110 research outputs found
Differential diagnosis of central hemangioma of maxilla: A rare case report
No full textCentral hemangioma of the maxilla is a rare entity. Although the mucosal and soft tissue lesions are readily suspected due to their clinical appearance, the intrabony lesions may be difficult to distinguish visually. Early diagnosis of central hemangioma with appropriate and efficient diagnostic modality can help in the effective and more conservative management of the condition, eliminating the risk of hemorrhage following biopsy. Here, we present a case of central hemangioma of the maxilla emphasizing on various radiographic differential diagnosis with advanced imaging techniques
Sam68 Is Required for Both NF-κB Activation and Apoptosis Signaling by the TNF Receptor
No full textThe RNA-binding protein Sam68 is implicated in various cellular processes including RNA metabolism, apoptosis, and signal transduction. Here we identify a role of Sam68 in TNF-induced NF-κB activation and apoptosis. We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RIP recruitment and ubiquitylation. It also impairs cIAP1 recruitment and maintenance of recruited TRAF2 at the TNF receptor. In its absence, activation of the TAK1-IKK kinase complex is defective, greatly reducing signal transduction. Sam68 is also found as a part of the TNF-induced cytoplasmic caspase-8-FADD complex. RIP is not recruited to this complex in Sam68 knockout cells, and caspase activation is virtually absent. These findings delineate previously unknown functions for Sam68 in the TNF signaling pathway, where it acts as a signaling adaptor both in the membrane-associated complex I and in the cytoplasmic complex II, regulating both NF-κB activation and apoptosis
Ion atom collision studies using 0 ̊ electron spectroscopy
No full textCall number: LD2668 .T4 PHYS 1989 P37Master of SciencePhysic
Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress
No full textHigh extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor kappa B (NF-kappa B) p65 species phosphorylated at serine-536, which is paralleled by the induction of a subset of inflammatory NF-kappa B p65-responsive genes, including inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and IL-1 beta. The PKR-mediated hyperinduction of iNOS decreases cell survival in mouse embryonic fibroblasts via mechanisms involving nitric oxide (NO) synthesis and posttranslational modification of proteins. Moreover, we demonstrate that the PKR inhibitor C16 ameliorates both iNOS amplification and disease-induced phenotypic breakdown of the intestinal epithelial barrier caused by an increase in extracellular osmolarity induced by dextran sodium sulfate (DSS) in vivo. Collectively, these findings indicate that PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress
OrpheusDB: an attempt towards data version control on relational database
No full textThis thesis will cover the deign, manual, and implementation detail of OrpheusDB.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-12-01The student, Sili Hui, accepted the attached license on 2016-12-06 at 22:28.The student, Sili Hui, submitted this Thesis for approval on 2016-12-06 at 22:34.This Thesis was approved for publication on 2016-12-07 at 09:14.DSpace SAF Submission Ingestion Package generated from Vireo submission #10439 on 2017-02-28 at 14:37:18Made available in DSpace on 2017-03-01T16:37:06Z (GMT). No. of bitstreams: 2
HUI-THESIS-2016.pdf: 370407 bytes, checksum: 5d25b70350d18de43d3eb78eb2ceacaa (MD5)
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Previous issue date: 2016-12-07Embargo set by: Seth Robbins for item 98627
Lift date: 2019-03-01T16:37:19Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 98627 on 2019-03-02T10:15:17Z
Role of bicarbonate as a pH buffer and electron sink in microbial dechlorination of chloroethenes
No full textAbstract Background Buffering to achieve pH control is crucial for successful trichloroethene (TCE) anaerobic bioremediation. Bicarbonate (HCO3−) is the natural buffer in groundwater and the buffer of choice in the laboratory and at contaminated sites undergoing biological treatment with organohalide respiring microorganisms. However, HCO3− also serves as the electron acceptor for hydrogenotrophic methanogens and hydrogenotrophic homoacetogens, two microbial groups competing with organohalide respirers for hydrogen (H2). We studied the effect of HCO3− as a buffering agent and the effect of HCO3−-consuming reactions in a range of concentrations (2.5-30 mM) with an initial pH of 7.5 in H2-fed TCE reductively dechlorinating communities containing Dehalococcoides, hydrogenotrophic