112,205 research outputs found
Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle
No full textThe potent immunomodulatory, anti-inflammatory and procoagulant properties of the
protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been
previously found to be modulated by a supramolecular monomer-trimer equilibrium.
More structural details that integrate experimental data into a predictive framework
have recently been reported. Unfortunately, homology modelling and fold-recognition
strategies were not successful in creating a theoretical model of the structural
organization of SV-IV. It was inferred that the global structure of SV-IV is not similar
to any protein of known three-dimensional structure. Reversing the classical approach
to the sequence-structure-function paradigm, in this paper we report on novel
information obtained by comparing physicochemical parameters of SV-IV with two
datasets made of intrinsically unfolded and ideally globular proteins. In addition, we
have analysed the SV-IV sequence by several publicly available disorder-oriented
predictors. Overall, disorder predictions and a re-examination of existing experimental
data strongly suggest that SV-IV needs large plasticity to efficiently interact with the
different targets that characterize its multifaceted biological function and should be
therefore better classified as an intrinsically disordered protein
Enti confessionali e licenziamento ideologico. Uno sguardo alla giurisprudenza della Corte di Strasburgo
No full textThe article provides an analysis of recent European Court of Human Rights’ legal cases about the ideological dismissal: Lombardi Vallauri v. Italy (2009), Obst v. Germany (2010), Schüth v. Germany (2010) and Siebenhaar v. Germany (2011). As the Directive 2000/78/EC within the EU context, these judgments state that, by virtue of the special nature of jobs where the employer is a religious entity, the employee is bound by a heightened duty of loyalty. This special bond of trust does not violate the Convention rights when the employee performs tasks that have a direct connection with the ethical aims pursued by the organization. However, it’s necessary to verify that neither the fundamental principles of domestic law nor the worker’s dignity are compromised by the required duties. Actually, the Court, on the one hand, protects the autonomy of Churches and religious organization, as well as the workers’ rights. On the other hand, it takes into account also the interests of third parties, in various way related to religious bodies, who are interested in maintaining the confessional identity of the latter (see Siebenhaar and the particular case of Fernandez Martinez v. Spain)
Recensione a V. Bazán (coord.), Derecho Procesal Constitucional Americano y Europeo, 2 voll., Abeledo Perrot, Buenos Aires, 2010
No full textRecensione a V. Bazán (coord.), Derecho Procesal Constitucional Americano y Europeo, 2 voll., Abeledo Perrot, Buenos Aires, 201
Church of Jesus Christ of Latter-day Sainst v. Uk: la Corte europea si pronuncia sul regime fiscale riservato dal Regno Unito al Tempio mormone di Preston
No full textAn Emerging Right to a “Gay” Family Life? The Case Oliari v. Italy in a Comparative Perspective
No full textThis Article analyses, through the lens of comparative law, the Oliari and others v. Italy judgment, which was issued by the European Court of Human Rights (ECtHR) in July 2015. The Oliari case is important for being the first judgment in which the ECtHR established the granting of legal “recognition and protection” to same-sex couples as a positive obligation for the Member States of the Council of Europe on the basis of Article 8 of the European Convention on Human Rights. In order to understand the role of judicial bodies in the progressive protection of homosexual rights, this Article combines an analysis of European case law with the national perspective. As it concerns the supranational facet, the authors illustrate Oliari’s reasoning and situate the case in the jurisprudence of the ECtHR. Elements of both continuity and innovation emerge from the analysis, as well as a relevant dimension of judicial dialogue supporting the incremental recognition of gay rights in Europe. As it concerns the national facet, this specific case was initially dealt with at the domestic level and was the object of judgment 138/2010 by the Italian Constitutional Court. The judgment is critically put into perspective through the examination of the jurisprudence of other European Constitutional Courts (France, Portugal and Spain) that were called on to decide similar cases in the same period. Therefore, the Article offers a comparative analysis of the Oliari judgment clarifying its relevance and speculating on the potential value of this case for the future recognition of the right to a “gay” family life in Europe
Temperature Effect on “Ragone Plots” of Lithium-Ion Batteries
No full textTemperature is a major factor affecting lithium-ion batteries (LIB) performances including power, energy and life. Energy density vs. power density (E(P)) charts known as “Ragone plots” are convenient charts for comparing the performance of energy storage systems (ESS) such as batteries, supercapacitors, fuel cells, flywheels, hydrogen and gasoline. Basically, Ragone plots allow one to determine the amount of energy E (Wh kg−1 and Wh l−1) an ESS may deliver under a constant power load P (W kg−1 and W l−1). In this study Ragone charts are achieved on commercial LIB cells at temperatures ranging from −20°C to + 55°C. Cells are first charged using CCCV protocol at C/10 up to 4.2 V at the ambient temperatures (∼25°C). Then cells are discharged isothermally at constant rates ranging from C/5 to 10 C. To account for varying power and temperature Ragone isotherms are integrated over the power range yielding a functional Integrated Energy-Power (∫PE(P)dP∣T−−−−−−−−−−−√2). The ratio of integrated areas at T and at 25°C gives the “Energy-Power Index” (EPI) (%). The EPI vs. T profile shows a linear increase between −10°C and 25°C then it makes a semi-plateau between 25°C and 55°C.Published versio
V-SOC4AS: A Vehicle-SOC for Improving Automotive Security
No full textIntegrating embedded systems into next-generation vehicles is proliferating as they increase safety, efficiency, and driving comfort. These functionalities are provided by hundreds of electronic control units (ECUs) that communicate with each other using various protocols that, if not properly designed, may be vulnerable to local or remote attacks. The paper presents a vehicle-security operation center for improving automotive security (V-SOC4AS) to enhance the detection, response, and prevention of cyber-attacks in the automotive context. The goal is to monitor in real-time each subsystem of intra-vehicle communication, that is controller area network (CAN), local interconnect network (LIN), FlexRay, media oriented systems transport (MOST), and Ethernet. Therefore, to achieve this goal, security information and event management (SIEM) was used to monitor and detect malicious attacks in intra-vehicle and inter-vehicle communications: messages transmitted between vehicle ECUs; infotainment and telematics systems, which provide passengers with entertainment capabilities and information about the vehicle system; and vehicular ports, which allow vehicles to connect to diagnostic devices, upload content of various types. As a result, this allows the automation and improvement of threat detection and incident response processes. Furthermore, the V-SOC4AS allows the classification of the received message as malicious and non-malicious and acquisition of additional information about the type of attack. Thus, this reduces the detection time and provides more support for response activities. Experimental evaluation was conducted on two state-of-the-art attacks: denial of service (DoS) and fuzzing. An open-source dataset was used to simulate the vehicles. V-SOC4AS exploits security information and event management to analyze the packets sent by a vehicle using a rule-based mechanism. If the payload contains a CAN frame attack, it is notified to the SOC analysts
Trattamenti sperimentali nella tendinopatia della cuffia dei rotatori. P. Randelli, S. De Giorgi, V. Ragone, A. Menon, A. Castagna, pp71-82 In Il tendine e il muscolo. G. Peretti, GL Canata, CIC Edizioni Internazionali.
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