334 research outputs found
Microbial Secondary Metabolites: Recent Developments and Technological Challenges
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
Full text linkThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
Terezine E, bioactive prenylated tryptophan analogue from an endophyte of <i>Centaurea stoebe</i>
Full text linkFungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains. </p
Cataglyphis laylae Cedric A. Collingwood & Donat Agosti & Mostafa R. Sharaf & Antonius van Harten 2011, nov. spec.
No full textCataglyphis laylae Collingwood nov. spec. Plates 96–103 Cataglyphis desertorum Forel, 1894, teste Collingwood, 1985; unavailable name according to Agosti (1990). Specimens examined: Holotype: 1 ☿, United Arab Emirates, al-Ain [24°13'N 55°46'E], iii.1995, leg. C.A. Collingwood (MHNG). Paratypes: 3 ☿, al-Ain zoo, 13.iii.2005, CAC. 1 ☿, Remah, 9.iii.1995, CCA. 3 ☿, Remah, resthouse, 250 m, irrigated sand dune [24°10'37"N 55°18'6"E], 18.iii.1995, leg. D. Agosti. 6 ☿, Remah, resthouse, 250 m, irrigated sand dune, nest with one entrance, [24°10'37"N, 55°18'6"E], 18.iii.1995, leg. D. Agosti. 1 ☿, Sharjah Desert Park, 5–6.x.2004, AvH; 1 ☿, 3.iii.2005, CAC. 1 ☿, al- Za'aba, 100 m, sandy soil with Rhaisa stricta [23°43'20"N, 55°33'49"E], 22.iii.1995, leg. D. Agosti. Description: A large worker from al-Ain was selected as holotype. The measurements are as follows: total length 8.40; head width 3.60; head length 4.20; scape length 3.84; funicular segment I 0.40; funicular segment II 0.23; petiole length 1.10; petiole width 0.72. Colour dark reddish brown. There are no exterior hairs on the scapes or hind tibia. The gaster, petiole and propodeum have dorsal hairs. Remarks: This species thought to correspond with C. desertorum has to be described as a new species. In fact it is one of the commonest Cataglyphis in southern Arabia. The main distinguishing feature compared with other dark Cataglyphis is the slender petiole, which has the anterior face more sloped than in other similar species such as C. niger (André, 1882) and C. savignyi (Dufour, 1862). Biology: Cataglyphus laylae nov. spec. does not appear to occur in open sandy desert and is most abundant in disturbed habitats such as man-developed plantations and open cultivated fields. Distribution: This species was recorded by Collingwood (1985) as C. desertorum from Saudi Arabia and Oman and as Cataglyphis spec. by Collingwood & Agosti (1996). Etymology: The new species is named after a village settlement called “Layla”, just north of Riyadh (Saudi Arabia) in the area where the author (CAC) first encountered it in numbers in an Acacia plantation.Published as part of Cedric A. Collingwood, Donat Agosti, Mostafa R. Sharaf & Antonius van Harten, 2011, Order Hymenoptera, family Formicidae, pp. 1-70 in Arthropod fauna of the UAE 4 on page 54, DOI: 10.5281/zenodo.116858
Natural product diversity of actinobacteria in the Atacama Desert
Full text linkNatural Product diversityPeer reviewe
NMR characterisation of natural products derived from under-explored microorganisms
No full textMicrobial natural products has drawn a great attention from both academia and industry. Obtaining the planar, relative, and possibly the absolute configuration of such novel metabolites requires considerable efforts. In this chapter, the general NMR experiments that were traditionally used, and the recently introduced pulse sequences that provide more precise output in significantly shorter times, and applicable to high throughput screening are discussed. Additionally, various dereplication approaches that allow tracking of new metabolites were highlighted. Lastly, the power of CASE in the structural identification and confirmation of manually-elucidated molecules using selected examples from our research projects was demonstrated
Bioactive natural products from the Red Sea
Full text linkThe marine environment has proven to be a rich source of diverse natural products with relevant activities such as anticancer, anti-inflammatory, antiepileptic, immunomodulatory, antifungal, antiviral, and antiparasitic [...
Cecropin A Improves the Antibacterial Activity of Hen Egg White Lysozyme against Challenging Salmonella enterica Serovars
Full text linkThe prevalence of multidrug-resistant Salmonella enterica among animal- and plant-derived food products threatens global healthcare and economic sectors. Hen egg white lysozyme is widely exploited as a food preservative against Gram-positive pathogens. Nevertheless, its limited penetration of the outer membrane renders it ineffective against Gram-negative bacteria. Herein, we present a safe and effective approach to facilitate HEWL access to peptidoglycan layers using cecropin A. In silico analysis of cecropin A peptide revealed an amphipathic α-helical peptide with potential outer membrane permeabilizing activity through its interaction with both hydrophobic and ionic stabilizing forces. Evaluation of HEWL/cecropin A combination showed a cecropin A dose-dependent bacterial count reduction up to 4.16 and 3.18 ± 0.26 log units against Salmonella enterica ATCC 35664 at the logarithmic and stationary growth phases, respectively. Moreover, the combination displayed antibacterial activity of 2.1 ± 0.31 and ~1 log-unit reductions against Salmonella enterica serovars Kentucky, Typhimurium, and Enteritidis, respectively, whereas Hato and Shangani were found irresponsive. The cytotoxicity assay revealed compatibility of cecropin A with oral epithelial cells. These observations suggest HEWL/cecropin A combination as an effective and safe alternative to lysozyme against Salmonella enterica
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