1,753 research outputs found
Filip Spannbrucker
No full textFilip Spannbrucker Filip Spannbrucker, česká barokní architektura, hrabě František Josef Schlik, Jean Baptiste Mathey, Jičínsko The main aim of this thesis is to present the life and work of Filip Spannbrucker (approximately 1672?1729), Prague architect and builder, in the context of contemporary artistic and social course of events. In the first part of this work there will be outlined Spannbrucker's life and professional career based on elaborate archival research. Special attention will be devoted to proprietors and a patronage of building projects wherein Spannbrucker participated or whereof was an author. In the connection, his work will be brought in contiguity of contemporaneous cultural, socioeconomical and aesthetical notions and relations. In the second part of this thesis there will be pointed out a characteristic and spring of inspiration of Spannbrucker's architecture by means of an accurate formal analysis. Final part will be a catalog of Filip Spannbrucker's works. Filip Spannbrucker, Czech baroque architecture, count František Josef Schlik, Jean Baptiste Mathey, region of Jičí
Location-Based Discovery and Network Handover Management for Heterogeneous IEEE 802.11ah IoT Applications
No full textThis research was funded by the Flemish IDEAL-IoT project (FWO SBO, grant nr. S004017N). The author Serena Santi is funded by the Flemish FWO SB grant (nr. 1S82120N). The author Filip Lemic was supported by the EU MSCA grant (nr. 893760). The computational resources were provided by the VSC (Flemish Supercomputer Center), funded by FWO and the Flemish Government -department EWI
Bacteria-targeting nanoparticles for managing infections
No full textThesis (Ph. D. in Chemical and Biomedical Engineering)--Harvard-MIT Program in Health Sciences and Technology, 2013.Cataloged from PDF version of thesis.Includes bibliographical references.Bacterial infections continue to be a significant concern particularly in healthcare settings and in the developing world. Current challenges include the increasing spread of drug resistant (DR) organisms, the side effects of antibiotic therapy, the negative consequences of clearing the commensal bacterial flora, and difficulties in developing prophylactic vaccines. This thesis was an investigation of the potential of a class of polymeric nanoparticles (NP) to contribute to the management of bacterial infections. More specifically, steps were taken towards using these NPs (1) to achieve greater spatiotemporal control over drug therapy by more targeted antibiotic delivery to bacteria, and (2) to develop a prophylactic vaccine formulation against the common bacterial sexually transmitted disease (STD) caused by Chlamydia trachomatis. In the first part, we synthesized polymeric NPs containing poly(lactic-co-glycolic acid)- block-poly(L-histidine)-block-poly(ethylene glycol) (PLGA-PLH-PEG). We show that these NPs are able to bind to bacteria under model acidic infection conditions and are able to encapsulate and deliver vancomycin to inhibit the growth of Staphylococcus aureus bacteria in vitro. Further work showed that the PLGA-PLH-PEG-based NPs demonstrated the potential for competition for binding bacteria at a site of infection from soluble protein and model phagocytic and tissue-resident cells in a NP composition dependent manner. The NPs demonstrated low toxicity in vitro, were well tolerated by mice in vivo, and circulated in the blood on timescales comparable to control PLGA-PEG NPs. In the second part, we used PLGA-PLH-PEG-based NPs to design a prophylactic vaccine against the obligate intracellular bacterium Chlamydia trachomatis, the most common cause of bacterial STD in the world. Currently, no vaccines against this pathogen are approved for use in humans. We first formulated NPs encapsulating the TLR7 agonist R848 conjugated to poly(lactic acid) (R848-PLA) in PLGA-PLH-PEG-based NPs, then incubated these R848-NPs with UV-inactivated C. trachomatis bacteria in acidity, forming a construct. Mice immunized with this vaccine via genital or intranasal routes demonstrated protection from genital infection post immunization in a primarily CD4⁺ T cell-dependent manner. These results may suggest avenues for future work in designing and developing more targeted drug therapies or vaccine formulations for managing bacterial infections using polymeric nanoparticles.by Aleksandar Filip Radovic-Moreno.Ph.D.in Chemical and Biomedical Engineerin
Modular System for Distributed User Data Management
No full textTitle: Modular System for Distributed User Data Management Author: Filip Pavliš, Author's email: [email protected] Department: Department of Distributed and Dependable Systems Supervisor: Mgr. Pavel Ježek, Department of Distributed and Dependable Systems Abstract: The main objective of this project was to create a multiplatform modular system for distributed data management. The system supports both local and remote accessible data storage. Therefore a part of the solution is also a server for remote data access. System also provides parallel usage of a local and remote storage which guarantees that the storage is accessible also when connection to server is lost. In this case, system is capable to synchronize changes between the server and a client. A client can use multiple instances of his storage and our system is able to synchronize them through central server. The system provides abstraction over data model to separate plugin developers from its specific behavior. As practical preview of system usability was created an extension application called TuaLoca. The application will contain implementation of preview plugins and basic user interaction. Keywords: Distributed Data Management, Modular system, Synchronization on the SQL Queries Level, Distributed Solution for Interface LIN
Heritage book from Mircea Filip collection
No full textMircea Filip collection were integrated in the Scientific Library in 2016. It contains patrimony of great importance. The author invites readers to an exciting journey into the world of books, gathered in a life of Man, to discover together their charm and wisdom, the spirit of the characters created in different time spaces. True biblical values have today become the books on which the dedication or Ex-Libris of the author is preserved
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