4,751,686 research outputs found
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
No full textElevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets
Real Exchange Rate in China : A Long-run Perspective
No full textThis paper investigates the RMB exchange rate from a long-run viewpoint. Whether Chinas rapid economic growth brought about real exchange rate appreciation between 1975 and 2002 is empirically examined, based on a supply-side model, the BalassaSemuelson Hypothesis (BSH). The same test is conducted on Japan, Hong Kong, Korea, Malaysia, Singapore, Thailand, the Philippines, Indonesia and India. Our result indicates that the BSH only exists where the industrial structure has been upgraded and the economy has been successfully transformed from an agricultural economy to a manufacturing economy. Interestingly, China, among those where the BSH does not present, appears to be upgrading its industrial and trade structure. We then try to answer the question of why past rapid growth has no significant relationship with the RMB real exchange rate and what factors are underlying the trend of the RMB real exchange rate. We expect an appreciating trend of RMB real exchange rate in the foreseeable future, presuming that Chinas industrial upgrading process continues and the factors pertaining to the BSHs prediction, such as rise of wage rates in both tradables and nontradables, become more significant.RMB real exchange rate, economic growth
Reynolds number dependence of the dimensionless dissipation rate in stationary magnetohydrodynamic turbulence
No full textResults on the Reynolds number dependence of the dimensionless total dissipation rate C_ε are presented, obtained from medium to high resolution direct numerical simulations (DNSs) of mechanically forced stationary homogeneous magnetohydrodynamic (MHD) turbulence in the absence of a mean magnetic field, showing that C_ε -> const with increasing Reynolds number. Furthermore, a model equation for the Reynolds number dependence of the dimensionless dissipation rate is derived from the real-space energy balance equation by asymptotic expansion in terms of Reynolds number of the second- and third-order correlation functions of the Elsässer fields z± = u ± b. At large Reynolds numbers we find that a model of the form C_ε = C_ε,∞ + C/R describes the data well, while at lower Reynolds numbers the model needs to be extended to second order in 1/R in order to obtain a good fit to the data, where R is a generalised Reynolds number with respect to the Elsässer field z-
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Does exchange rate volatility hinder export growth? Additional evidence
No full textThe authors examine the impact of exchange rate volatility on trade, using and ARCH-in-mean model. The advantages of this statistical approach over earlier approaches is that it provides more efficient coefficient estimates and it prevents the problem of spurious regressions. They applied the model to six countries, estimating both bilateral and aggregate exports. The results led to the hypothesis that the impact of exchange rate volatility may be influenced by the invoicing of exports. Also, one can argue that the effect of exchange rate volatility on trade is overstated, for the following reasons: exchange rate volatility does not measure the added riskiness of a firm's portfolio;exchange rates can provide a natural hedge in a firm's portfolio; exchange rates may be negatively correlated with each other or with the firm's other assets; and finally, the use of forward markets can provide a useful short-term hedge.Economic Stabilization,Environmental Economics&Policies,Macroeconomic Management,Fiscal&Monetary Policy,Economic Theory&Research
Single-equation estimation of the equilibrium real exchange rate
No full textEstimating the degree of exchange-rate misalignment remains one of the most challenging empirical problems in an open economy. The basic problem is that the value of the real exchange rate is not observable. Standard theory tells us, however, that the equilibrium real exchange rate is a function of observable macroeconomic variables and that the actual real exchange rate approaches the equilibrium rate over time. A recent strand of the empirical literature exploits these observations to develop a single-equation approach to estimating the equilibrium real exchange rate. Drawing on that earlier work, the authors outline an econometric methodology for estimating both the equilibrium real exchange rate and the degree of exchange-rate misalignment. They illustrate the methodology using annual data from Cote d'Ivoire and Burkina Faso.Fiscal&Monetary Policy,Economic Theory&Research,Environmental Economics&Policies,ICT Policy and Strategies,Scientific Research&Science Parks,Economic Stabilization,Macroeconomic Management,Economic Theory&Research,Environmental Economics&Policies,Achieving Shared Growth
Rate of breakup of small inertial aggregates in homogeneous turbulence
No full textThe hydrodynamic breakup of small inertial aggregates in homogenous and isotropic turbulence is studied through numerical simulations. Small inertial aggregates are subject to shear stress caused by the local velocity gradient and drag stress caused by the relative velocity of the aggregate and the fluid flow. In our simulations, we follow aggregates moving through the flow and record the total stress acting on them. Breakup is assumed to occur when the total stress overcomes a predefined threshold representing the aggregate strength. By determining how long it takes for an aggregate to reach a stress exceeding its strength for the first time, we are able to derive a breakup rate. It is found that with increasing aggregate inertia, the drag stress rapidly becomes the dominant stress resulting in an increase of the breakup rate with increasing the aggregate inertia
- …
