1,720,959 research outputs found
Perfil glicêmico em pacientes com fibrose cística e intervenção nutricional na fase de pré-diabetes
Get PDFA fibrose cística (FC) é uma doença genética autossômica recessiva. A patologia pulmonar é a característica central da FC, levando a várias consequências como a desnutrição e baixa massa óssea. O diabetes relacionado à fibrose cística (DRFC) é a comorbidade mais prevalente nestes pacientes e com alto índice de mortalidade. Objetivos: Avaliar o impacto das alterações glicêmicas no estado nutricional e declínio da função pulmonar de pacientes com FC que acompanham no Serviço de Pneumologia do Hospital de Clínicas de Porto Alegre (HCPA). Como segundo objetivo, avaliar a resposta glicêmica após aconselhamento nutricional atráves de uma dieta de baixo índice glicêmico em pacientes com pré-diabetes e FC. Métodos: esta defesa se divide em três capítulos: referencial téorico sobre o tema, um artigo de corte retrospectivo com todos os pacientes com FC em seguimento no HCPA, um segundo artigo realizado como um ensaio clínico randomizado (ECR). Resultados: No estudo retrospectivo, avaliamos um total de 175 pacientes, 59% apresentavam estado glicêmico alterado (classificados por qualquer alteração glicêmica). Estas alterações foram associadas com a piora da função pulmonar quando divididas pelos tercis da capacidade vital forçada (CVF) menor tercil <62%, status glicêmico alterado [n = 41 (71.9%); p = 0.03)], hemoglobina glicada (HbA1c) [n = 35 (68.6%); p = 0.01] DM [n = 13 (22.8%); p = 0.01]. Para a volume expiratório em 1 segundo (VEF1) menor tercil <56%, status glicêmico alterado [n = 37 (66.1%); p = 0.001] HbA1c [n = 31 (64.6%, p = 0.001)]. No ECR foram avaliados 22 pacientes, encontramos uma associação do maior consumo de fibras e melhor controle glicêmico no grupo que recebeu a intervenção (n=10) e isso foi associado com melhor função pulmonar nestes pacientes. VEF1% diferença (IC95%) pré e pós-intervenção -0,90(-4,05 a 2,25) p=0,57 e -5,18(-9,94 a -0,42) p=0,03 e CVF% (IC95%) -3,26(-7,80 a 1,28) p=0,15 e -6,2(10,2 a -2,21) p=0,002. Conclusão: As alterações glicêmicas estão associadas à piora da função pulmonar, bem como ao baixo peso. Uma dieta de baixo índice glicêmico com maior consumo de fibras pode ter efeito no controle da glicemia e estar associada com melhores desfechos pulmonares.Cystic fibrosis (CF) is an autosomal recessive genetic disease. Pulmonary pathology is the central feature of CF, leading to several consequences such as malnutrition and low bone mass. Diabetes related to cystic fibrosis (CFRD) is the most prevalent comorbidity in these patients and has a high mortality rate. Objectives: To assess the impact of glycemic changes on nutritional status and decline in lung function in CF patients who are followed up at the Pulmonology Service of Hospital de Clínicas de Porto Alegre (HCPA). As a second objective, to evaluate the glycemic response after nutritional counseling through a low glycemic index diet in patients with pre-diabetes and CF. Methods: this defense is divided into three chapters: theoretical framework on the topic, a retrospective article with all CF patients being followed up at HCPA, a second article carried out as a randomized clinical trial (RCT). Results: In the retrospective study, we evaluated a total of 175 patients, 59% had an altered glycemic status (classified by any glycemic alteration). These changes were associated with worsening lung function when divided by the tertiles of the forced vital capacity (FVC) lower tertile <62% altered glycemic status [n = 41 (71.9%); p = 0.03)], glycated hemoglobin (HbA1c) [n = 35 (68.6%); p = 0.01] DM [n = 13 (22.8%); p = 0.01]. For 1-second expiratory volume (FEV1) lower tertile <56%, altered glycemic status [n = 37 (66.1%); p = 0.001] HbA1c [n = 31 (64.6%, p = 0.001)]. In the RCT 22 patients were evaluated, we found an association of higher fiber consumption and better glycemic control in the group that received the intervention (n = 10) and this was associated with better lung function in these patients. FEV1% difference (95% CI) before and after intervention -0.90 (-4.05 to 2.25) p = 0.57 and -5.18 (-9.94 to -0.42) p = 0, 03 and FVC% (95% CI) -3.26 (-7.80 to 1.28) p = 0.15 and -6.2 (10.2 to -2.21) p = 0.002. Conclusion: Glycemic changes are associated with worsening lung function, as well as with low weight. A low glycemic index diet with higher fiber consumption can have an effect on glycemic control and be associated with better pulmonary outcomes
Avaliação dos ácidos graxos da dieta usual e adiponectina sérica em pacientes com Diabetes Melito tipo 1
Get PDFIntrodução: A adiponectina é uma proteína secretada pelo tecido adiposo, ela desempenha um papel essencial na resistência à insulina e tem funções antiinflamatórias e anti-aterogénicas. mudanças na dieta podem influenciar os níveis de adiponectina. Diferentes intervenções dietéticas, especialmente aquelas relacionadas à ingestão de ácidos graxos, têm sido relatadas como possíveis mediadores de níveis de adiponectina. Métodos: Estudo transversal com 122 indivíduos com diabetes tipo 1 (DM1). A ingestão alimentar foi avaliada por registro alimentar de 3 dias. Os níveis de adiponectina foram categorizados em tercis (T1, <10,26μg/ml; T2, 10,261-18,28 μg/ml; T3,> 18,281ug/ml). Resultados: A média de idade foi de 38±11 anos, com duração do diabetes média de 17 ± 9 anos. Após análise de regressão múltipla a relação cintura-quadril (RCQ) (r = -0,19, p = 0,03), idade (r = -0,22 p = 0,01), pressão arterial sistólica (PAS) (r = -0,27, p=0,002), pressão arterial diastólica (PAD) (r= -0,19, p=0,30), ingestão de lipídios totais (g) (r= -0,20, p=0,02), ingestão ácidos graxos saturados (AGS) (r= -0,25, P= 0,004), ácido graxo monoinsaturado (AGM) (r = -0,21, p=0,02), colesterol da dieta (mg) (r= -0,20, p= 0,021), ingestão de sódio (g) (r= -0,19, p=0,03) e taxa de excreção urinária de albumina (EUA) (mcg/24h) (r=0,26, p=0,02) foram significativamente correlacionados com os níveis de adiponectina, mesmo após o ajuste para idade, PAD e PAS, EUA, e RCQ em todos os modelos. Foram observadas associações inversas entre os níveis de adiponectina e ingestão do total AGS e suas frações. Maior diferença foi encontrada nos indivíduos do primeiro e terceiro tercis de adiponectina, com tendência para o aumento dos níveis conforme maior ingestão de AGS. Conclusões: O presente estudo sugere que o consumo elevado AGS pode ser associado com baixos níveis de adiponectina em pacientes com DM1
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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