103,154 research outputs found
Supplemental Material for Raghavan et al., 2018
No full textThis file contains all of the supplemental Figures (S1-S6) and Tables (S1-S7) in Raghavan et al., "Incompatibilities in mismatch repair genes MLH1-PMS1 contribute to a wide range of mutation rates in human isolates of baker's yeast."<br
Equivariant Schubert Calculus
No full textWe describe T -equivariant Schubert calculus on G(k, n), T being an n-dimensio- nal torus, through derivations on the exterior algebra of a free A-module of rank n, where A is the T-equivariant cohomology of a point. In particular, T-equivariant Pieri's formulas are determined, answering a question raised by Lakshmibai, Raghavan and Sankaran (Equivariant Gi- ambelli and determinantal restriction formulas for the Grassmannian, Pure Appl. Math. Quart. 2 (2006), 699-717
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Optimal strategy sets for continuous two-person games
No full textIn the zero-sum (non-zero sum) completely mixed game each player has only one optimal (equilibrium) strategy (Parthasarathy and Raghavan, 1971). It is known that even for a three person completely mixed finite game the equilibrium set may contain more than one point (Chin, Parthasarathy and Raghavan, 1974). For continuous two person zero-sum games, it is known that there can be more than one optimal strategy even if the game is completely mixed
Optimal strategy sets for continuous two-person games
No full textIn the zero-sum (non-zero sum) completely mixed game each player has only one optimal (equilibrium) strategy (Parthasarathy and Raghavan, 1971). It is known that even for a three person completely mixed finite game the equilibrium set may contain more than one point (Chin, Parthasarathy and Raghavan, 1974). For continuous two person zero-sum games, it is known that there can be more than one optimal strategy even if the game is completely mixed
Need of a Digital Library for Indian Theses and Dissertations : a model on par with the ETD initiatives at International Level
No full textIn India, a strong move to digitize the internal sources of libraries in universities and other academic institutions yet to take place, which have a rich, precious and unique sources of information is hidden, even unlocked, like theses and dissertations. The idea of E- Theses and Dissertations (ETD) is coming up in International scenario, which can be easily located, readily accessible and delivered over the web. INFLIBNET as the only agency to take care the automation of academic libraries, established by UGC, has to further the existing achievements and to play a role in creating digital library of theses and dissertation to start with. In this paper the works done by INFLIBNET so far in this direction are cited with a proposal for a digital library of Indian theses and dissertations
Eurindicus Grave & Arjun & Raghavan 2018, gen. nov.
No full text<i>Eurindicus</i> gen. nov. <p> <b>Type species.</b> <i>Eurindicus bhugarbha</i> <b>sp. nov</b>., by present designation and monotypy.</p> <p> <b>Differential diagnosis.</b> RoStrum Smooth, non-dentate on both dorSal and Ventral marginS; diSto-meSial region of ocular peduncleS not anteriorly produced. Fourth thoracic Sternite (maleS) without tranSVerSal ridge or tooth; fifth thoracic Sternite with well-deVeloped tranSVerSal ridge. Upper antennular flagellum biramouS; fuSed portion compriSed of three diViSionS; acceSSory ramuS with four diViSionS; aeSthetaScS on Sub-diStal and diStal diViSion. Third maxilliped with two arthrobranchS. CarpuS of third and fourth pereiopod without cuSpidate Setae on diStoVentral margin; carpuS of third to fifth pereiopod without cuSpidate Setae on dorSal margin. Male Second pleopod with endopod Spatulate, not modified into gonopod, appendix maSculina preSent. Uropodal exopodS with Single cuSpidate Seta on diareSiS, protopod with weakly deVeloped lateral extenSion.</p> <p> <b>Etymology.</b> <i>Eurindicus</i> iS an arbitrary combination of ‘ <i>Eur-</i> ’ the firSt three letterS of the family Euryrhynchidae, and ‘- <i>indicus</i> ’, from India, baSed on the geographic diStribution of the genuS, thiS being the firSt record of the family in India; gender maSculine.</p> <p> <b>Systematic remarks.</b> A number of morphological featureS eaSily allow the new genuS to be placed within Euryrhynchidae. Notably, theSe are the Shape and form of the frontal region of the carapace, including the roStrum; the Shape of the eyeS; the form of the acceSSory ramuS of the upper antennular flagellum; the Shape and ornamentation of the telSon; the characteriStic tranSVerSe ridge on the fifth thoracic Sternite and the lower Surface of the palm and fixed finger of the firSt pereiopod with a well-deVeloped tuft of Serrate Setae. DeSpite the preSence of theSe putatiVe SynapomorphieS, <i>Eurindicus</i> <b>gen. nov.