1,747 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
A Systematic Review of the Economic Burden of Diabetes in Eastern Mediterranean Region Countries
No full textMuhammad Subhan Arshad,1,2 Faleh Alqahtani,3 Muhammad Fawad Rasool1 1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 2Department of Pharmacy, Southern Punjab Institute of Health Sciences, Multan, 60000, Pakistan; 3Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Muhammad Fawad Rasool; Faleh Alqahtani, Email [email protected]; [email protected]: Diabetes Mellitus (DM) is a highly prevalent non-communicable disease with high mortality and morbidity, which imposes a significant financial impact on individuals and the healthcare system. The identification of various cost components through cost of illness analysis could be helpful in health-care policymaking. The current systematic review aims to summarize the economic burden of DM in the Eastern Mediterranean Region (EMR) countries. The original studies published in the English language between January 2010 and June 2023 reported the cost of DM was identified by searching four different databases (Google Scholar, PubMed, Science Direct, and Cochrane Central). Two reviewers independently screened the search results and extracted the data according to a predefined format, whereas the third reviewer’s opinion was sought to resolve any discrepancies. The costs of DM reported in the included studies were converted to USD dates reported in the studies. After the systematic search and screening process, only 10 articles from EMR countries met the eligibility criteria to be included in the study. There are substantial variations in the reported costs of DM and the methodologies used in the included studies. The mean annual cost per patient of DM (both direct and indirect cost) ranged from 555.20 USD to 1707.40 USD. The average annual direct cost ranged from 155.8 USD to 5200 USD and indirect cost ranged from 93.65 USD to 864.8 USD per patient. The studies included in the review obtained a median score of 8.65 (6.5 ─ 11.5) on the quality assessment tool based on Alison’s checklist for evaluation of cost of illness studies. There is a significant economic burden associated with DM, which directly affects the patients and healthcare system. Future research should focus on refining cost estimation methodologies, improving the understanding of study findings, and making it easier to compare studies.Keywords: cost of illness, economic cost, healthcare cost, direct cost, indirect cost, diabete
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Challenges and Considerations in Assessing GERD: A Critical Review of a Study in Southern Punjab, Pakistan [Response to Letter]
No full textMuhammad Fawad Rasool,1 Rimsha Sarwar,1 Muhammad Subhan Arshad,1,2 Imran Imran,3 Hamid Saeed,4 Abdul Majeed,1 Muqarrab Akbar,5 Muhammad Omer Chaudhry,6 Anees Ur Rehman,1 Waseem Ashraf,3 Tanveer Ahmad,7 Waleed Badoghaish,8 Faleh Alqahtani9 1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 2Department of Pharmacy, Southern Punjab Institute of Health Sciences, Multan, 60000, Pakistan; 3Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 4University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, 54000, Pakistan; 5Department of Political Science, Bahauddin Zakariya University, Multan, 60800, Pakistan; 6School of Economics, Bahauddin Zakariya University, Multan, 60800, Pakistan; 7Institute for Advanced Biosciences (Iab), CNRS UMR5309, INSERM U1209, Grenoble Alpes University, La Tronche, 38700, France; 8Department of Internal Medicine, College of Medicine, University of Tabuk, Tabuk, 71411, Saudi Arabia; 9Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Muhammad Fawad Rasool; Faleh Alqahtani, Email [email protected]; [email protected]
آثار و احکام عبادی عضو پیوندی در فقه امامیه
No full textBackground and Aim: Nowadays, with regard to progress of medical science, in some cases, people transplant organs due to illness, accidents, etc. Imami jurists have allowed organ transplantation based on some conditions. But this question arises: what is the rule of this new organ-which is an artificial organ or an organ separated from an animal or human-in terms of jurisprudence, and what is the duty of the person who has transplanted while doing religious duties (ablution, Ghosl, prayer and Hajj)? The purpose of this research is analyzing the religious effects and rules of transplanted organs.
Materials and Methods: In order to explain religious duty of a person who has transplanted, this descriptive-analytical research aims to study the rules of organ transplantation by separating the different cases while studying the narrations related to the issue and jurisprudential rules and texts.
