qualitative elements. In collaboration with the practice, smaller scale pilots as part of existing mitigation programs on a river segment scale could aim to substantiate the findings.
Cost-Benefit-Analysis Spatial Quality: To substantiate the qualitatively developed argument towards Urban Flood Integration (UFI), a cost-benefit analysis of a transdisciplinary layer that is comparable to the measures defined by the Dutch Quality Team for the German Room for the River, which focus today on ecological rejuvenation vs. spatial quality as a secondary aim.
The final outcome of the following multiple case-study investigation and the typological atlas provided is seen to be valuable for a number of different organizations, such as governmental and educational institutions dealing with the geospecific context and spatial development along the Rhine, representatives from the building sector and venture capitalists, as well as people with a personal interest in ecological urbanism in the context of the Rhine
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