</b> occupieS an iSolated poSition within the family on account of the upper antennular flagellum and itS acceSSory ramuS being joined oVer three diViSionS (VS. one in all other genera), the preSence of a carpo-propodal bruSh, albeit reduced (VS. abSent in all other genera) and the welldeVeloped branchioStegal grooVe (VS. abSent or poorly deVeloped in all other genera). A further difference with all known genera iS the poorly deVeloped poStero-lateral expanSion on the protopod of the uropod (VS. well-deVeloped in all other genera). The new genuS alSo diSplayS a primitiVe gill formula with pleurobranchS on all ambulatory pereiopodS aS well aS two arthrobranchS on the third maxilliped, only Shared with the WeSt African Surface dwelling <i>Euryrhynchoides</i> (VS. fewer gillS in the other genera, See Pachelle & TaVareS 2018).</p> <p> Due to the abSence of comprehenSiVe phylogenetic coVerage encompaSSing all genera, the exact SyStematic poSition of <i>Eurindicus</i> <b>gen. nov.</b> within Euryrhynchidae cannot herein be reSolVed. HoweVer, the morphological differenceS highlighted aboVe would indicate the genuS to be more likely to be baSal and perhapS moSt cloSely related to the WeSt African genuS <i>Euryrhynchina</i> with which it ShareS a number of potential SynapomorphieS (endopod of Second male pleopod Spatulate, low number of SpineS on uropodal diareSiS, abSence of Spiniform Setae on the dorSal margin of the dactyli of the third to fifth pereiopodS), although it differS SubStantially from that genuS in the branchial formula, the number of fuSed articleS, aS well aS the number and diSpoSition of the aeSthetaScS on the acceSSory ramuS of the antennular flagellum and the preSence of an appendix interna on the male firSt pleopod.</p> <p> A number of preViouS StudieS haVe poStulated that the WeSt African freShwater family DeSmocarididae could be the SiSter-taxon to Euryrhynchidae, baSed on morphology (De GraVe 2007) aS well aS phylogeneticS (Bracken <i>et al</i>. 2009; Kou <i>et al</i>. 2013; De GraVe <i>et al</i>. 2015a). The preSence of a well-deVeloped branchioStegal grooVe in <i>Eurindicus</i> <b>gen. nov.</b> iS howeVer reminiScent of the poSt-antennular Suture in Typhlocarididae, with a clear potential for homology. Although the acceSSory ramuS of the upper antennular flagellum in <i>Eurindicus</i> <b>gen. nov.</b> iS clearly homologouS with that obSerVed in the other euryrhynchid genera, the fact that it iS joined oVer three diViSionS with the flagellum may further Support a cloSe relationShip to Typhlocarididae.</p> <p> Sankolli and Shenoy (1979) deScribed a new genuS and SpecieS of Subterranean Shrimp, <i>Troglindicus phreaticus</i> from a coaStal well in Ratnagiri, MaharaShtra State, which they aSSumed waS allied to the Cuban, Subterranean genuS <i>Troglocubanus</i> HolthuiS, 1949 and thuS placed in Palaemonidae. Pereira (1997) included thiS genuS in hiS cladiStic Study of Palaemonidae <i>sensu lato</i> and reSolVed the taxon to be cloSely related to Euryrhynchidae, albeit in a baSally unreSolVed clade which alSo contained <i>Troglocubanus</i>, <i>Typhlocaris</i> Calman, 1909 and <i>Creaseria</i> HolthuiS, 1950. No further StudieS haVe examined the SyStematic poSition of thiS genuS, which waS herein undertaken giVen the geographic proximity and Similar habitat to the type locality of <i>Eurindicus</i> <b>gen. nov.</b> BaSed on a direct examination of four paratypeS (RMNH D 35320) it iS eVident that <i>T. phreaticus</i> ShareS a number of putatiVe SynapomorphieS with Euryrhynchidae, notably the preSence of a well-deVeloped tranSVerSe ridge on the fifth thoracic Sternite, the well-deVeloped bruSh on the palm and fixed finger of the firSt pereiopod, a well-deVeloped poStero-lateral expanSion on the protopod of the uropod (leSS deVeloped in <i>Eurindicus</i> <b>gen. nov.</b>) and the Shape and ornamentation of the telSon, with itS typical euryrhynchid diStal margin. HoweVer, it iS noticeably different in the form of the acceSSory ramuS of the upper antennular flagellum, which conSiStS of 15 free, non-conical diViSionS with 2-3 pairS of aeSthetaScS on all diViSionS. Two further SimilaritieS Shared with <i>Eurindicus</i> <b>gen. nov.</b> are that the joined portion of the upper antennular flagellum conSiStS of three diViSionS and the preSence of a well-defined branchioStegal grooVe. It iS thuS SeemS eVident that <i>Troglindicus</i> iS phylogenetically cloSely allied to Euryrhynchidae. HoweVer, the genuS iS herein not formally tranSferred to that family, aS that would negate a further defining Synapomorphy of Euryrhynchidae, notably the unique Shape of the acceSSory ramuS of the upper antennular flagellum. NeVertheleSS, aS a preViouSly SuggeSted Synapomorphy, the Single jointed diViSion in the upper antennular flagellum, waS negated by the diScoVery of <i>Eurindicus</i> <b>gen. nov.</b>, it iS unclear where the true circumScription of the family now lieS. GiVen the high leVel of morphological homoplaSieS at higher SyStematic leVelS within Caridea, thiS can only be fully reSolVed by a targeted molecular phylogenetic approach.</p>Published as part of <i>Grave, Sammy De, Arjun, Charambilly Purushothaman & Raghavan, Rajeev, 2018, The discovery of Euryrhynchidae (Crustacea: Decapoda) in India, with the description of a new genus and species, pp. 367-378 in Zootaxa 4462 (3)</i> on page 369, DOI: 10.11646/zootaxa.4462.3.4, <a href="http://zenodo.org/record/1441701">http://zenodo.org/record/1441701</a>
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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