Conclusion: In natural organs (both human and animal body parts) if the transplanted organ welds, is a part of the person's body and is pure. Also, about parts without soul-except for the parts of an impure animal-even if the part is not welded, it is pure. But in this case-unlike the previous case-it is not considered a part of the person's body, so there is no need to wash or anoint it while ablution or Ghosl. About the organs with soul, even though they are impure as long as they are not transplanted, but in case of necessity and urgency, there is no problem in praying with them. Also about artificial organs, if the parts of an impure animal are not used in them, they don’t affect the validity of the prayer.زمینه و هدف: امروزه با توجه به پیشرفت علم پزشکی، در مواردی افراد به سبب بیماری، تصادفات و غيره اقدام به پیوند عضو می کنند. فقهای امامیه پیوند عضو را بر اساس شرایطی، مجاز شمرده اند. با این وصف چنان چه یک فرد، عضو جدیدی به بدن خود پیوند بزند، این پرسش مطرح می شود که این عضو جدید ـ که یک عضو مصنوعی یا عضوی جدا شده از حیوان یا انسان است ـ از لحاظ فقهی چه حکمی دارد و وظیفه شخص دارنده چنین عضوی، به هنگام انجام تکالیف شرعی (وضو، غسل، نماز و حج) چیست؟ هدف از انجام این تحقیق آن است که احکام عبادی مربوط به عضو پیوندی، با نگاه تحلیلی، تبیین شود.
مواد و روشها: این پژوهش بر اساس روش توصیفی تحلیلی و در راستای تبیین وظیفه شرعی شخص دارای پیوند عضو، با بررسی روایات مرتبط با مساله و نیز قواعد و متون فقهی، بر آن است تا با تفکیک حالات مختلف پیوند عضو، حکم هر مساله را مورد بررسی قرار دهد.
نتیجهگیری: در اعضای طبیعی (چه اجزای بدن انسان و چه حیوان)، عضو پیوندی در صورت جوش خوردن، از عنوان میته بودن خارج شده و جزو بدن شخص محسوب می شود و پاک است. همچنین در اجزای فاقد روح ـ به جز اجزای حیوان نجس العین ـ حتی در صورت عدم جوش خوردن، عضو، پاک محسوب می شود؛ اما در این حالت ـ برخلاف مورد پیشین ـ عضو پیوندی چون جزو بدن فرد محسوب نمی شود، چنان چه از اعضای وضو یا غسل باشد، نیازی به شستن یا مسح آن نیست. اعضای دارای روح نیز اگرچه تا زمانی که پیوند نخورده، نجس است؛ اما در صورت ضرورت و اضطرار حمل آن در نماز بدون اشکال بوده و خللی به صحت نماز وارد نمی سازد. اعضای مصنوعی نیز اگر در ساخت آنها از اعضای حیوان نجس العین استفاده نشده باشد، وجود آنها در صحت نماز خللی وارد نمی سازد
حکم فقهی سلب حیات از جنینهای آزمایشگاهی
No full textBackground and Aim: A fetus that develops normally is subject to such rules as the sanctity of abortion. The jurists agree that abortion is a crime and depending on how long the sperm has entered the mother's womb and the steps taken, the offender must pay blood money. This study aims to investigate the possibility of spreading natural abortion rulings on embryos in vitro based on jurisprudential sources and documents.
Materials and Methods: The present analytical descriptive study has been written using library data, both real and cyber. Thus, first of all, the reasons that can be cited in Imami jurisprudential sources regarding abortion has been planned and then by analytical method it has been tried to examine the possibility of spreading the rules of natural abortion to the embryos in vitro abortion. In this regard, since the most important document of these rulings are narrations that express the sanctity of abortion, these narrations have been studied and by examining the word embryo in them and also the way or subject of its formation, the possibility of inclusion of narrations in relation to embryos in vitro is measured.
