20 research outputs found
The scientific basis of rasa (taste) of a substance as a tool to explore its pharmacological behavior
No full textBackground: A rational and well-developed pharmacological basis forms the foundation of therapeutics in Ayurveda. The principles and theories of Ayurveda need to be validated in the scientific context in order to harness the millennia old knowledge. Rasa (taste) of the substance is the foremost tool in Ayurveda to assess and determine the pharmacological properties and actions of the substance. Similarity in rasa is said to signify similar structure and consequently similar pharmacological behavior. Depending on skills developed over the course of long-term clinical experience one, can register the minute variations in rasa of substances and accordingly the possible variations in pharmacological actions. Thus, rasa can be used as a scientific tool in the drug discovery process to limit and focus the target areas.
Aim: To sensitize scientific community to the utility of rasa as a tool in the process of drug discovery.
Materials and Methods: All relevant ancient and contemporary literature was reviewed critically to form a scientific basis of the Ayurvedic concept of rasa as a tool to identify the pharmacological behavior of a substance.
Conclusion: The review finds that rasa (taste) can be used as a guide to identify potential targets in drug discovery
Concept of Ekal Dravya Chikitsa (Single Drug Therapy) in Sushrut Samhita
No full textAyurveda is a holistic health care system which, aims to offer the user an optimum health by alleviating diseases and helps in maintaining, promoting health by advising proper daily and seasonal regimen along with rationalized therapeutics when indicated. A good physician is one who uses minimum substances for desired effect or maximum results. From ancient past, it has been revealed that Ayurveda had a vast knowledge in the field of application of medicinal plants. Medicinal plants have significant importance in human life as it helps in maintaining human health and in improving the quality of life. Also this application in the form of single dravya has also been evidenced in many of Ayurveda texts.
Sushrut Samhita is one of the classical text of Ayurveda, basically a part of Brihatrayee, have been surviving from ancient time and considered to be an important treatise on medicine and surgery. It is one of the two foundational Hindi texts alongside the Charak Samhita, which includes knowledge about medicine as well as surgical training, instruments and procedures. Likewise in charak samita, use of EDC has been also mentioned in Sushrut Samhita for both inervention as well as surgical management of disease. Using Ekal Dravya for curing many disease has been mentioned in past by many of Aacharyas, considering Sushrut Samhita as the first Samhita of Ayurveda to use therapeutic interventions as well as surgical procedure for the management of clinical condition, It has been reviewed to assess the extent of use of EDC.
Using single herb for managing diseased condition has been evidenced at various instances in Sushrut Samhita in conceptual as well as in applied form. This provides an evidenced based proof that EDC was mentioned in our ancient Ayurvea texts which now need to be explored, so as to minimize the load on biodiversity for using minium herbs in a disease where it is sufficed
REVIEW OF HARITAKI (TERMINALIA CHEBULA Retz.) AS AN EKAL DRAVYA CHIKITSA IN BRIHATRAYEE
No full textAyurveda is a traditional system of Indian medicine which aims to promote health and wellness by maintaining equilibrium of all three Dosas of body. Natural medicinal herbs are an important component of this science which aims to protect the body from various ailments and offer an user a variety of health benefits including physical as well as mental health. Haritaki has been placed in high esteem among all medicinal herbs due to its rich property to prevent and cure disease. It is always listed first in Ayurveda as it is called the king of medicines due to its large number of uses having extraordinary