1,720,996 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Mutation analysis of the Prop-1- gene on children with hypoplastic adenohypophysis and ectopic neurohypophysis
No full textMolekulargenetische Untersuchungen der letzten 2 Jahrzehnte erbrachten weitreichende Einsichten in die Genese der hypophysären Insuffizienz, die sowohl als isolierter Wachstumshormonmangel, wie auch als kombinierter hypophysärer Hormonausfall auftreten kann. Isoliert wurden Transkriptionsfaktoren, die zeitlich während der Embryonalentwicklung der Hypophyse exprimiert werden und sowohl bei der Morphogenese und Organogenese der Hypophyse, als auch an der Differenzierung und Proliferation der hypohysären Zellreihen eine wesentliche Rolle spielen. Genetische Defekte im Bereich dieser Transkriptionsfaktoren können allerdings nicht nur zum endokrinen Phänotyp des hypophysären Hormonausfalls führen, sondern auch zum klinischen Bild der missgebildeten Hypophyse mit einer hypoplastischen Adenohypophyse und insbesondere einer ektopen Neurohypophyse. Die wichtigsten bisher bekannten Transkriptionsfaktoren sind HESX-1, LHX-1, LHX-4, Prop-1 und Pit-1.
In unserer Studie führten wir eine molekulargenetische Mutationsanalyse des Prop-1-Gens bei Patienten mit einer Ektopie der Neurohypophyse und einer hypophysären Insuffizienz durch. Wir postulierten einen ursächlichen Zusammenhang zwischen eines möglichen Gendefektes im Bereich der Prop-1- Sequenz und der ektopen Neurohypophyse. Dafür amplifizierten wir die Prop1-Sequenz aller Patienten mittels PCR und unterzogen die Amplifikate einer SSCP-Analyse. Alle dort auffälligen Sequenzen und die gesamte Homöodomäne aller Patienten wurden im weiteren Verlauf sequenziert.
Überraschenderweise konnte eine Mutation der Prop-1-Sequenz bei keiner der untersuchten Personen nachgewiesen werden.
Auch in vorausgegangenen Studien konnten bei Patienten mit einem nachgewiesenen Prop-1-Defekt normale, hypoplastische oder sogar tumorös veränderte Neurohypophysen gefunden werden, nie jedoch eine Ektopie. Genetische Defekte im Bereich der anderen, oben erwähnten Transkriptionsfaktoren konnten bei Patienten mit ektoper Neurohypophyse detektiert werden. So z.B. beim homöotischen Gen HESX-1 das auch in Zusammenhang mit der sogenannten septo-optischen Dysplasie steht, und auch beim LHX-4-Gen. Prop-1 dagegen ist sicher keine häufige Ursache für eine ektope Neurohypophyse.Molecular genetic studies over the past 2 decades brought huge understanding into the pathogenesis of hypopituitarism, which can occur as isolated growth hormone deficiency as well as combined pituitary hormone deficiency.We isolated transcription factors, which are implicated in early pituitary organogenesis and morphogenesis as well as in differentiation and proliferation of the five cell hypes in the mature anterior pituitary gland. Mutations in these transcription factors cannot only lead to the phenotype of pituitary hormone deficiency but also to clinical features such as a hypoplastic anterior pituitary gland and particularly an ectopic posterior pituitary gland. The most important transcription factors in our studies are HESX-1, LHX-1, LHX-4, Prop-1 and Pit-1.
In our studies we focussed on mutation analysis of the Prop-1 gene, in patients with an ectopic posterior pituitary gland and hormone deficiencies. We postulated a connection between mutationes in the pituitary-specific paire-like homeodomain transcription factor Prop-1 and an ectopic pituitary gland. Therefore we extracted genomic DNA from 5ml EDTA blood, which than was analyzed for mutations using PCR. The PCR product was than sequenced. Surprisingly a mutation in the transcription factor Prop-1 couldn't be find in any of the examined patients. In preceeding studies patients with proven gene defects of Prop-1 had normal or hypoplastic pituitary glands, but not ectopic ones. But there could be find gebe defects in other transcription factors mentioned above in patients with ectopic posterior pituitary, e.g. HESX-1. But PROP-1 defects are for sure not frequent cause of ectopic posterior pituitary
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Psychosoziale Evaluation der Behandlung des Kleinwuchses im Rahmen der Internationalen Genotropin-Langzeit-Untersuchung (IGLU)
No full textDispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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