Conclusion: Studies have shown that among the jurists regarding the deprivation of life of embryos produced by abnormal fertilization, two theories of permissibility and impermissibility have been proposed. By the review of the documents of the two theories, it appears that the reasons for deprivation of life impermissibility are more certain and strong. Then there is no difference between an embryo in vitro and a natural embryo in deprivation of life. Destroying the embryos in vitro is not permissible as well as the naturall embryos, unless in special cases that the secondary titles require otherwise.زمینه و هدف: جنینی که به شیوه معمول به وجود میآید، مشمول احکامی نظیر حرمت سقط است. فقیهان اتفاق نظر دارند که سقط جنین جرم محسوب میشود و بسته به مدتی که نطفه (زیگوت) وارد رحم مادر گشته و مراحل طی شده، مجرم باید دیه بپردازد. این پژوهش بر آن است که امکان سرایت احکام مربوط به سقط جنین طبیعی بر جنینی که در لولههای آزمایشگاهی تولیدشده را بر اساس منابع و مستندات فقهی مورد بررسی قرار دهد.
مواد و روشها: مقاله حاضر به روش توصیفی تحلیلی و با استفاده از دادههای کتابخانهای اعم از حقیقی و سایبری، به نگارش درآمده، بدینترتیب که ابتدا کلیه دلایلی که در منابع فقهی امامیه در زمینه سقط جنین قابل استناد بوده، طرح و آنگاه به روش تحلیلی سعی شده تا امکان سرایت احکام سقط جنین طبیعی به سقط جنین آزمایشگاهی مورد بررسی قرار گیرد. در این راستا چون مهمترین مستند احکام مزبور، روایاتی هستند که حرمت سقط جنین را بیان میکنند، این روایات مورد مداقه قرار گرفته و با بررسی واژه جنین در آنها و همچنین طریقیت یا موضوعیتداشتن نحوه شکلگیری آن، امکان شمول روایات نسبت به جنینهای آزمایشگاهی سنجیده میشود.
نتیجهگیری: بررسیهای صورتگرفته بیانگر آن است که میان فقیهان در زمینه سلب حیات جنینهای تولیدشده از راه لقاح غیر طبیعی، دو نظریه جواز و عدم جواز مطرح شده که از نقد و بررسی مستندات دو نظریه چنین برمیآید که دلایل قول به عدم جواز سلب حیات، از اتقان و استحکام بیشتری برخوردار است. بنابراین در حکم سلب حیات فرقی میان جنین آزمایشگاهی و طبیعی وجود ندارد و همانطور که سقط جنینهای تشکیلشده به صورت طبیعی، جایز نیست، انعدام جنینهای آزمایشگاهی نیز دارای همین حکم بوده، مگر آنگه در موارد خاص عناوین ثانوی به نحو دیگری اقتضا نماید
Correction Factor on Dynamic Force in a Marsh Funnel Test for Tunneling
No full textThis paper presents an improvement on a previous model for predicting the Marsh funnel (MF) test that is used in slurry shield tunneling for evaluating the rheological properties of bentonite slurries. The improvement focuses on the prediction of the dynamic part for fluids with small MF times. The velocity profile of the Herschel-Bulkley fluid in a laminar pipe flow condition is first investigated and a correction factor is introduced in the improved model. Comparisons of results from experiments and calculations with the previous model confirm the improved performance over the existing model. The rheological parameters obtained from the improved model show good resemblance to those obtained from a laboratory viscometer. The work also provides a reference to similar applications such as fluid transportation through pipelines where dynamic pressure dominates and therefore should be correctly predicted considering its velocity profile in a laminar condition.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Offshore and Dredging Engineerin
Thermal analysis of a miniature magnetic fluid seal installed in an implantable rotary pump
No full textThe capacity of a magnetic fluid (MF) seal is decreased by increased MF temperature. A cooling system for MF is limited in a miniature MF seal installed in an implantable rotary pump. MF temperature in an MF seal installed in an implantable rotary pump was studied. The temperature of MF in a rotary pump was measured in vitro. Also, steady-state thermal analyses were conducted for an implantable rotary pump model. The results showed that (1) the decrease in magnetization of an MF due to increased temperature is negligible when the heat transfer coefficient of the seal housing is greater than 500 W/(m2·K) and (2) the increased temperature is mainly due to heat flux from the motor, and the magnitude of temperature increase due to viscous friction in the MF is low. In conclusion, an MF seal can be used in an implantable rotary pump from the standpoint of heat characteristics
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