1,694 research outputs found
QSAR prediction of aquatic and mammalian toxicity of triazoles and benzo-triazoles
No full textTriazoles and benzo triazoles (TAZ/BTAZ) are potentially hazardous chemicals that adversely affect humans and other non-target species, and are on the list of substances of very high concern (SVHC) in the European regulation of chemicals REACH.
TAZ/BTAZ are synthetic molecules used in various industrial processes (to obtain pharmaceuticals and agricultural products), and have a wide application as anti-corrosives, cleansing agents for textiles, flame retardants, photographic emulsions, etc...Furthermore they are abundantly used as components of liquid deicing agents for aircraft and airport runways. Because of their wide use they have been found distributed throughout the environment, mainly in water compartments. The amount of experimental data available for these molecules is insufficient for a comprehensive characterization of their environmental and toxicological profile and they have been included among the four classes of chemicals studied in the European FP7 Project CADASTER (CAse studies on the Development and Application of in Silico Techniques for Environmental hazard and Risk assessment).
In this study we investigated and modeled by QSAR different endpoints of interest to define the potential aquatic toxicological profile of hundreds of TAZ/BTAZ, and the possible correlations among their aquatic and mammalian toxicity. The studied end-points were: LC50 in Onchorhynchus Mykiss, EC50 in Daphnia Magna, and EC50 in algae. Data for mammalian acute toxicity in rat (LD50 oral exposure) were also investigated and modeled. Different theoretical molecular descriptors were calculated by different proprietary and freely available online software (DRAGON, Hyperchem, and the CADASTER online platform for the calculation of molecular descriptors – www.cadaster.eu). The endpoints of interest were modeled by multiple linear regression (MLR) and the Genetic Algorithm was used to select the relevant molecular descriptors by the MLR-Ordinary Least Squares (OLS) method. The best models were validated for their predictive performance using leave-one-out, bootstrap and the scrambling of the responses. External validation was also performed depending on the dimension of the studied experimental datasets. The reliability of the predictions was always checked by the leverage approach in order to verify the chemical applicability domain of the models
Memorandum : betr. die Sicherung und Erschliessung der Quellen zur juedischen Kulturgeschichte und Familienkunde.
No full textDocument about the proposed establishment of a center for German Jewish culture and genealogy in Berlin or HamburgdigitizedThe manuscript has been removed from the ‘Lehranstalt fuer die Wissenschaft des Judentums Collection’, AR 11844Born in Hamburg on February 26, 1896, Erna Magnus was a social worker who was engaged in an historical study of the Jewish community of Hamburg during the 1930s. She emigrated to the United States in 1939, where she held various social work and teaching position
Portrait of Paul Heyse.
No full textPhotograph of an oil painting by Eduard Magnus depicting the author, translator and Nobel laureate for literature (1910), Paul Johann Ludwig von Heyse.Digital ImageArtwork
Das rhetorische Ich: Hans Magnus Enzensbergers Selbstinszenierungen
No full textThe article discusses the rhetorical strategies underlying Hans Magnus Enzensberger's presentation of his work as an author, editor and poet
Das rhetorische Ich: Hans Magnus Enzensbergers Selbstinszenierungen
No full textThe article discusses the rhetorical strategies underlying Hans Magnus Enzensberger's presentation of his work as an author, editor and poet
Comparing consortial repositories: a model-driven analysis
No full textThis study aims to provide a comparative assessment of different repository consortia as a reference to inform future work in the area. A review of the literature was used to identify repository consortia, and their features were compared. Three models of consortial repositories were derived from this comparison, based on their structure and aims. The consortial models were based around either: creating a shared repository for the members, developing a repository software platform or creating a metadata harvesting service to aggregate content. Using case studies of each type of repository consortium, each model was assessed in terms of its particular strengths and weaknesses. These strengths were then compared across the models to enable those considering a consortial repository project to assess which model, or combination of models, would best address their needs and to aid in project planning
ARCHITECTURE AND URBAN DESIGN FOR THE AGEING SOCIETY, Review
No full textAuthor: Deane Simpson Young-Old: Urban Utopias of an Ageing Society, Zurich: Lars Müller Publishers, 2015 Reviewer: Magnus Rön
Training for Entrepreneurship and New Businesses
No full text An important part of governmental industrial policy is to support entrepreneurship and the creation of new businesses through various programmes. These are often organized at regional or local level by support organizations such as innovation centres (at universities), regional development funds and science parks. Earlier studies of business support structures have focused mainly on the ‘demand’ side; that is, on participants' perceptions of the usefulness of taking part in different support programmes. These studies have shown that there is a mismatch between the supply and demand side in business support activities. This paper deals with the supply side's view of organizing support activities for entrepreneurs and new businesses. The author analyses the responses to a questionnaire survey of business support organizations in Sweden. The results show that the support organizations are well aware of the problems the participants have – relating to, among other things, time, educational methods, finance, priorities, and access to information. At the same time, the support organizations disagree with suggestions that they are too theoretical in their teaching, lack experience in the problems of small businesses, offer inflexible programmes, have problems communicating, or lack teaching expertise (in, for example, training programmes). This paper discusses the gap in perception between the suppliers and their market and addresses the policy issues it raises. The implications for training for entrepreneurship and new businesses are also addressed. </jats:p
Med en svensk ärkebiskop i Rom : i Johannes Magnus fotspår
No full textThe article, published in Romhorisont, the journal of the Swedish Institute of Rome, links Johannes Magnus' (1488–1544) life to various places in Rome and offers a possible route in his footsteps. Photographies by the author
Numerical Simulation of Negative Magnus Force on a Rotating Sphere
No full textFlow characteristics and fluid force on a sphere rotating along with axis perpendicular to mean air flow were investigated using Large Eddy Simulation (LES) at two different Reynolds numbers Re_[p] of 1.0×10^[4] and 2.0×10^[5]. As a result of simulation, opposite flow characteristics around the sphere and displacement of the separation point were visualized depending on the Reynolds number even though rotation speed according to the Reynolds number is the same. When the sphere rotates at some specific rotation velocity and at Re_[p] = 1.0×10^[4], flow characteristics agree with the flow field explained in the Magnus effect. While sphere rotates at the same rotation velocity while increasing Re_[p] to 2.0×10^[5], separation point moves in opposite direction and wake appears in the different direction. The reason of the negative Magnus force was discussed in terms of the boundary layer transition on the surface
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