therapeutic benefits. Since ancient time, Haritaki has enjoyed a prime place among all medicinal plants. It is being found to be used in many of compound formulations due to its wide spectrum of pharmacological activities. Haritaki is one of three dried fruits that make up the Ayurvedic formula Triphala. It has been used among the large number of population to promote healing from variety of diseases ranging from use as Rasayan to the diseases related to indigestion and many more. Haritaki is being used as a best prescribed remedy for many of the common ailments in day today’s life by large number of physician. It is being used easily in all diseases, either for its health promoting benefit or for its disease alleviating property. Nowadays, using Haritaki as a single Dravya with various Anupaan is a great trend giving optimum results. Ekaldravya concept of using single substances has been mentioned in our ancient Ayurvedic literature. Use of Haritaki as a single drug therapy has been evidenced at various instances in Brihatrayee
Pharmacognostical and Phytochemical Evaluation of a New Anti-Hypertensive Ayurvedic Formulation [NIA/DG/2020/01]
No full textHypertension, also known as high or raised blood pressure, is a multifactorial disease with multiple causes and multiple treatments. The prevalence of hypertension in the urban Indian population was estimated to be 40.8% and in the rural population was 17.9%. Though there are multiple treatment of disease still it is challenge to manage this disease effectively with lower side effects as all available treatments are full of side effects and toxic effects. NIA/DG/2020/01 is a new anti-hypertensive Ayurvedic ghan formulation, containing Arjuna (Terminalia arjuna Roxb.), Ashwagandha (Withania somnifera Linn.), Jatamansi (Nordostachys jatamansi DC.), Shankhpushpi (Convolvulus pluricaulis Chois.), Punarnava (Boerhavia diffusa Linn.), Gojihwa (Onosma Bracteatum Wall.), Guduchi (Tinospora cordifolia Willd.), Mukta Shukti (Margarita) and Praval Pisti (Corrallium Rubrum). All these components are very well known for Hridya, Mootral, Rasayana, Pitta shamak effect and pharmacological actions like cardioprotective, anti-Hypertensive, antioxidant, antimicrobial, antifungal, Antidepressant or anxiolytic, anti-inflammatory, psycho-immunomodulatory effect and acetyl-cholinesterase inhibitory activity etc. Aim and Objective: To perform pharmacognostical, physio-chemical, phytochemical and chromatography evaluation of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01]. Material and Methods: This study involves pharmacognostical, physio-chemical, phytochemical and chromatography evaluation of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01] to ensure its purity, safety and quality. Observations and Results: All the findings of the pharmacognostical, physio-chemical, phytochemical and chromatography evaluation were within the standards of quality. Conclusion: The present sample of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01] was found to be rich in quality and was safe, pure and authentic
General Ailments Related with Agnidushti
No full textAgni is described as an important factor of digestion and metabolism in Ayurveda treatise. Agni is responsible for all the vital functions within body and determines the quantity of food to be consumed. The conversion of ingested food in the form of energy through digestion, absorption and assimilation completely depend upon individual’s Agni i.e., digestive fire. Agni has a significant role in balanced body functioning and keeping the body components in homeostasis. According to Acharya Charak, Dehagni is considered as the cause of life, complexion, strength, lustre, health sustenance, Oja, Teja and it shows the critical importance of Agni in overall health of an individual. Individuals die when their Agni stops working, but when their Agni is Sama (balanced), they are completely well and live a long, happy, and healthy life. When a person’s Agni is vitiated, his entire metabolism is disrupted resulting in bad health and disease. As a result Agni is