1,720,988 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Elektrophysiologische Untersuchungen zur Regulation rekombinanter Kaliumkanäle durch Metabolite des Fettsäure- und Phosphoinositidstoffwechsels
Full text linkDie Familie der einwärtsgleichrichtenden (Kir) K+ Kanäle ist eine wichtige Klasse von K+ Kanälen, die an der Aufrechterhaltung des Ruhemembranpotentials, der Festlegung des Schwellenwertes für Aktionspotentiale und der K+ Homöostase maßgeblich beteiligt ist. In dieser Arbeit wurde die Regulation von Kir-Kanälen durch langkettige Fettsäure-Coenzym A Ester (LC-CoA) untersucht, deren intrazelluläre Konzentration in bestimmten Stoffwechselsituationen erhöht sein kann (z. B. bei Adipositas) und so möglicherweise die Entstehung eines Diabetes mellitus vom Typ II begünstigt. Unter Anwendung der “patch-clamp“-Technik konnte gezeigt werden, dass LC-CoA potente Inhibitoren aller getesteten Kir-Kanäle (Kir1.1, Kir2.1, Kir3.4, Kir7.1) darstellen und dass die Präsenz einer bestimmten Phosphatgruppe im Coenzym A Molekül entscheidend für die Wirkung an Kir-Kanälen ist. Des Weiteren sind die Länge der Fettsäurekette und die Potenz der Inhibition direkt korreliert. Am Kanalprotein selbst führt das Binden von LC-CoA zu strukturellen Veränderungen des Kanals, es konnten sowohl intra- als auch extrazelluläre Abschnitte als Teil einer Gating-Maschinerie identifiziert werden, die das Öffnen und Schließen des Kanals vermittelt. Die Untersuchungen implizieren eine direkte Verbindung aller Kir-Kanäle mit dem zellulären Fettsäuremetabolismus und dienen dem besseren Verständnis des komplexen Schaltverhaltens von Kir-Kanälen
A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes
No full textCrucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer from low-throughput and require considerable experimenter expertise. Automated patch-clamp (APC) approaches are more experimenter independent and offer high-throughput, but by design are predominantly limited to assays containing small, homogenous cells. In order to enable high-throughput APC assays on larger cells such as native cardiomyocytes isolated from mammalian hearts, we employed a fixed-well APC plate format. A broad range of detailed electrophysiological parameters including action potential, L-type calcium current and basal inward rectifier current were reliably acquired from isolated swine atrial and ventricular cardiomyocytes using APC. Effective pharmacological modulation also indicated that this technique is applicable for drug screening using native cardiomyocyte material. Furthermore, sequential acquisition of multiple parameters from a single cell was successful in a high throughput format, substantially increasing data richness and quantity per experimental run. When appropriately expanded, these protocols will provide a foundation for effective mechanistic and phenotyping studies of human cardiac electrophysiology. Utilizing scarce biopsy samples, regular high throughput characterization of primary cardiomyocytes using APC will facilitate drug development initiatives and personalized treatment strategies for a multitude of cardiac diseases
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Automated patch-clamp for high throughput characterization of subtype-specific induced pluripotent stem cell derived cardiomyocytes
No full text- …