methanogens, and hydrogenotrophic homoacetogens. Results Rate differences in TCE dechlorination were observed as a result of added varying HCO3− concentrations due to H2-fed electrons channeled towards methanogenesis and homoacetogenesis and pH increases (up to 8.7) from biological HCO3− consumption. Significantly faster dechlorination rates were noted at all HCO3− concentrations tested when the pH buffering was improved by providing 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) as an additional buffer. Electron balances and quantitative PCR revealed that methanogenesis was the main electron sink when the initial HCO3− concentrations were 2.5 and 5 mM, while homoacetogenesis was the dominant process and sink when 10 and 30 mM HCO3− were provided initially. Conclusions Our study reveals that HCO3− is an important variable for bioremediation of chloroethenes as it has a prominent role as an electron acceptor for methanogenesis and homoacetogenesis. It also illustrates the changes in rates and extent of reductive dechlorination resulting from the combined effect of electron donor competition stimulated by HCO3− and the changes in pH exerted by methanogens and homoacetogens.</p
Determination of Grassmann manifolds which are boundaries
No full textLet FGnk denote the Grassmann manifold of all k-dimensional (left) F-vector subspace of Fn for F = R, the reals, C, the complex numbers, or H the quaternions. The problem of determining which of the
Grassmannians bound was addressed by the author in [4]. Partial results were obtained in [4] for the case F = R, including a sufficient condition, due to A. Dold, on n and k for R Gnk to bound. Here, we show that Dold's condition is also necessary, and obtain a new proof of sufficiency using the methods of this paper, which cover the complex and quaternionic cases as well
Life Cycle Assessment (LCA) analysis of thin film Silicon-based HyET solar cells
No full textGiven the rising research of thin film solar cells in recent years, flexible technology has been proven to be more light weight and cost effective. As photovoltaics is increasingly becoming the front runner in sustainable energy production, concerns over the associated impacts of solar modules throughout their life cycle are also increasing. This study quantifies the environmental impacts through LCA analysis for Roll-to-Roll (R2R) production process of thin film flexible silicon-based solar modules manufactured by a Dutch company HyET in The Netherlands.This study considers three product lines over a life cycle demarcated into its manufacturing, encapsulation and installation. The three product lines (cases) are as follows.1. Single junction a-Si with 7% efficiency.2. a-Si/nc-Si tandem cell with 10% efficiency3. a-Si/nc-Si tandem cell with 12% efficiencyThe installation phase considers a rooftop setup of capacity of 2.1 kWp with Balance of System (BoS) components.LCA analysis is carried out on Simapro 9.1.0.11 following the guidelines and the framework of International Organization for Standardization ISO14044. The outcome of LCA analysis is measured in terms of Global Warming Potential (GWP), Primary Energy Demand (PED) and Energy Pay Back Time (EPBT). Ecoinvent 3.5 is used as the primary database for these analyses to select the inventory. GWP is assessed using the CML-IA baseline method while PED is assessed using Cumulative energy demand v1.11 method. Sensitivity analysis is done by changing the location of production and up-scaling capacity. The installation stage is observed to contribute the highest GWP and also has the highest PED on account of BoS components. The LCA analysis has demonstrated similar trends of GWP, PED for all three product lines. EPBT on the other hand, is longer for 10% tandem cell on account of relatively larger module area as compared to 12% tandem cell and also the relatively higher energy consumption as compared to the single junction cell. The choice of substrate material is seen to impact the assessment indicators significantly. Flexible glass is observed to be the optimal choice for large-scale production. The choice of encapsulant material also affects the indicators demonstrably. Sensitivity analysis shows a positive impact on the indicators through up-scaling, while the location is not established as a significant factor sufficiently under considered assumptions.This project describes about the Life Cycle Assessment analysis of thin film Silicon-based HyET solar cells and their comparison to different substrate technologiesElectrical Engineering | Sustainable Energy Technolog
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