considered the foundation (Mool) of life. Although the number of Agni in our body is uncountable because it play an important role in metabolism even at cellular or molecular level particularly then also in Ayurvedic texts it mainly considered of 13 types in number. These are one Jatharagni or Koshthagni, five Bhootagni and seven Dhatvagni. Firstly, Jatharagni perform its action in Koshtha (stomach) then Bhootagni and Dhatvagni perform their action. Any kind of disturbance at any level of digestion and metabolism (Aaharpachankriya) leads to certain kind of disruption in normal functioning of Agni. It may be hyper or hypo or fickle state of Agni (Tikshnagni, Mandagni, Vishamagni). These all conditions called as Agnidushti. Agnidushti is a common cause for general health ailments like Ajeerna (indigestion), Amlpitta (acidity), Atisaar (diarrhoea), Arsha, Grahani (IBS or IBD) etc. Consumption of unhealthy food without following the Aaharvidhi described in Ayurvedic texts increasing these health issues day by day. The paper is about to deciphering these ailments in respect with pathogenesis i.e., Samprapti
A Comprehensive Review of Jatamansi (Nardostachys Jatamansi)
No full textJatamansi, that is Nardostachys jatamansi, is a well-known plant used in Ayurveda classics, which is used in “nervous headache, excitement, menopausal symptoms, flatulence, epilepsy and intestinal colic”. A lot of research has also been conducted on this plant exploring its pharmacological utilization. Though there are many review articles available on this plant but no review has comprehensively covered all aspects of Jatamansi. Objectives: This article is thus aim to collect and comprehensively review information available regarding the medicinal use of Jatamansi and identify areas that need further research. Data source: Jatamansi (Nardostachys jatamansi) was reviewed from Samhitas and from more than 55 research articles for medicinal uses and other important aspects. Review methods: This review is in a narrative format and done from literature and publications relevant to Jatamansi that were identified through a systematic search of major computerized medical databases. Result: Jatamansi (Nardostachys jatamansi) is concluded to have indications- Vatavyadhi, Shotha, Shoola, Daha, Varnavikara, Swedadhikya, Apasmara, Apatantraka, Unmada, Manasavikara, Mastishkadaurbalya, Shirahshoola, Agnimandya, Anaha, Udarashoola, Chhardi, Kamala, Hriddrava, Raktabharadhikya, Arsha, Hikka, Kasa, Shwasa, Mootrakrichchhra, Klaibya, Sadyovrana, Bhagna, Garbhashayashotha, Twagvikara, Vatarakta, Sannipatika jwara, Mukharoga, Netraroga, Vishavikara & Bhootabadha. Jatamansi also possesses activities like hepatoprotective, antifungal and antibacterial, cardio protective, hypolipidemic, antidepressant, antioxidant, neuroprotective, antiparkinson, anticonvulsant, antihyperglycemic, nootropic, anticancer and radioprotective. Conclusion: Ayurvedic indications of Nardostachys jatamansi are compared with Article concluded effect and then areas of further research are identified
On the Effect of Clock Frequency on Voltage and Electromagnetic Fault Injection
No full textWe investigate the influence of clock frequency on the success rate of a fault injection attack. In particular, we examine the success rate of voltage and electromagnetic fault attacks for varying clock frequencies. Using three different tests that cover different components of a System-on-Chip, we perform fault injection while its CPU operates at different clock frequencies. Our results show that the attack’s success rate increases with an increase in clock frequency for both voltage and EM fault injection attacks. As the technology advances push the clock frequency further, these results can help assess the impact of fault injection attacks more accurately and develop appropriate countermeasures to address them.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Collected Papers (on various scientific topics), Volume XII
