30,896 research outputs found
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
Get PDFGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
Get PDFChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation
Get PDFThermosolutal Convection of Natural and Anti-Natural Solutions Through an Angled Cavity Under Cross Gradients in Temperature and Concentration
No full textInstitutional Ownership and Corporate Social Performance: Empirical Evidence from Indonesian Companies
Get PDFPrior research on the relationships of institutional ownership and corporate social responsibility
has focused on North American (U.S. and Canada) and European companies. With the passage
of Indonesian Law No. 40 in 2007, Indonesian companies are now obligated to conduct CSP.
As these companies objected to the passage of this law, awareness of how CSP may benefit
Indonesian companies in terms of its positive impact on institutional investors needs to be in-
vestigated. Thus, this paper examines the relationships of IO and CSP for Indonesian compa-
nies. Unfortunately, contrary to the results for North American and European companies, we
found no relationships between institutional ownership and corporate social responsibility for
Indonesian companies. This finding suggests that most institutional investors do not include
CSP as part of their investment decisions.
Keywords: Institutional ownership, Corporate social performance (CSP), corporate social
responsibility (CSR), Indonesian companie
Perinatal and infant postmortem examination. Survey of women's reactions to perinatal necropsy
No full textHayati Abdul Rahman, T Y Khon
Fully Turbulent Mean Velocity Profile for Purely Viscous non-Newtonian Fluids
No full textThe characteristic near wall behavior of turbulent flow of purely-viscous non-Newtonian fluids is discussed for both power-law (P.-L.) and Herschel-Bulkley (H.-B.) rheological models. A proper scaling is presented for H.-B. fluids to establish an analogy with power-law fluids with same flow index. To provide reference data for turbulent flow of non-Newtonian fluids, DNS simulations of power-law fluids are conducted in a rectangular channel for a large range of power-law indices ( = 0.5, 0.69, 0.75, 0.9, 1, 1.2). The DNS data show that the mean velocity profile in the viscous and logarithmic layers follow expressions of the form and respectively, where shows a logarithmic dependency on the flow index.Comparison with some experimental data shows the above formulation to be valid for Reynolds numbers (based on shear velocity) as high as 1000
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
An Efficient Data Aggregation Algorithm for Cluster-based Sensor Network
Get PDFData aggregation in wireless sensor networks eliminates redundancy to improve bandwidth utilization and energy-efficiency of sensor nodes. One node, called the cluster leader, collects data from surrounding nodes and then sends the summarized information to upstream nodes. In this paper, we propose an algorithm to select a cluster leader that will perform data aggregation in a partially connected sensor network. The algorithm reduces the traffic flow inside the network by adaptively selecting the shortest route for packet routing to the cluster leader. We also describe a simulation framework for functional analysis of WSN applications taking our proposed algorithm as an exampl
Balancing contractual and relational approaches for PPP success and sustainability
No full textUseful synergies are targeted by proposing a convergence of hitherto parallel international endeavours towards: (1) developing better and sustainable relationships for more productive construction project teams, in general; and (2) optimising the necessarily long term contractual arrangements of PPPs in particular. Examples are drawn from Africa and Latin America to reinforce reported PPP experiences from other regions, in building up a case for injecting ‘relational contracting approaches’ in order to develop more productive and sustainable PPPs. Strong and sustainable relationships are shown to be essential, and complementary to appropriate contractual incentives, that would together empower PPP project teams to focus on developing sustainable infrastructure and ultimately on overall sustainable development. These propositions are merged into a basic model that merits further investigation and development, in order to ensure that planned PPPs benefit the community at large, in respect of both present and future generations
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