1,721,094 research outputs found
NOVEL SMALL MOLECULES THAT BIND AND/OR MODULATE DIFFERENT FORMS OF TAU OLIGOMERS
No full textThe present invention relates to novel small molecules of Formulas I, II, III, IIIa, IIIb, and IV and pharmaceutically acceptable salts thereof, as well as the preparation and the use thereof
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
Full text linkAcknowledgements The authors are grateful to M Goedert (MRC Laboratory of Molecular Biology, Cambridge, UK) for ex-vivo paired helical filaments which were kindly contributed by Bernandino Ghetti (Indiana University, USA). The authors are very grateful to Urmi Sengupta, Nemil Bhatt and Rakez Kayed (University of Texas, USA) for providing ex-vivo tau oligomers. TEM work was performed at the University of Sussex’s Electron microscopy imaging centre (EMC), funded by the School of Life Sciences, the Wellcome Trust (095605/Z/11/A, 208348/Z/17/Z) and the RM Phillips Trust. The authors thank Dr Pascale Schellenberger for valuable support. Funding This work was supported by funding from Alzheimer’s Society [AS-PG-16b-010] awarded to LCS and funding MBM. MBM is funded by the Alzheimer’s Association. YA is supported by WisTa Laboratories Ltd (PAR1596). The work was supported by ARUK South Coast Network. GB was supported by European Molecular Biology Organisation (EMBO) Short-Term Fellowship award (EMBO-STF 7674). LCS is supported by BBSRC [BB/S003657/1]. Urmi Sengupta, Nemil Bhatt, Rakez Kayed acknowledge the funding that supports their contribution (NIH grants to R.K: R01 AG054025 and U24AG072458).Peer reviewe
Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