No full textThis twelfth volume of Collected Papers includes 86 papers comprising 976 pages on Neutrosophics Theory and Applications, published between 2013-2021 in the international journal and book series “Neutrosophic Sets and Systems” by the author alone or in collaboration with the following 112 co-authors (alphabetically ordered) from 21 countries: Abdel Nasser H. Zaied, Muhammad Akram, Bobin Albert, S. A. Alblowi, S. Anitha, Guennoun Asmae, Assia Bakali, Ayman M. Manie, Abdul Sami Awan, Azeddine Elhassouny, Erick González-Caballero, D. Dafik, Mithun Datta, Arindam Dey, Mamouni Dhar, Christopher Dyer, Nur Ain Ebas, Mohamed Eisa, Ahmed K. Essa, Faruk Karaaslan, João Alcione Sganderla Figueiredo, Jorge Fernando Goyes García, N. Ramila Gandhi, Sudipta Gayen, Gustavo Alvarez Gómez, Sharon Dinarza Álvarez Gómez, Haitham A. El-Ghareeb, Hamiden Abd El-Wahed Khalifa, Masooma Raza Hashmi, Ibrahim M. Hezam, German Acurio Hidalgo, Le Hoang Son, R. Jahir Hussain, S. Satham Hussain, Ali Hussein Mahmood Al-Obaidi, Hays Hatem Imran, Nabeela Ishfaq, Saeid Jafari, R. Jansi, V. Jeyanthi, M. Jeyaraman, Sripati Jha, Jun Ye, W.B. Vasantha Kandasamy, Abdullah Kargın, J. Kavikumar, Kawther Fawzi Hamza Alhasan, Huda E. Khalid, Neha Andalleb Khalid, Mohsin Khalid, Madad Khan, D. Koley, Valeri Kroumov, Manoranjan Kumar Singh, Pavan Kumar, Prem Kumar Singh, Ranjan Kumar, Malayalan Lathamaheswari, A.N. Mangayarkkarasi, Carlos Rosero Martínez, Marvelio Alfaro Matos, Mai Mohamed, Nivetha Martin, Mohamed Abdel-Basset, Mohamed Talea, K. Mohana, Muhammad Irfan Ahamad, Rana Muhammad Zulqarnain, Muhammad Riaz, Muhammad Saeed, Muhammad Saqlain, Muhammad Shabir, Muhammad Zeeshan, Anjan Mukherjee, Mumtaz Ali, Deivanayagampillai Nagarajan, Iqra Nawaz, Munazza Naz, Roan Thi Ngan, Necati Olgun, Rodolfo González Ortega, P. Pandiammal, I. Pradeepa, R. Princy, Marcos David Oviedo Rodríguez, Jesús Estupiñán Ricardo, A. Rohini, Sabu Sebastian, Abhijit Saha, Mehmet Șahin, Said Broumi, Saima Anis, A.A. Salama, Ganeshsree Selvachandran, Seyed Ahmad Edalatpanah, Sajana Shaik, Soufiane Idbrahim, S. Sowndrarajan, Mohamed Talea, Ruipu Tan, Chalapathi Tekuri, Selçuk Topal, S. P. Tiwari, Vakkas Uluçay, Maikel Leyva Vázquez, Chinnadurai Veerappan, M. Venkatachalam, Luige Vlădăreanu, Ştefan Vlăduţescu, Young Bae Jun, Wadei F. Al-Omeri, Xiao Long Xin.
Clinical Evaluation of a New Ayurvedic Herbo-Mineral Formulation (NIA/DG/2020/01) in Stage -1 Primary Hypertension
No full textHypertension, also known as high or raised blood pressure, is a multifactorial disease with multiple causes and multiple treatments. In India, the prevalence of hypertension was estimated to be 40.8% in urban areas and 17.9% in rural areas. Though there are multiple treatment of disease still it is a challenge to manage this disease effectively with lower side effects as all available treatments are full of side effects and toxic effects. New Ayurvedic herbo-mineral formulation NIA/DG/2020/01 is a new anti-hypertensive Ayurvedic Ghan formulation, containing Arjuna (Terminalia arjuna Roxb.), Ashwagandha (Withania somnifera Linn.), Jatamansi (Nordostachys jatamansi DC.), Shankhpushpi (Convolvulus pluricaulis Chois.), Punarnava (Boerhavia diffusa Linn.), Gojihwa (Onosma Bracteatum Wall.), Guduchi (Tinospora cordifolia Willd.), Mukta Shukti (Margarita) and Praval Pisti (Corrallium Rubrum). Aim and Objective: To assess role of a new Ayurvedic herbo-mineral formulation NIA/DG/2020/01 in Stage-1 primary hypertension. Material and Methods: Initially, the formulations were prepared by the instructions mentioned as per classical text. Then clinical trial was proceeded after ethical clearance and CTRI registration on 60 patients from NIA Arogyashala as per inclusion-exclusion criteria and other said parameters. Observation and Results: Recorded systolic and diastolic blood pressure was tabulated and analysed statistically by SPSS in both the trial groups. Discussion: The result of systolic and diastolic blood pressure changes and percentage of relief was discussed thoroughly. Conclusion: The trial drugs showed highly significant reduction in Blood pressure of stage -01 Hypertension when given at a dose of 1 capsule twice a day before meal for 90 days
