196,918 research outputs found
Estimativa da dose de radia??o m?dia recebida por pacientes internados na UTI
No full textObjetivos: Estimar a dose efetiva m?dia de radia??o ionizante que os pacientes recebem durante interna??o em Unidade de Terapia Intensiva (UTI) de um hospital geral do interior do Brasil e comparar os resultados com a literatura. M?todos: Trata-se de um estudo transversal retrospectivo. Os dados foram coletados na UTI Central do Hospital S?o Vicente de Paulo-Unidade I, de Passo Fundo, RS-BR. Foram analisados prontu?rios de 100 pacientes internados em 2017. As vari?veis coletadas foram idade, sexo, n?mero de dias de interna??o no setor, tipo e quantidade de exame radiol?gico realizado, segmento do corpo examinado e, posteriormente, estimou-se a dose m?dia de radia??o para cada paciente. Resultados: Os pacientes foram submetidos a um total de 987 exames de imagem, sendo 919 radiografias (93,11%) e 68 tomografias computadorizadas (6,88%). Em m?dia, os pacientes permaneceram internados 9,78 (DP?7,0) dias e realizaram 9,87 (DP?7,80) exames. A estimativa de dose efetiva m?dia por paciente foi de 3,56 (DP?4,46) mSv, com intervalo de 0,06mSv a 22,840mSv. Foram realizadas 735 radiografias de t?rax que representaram 74,47% dos exames solicitados e 4,13% de toda a radia??o ionizante cumulativa do per?odo (355,960mSv). As 155 radiografias de abdome realizadas representaram 15,70 % dos exames solicitados e 30,48% da radia??o total. Conclus?o: Considerando-se o limite de dose di?ria de 0,055mSv, conforme o limite de dose anual de 20mSv (CNEN NN 3.01), a estimativa da dose efetiva m?dia di?ria encontrada neste estudo excede em mais de 6 vezes o limite superior considerado in?cuo
Efeitos da radia??o UV sobre as termina??es nervosas da pele humana
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Previous issue date: 2008-03-31Introdu??o: Atualmente, devido ? polui??o e emiss?o de gases t?xicos, h? uma degrada??o gradual da camada de oz?nio que filtra uma grande parcela das emiss?es UV. A radia??o UV altera significativamente as estruturas da pele, incluindo as termina??es nervosas. Em decorr?ncia do crescente aumento de doen?as de pele relacionadas ? exposi??o UV, faz-se necess?ria a avalia??o da efetividade de novos princ?pios ativos com finalidade de prote??o contra as radia??es. Estudos anteriores n?o foram capazes de quantificar o dano induzido pela radia??o UV nas termina??es nervosas. Objetivos: identificar as termina??es nervosas na pele humana, quantificar os efeitos das radia??es UV sobre as termina??es nervosas e verificar o efeito de princ?pios ativos neuroprotetores ? exposi??o UV. Materiais e M?todos: bi?psias de pele, de 35 adultos saud?veis, sob cirurgia pl?stica, foram obtidas e imediatamente tratadas com tr?s emuls?es: Creme1, Creme2 (placebo) e FPS 15. As amostras tratadas com as emuls?es ou controle (sem creme) foram submetidos ? exposi??o UVA e UVB por 60 min. Sec??es de 15 m foram produzidas no criostato a partir de tecidos congelados e as estruturas nervosas foram identificadas por imunofluoresc?ncia utilizando um anticorpo monoclonal anti-CD56 (NCAM) humano. O dano nas termina??es foi identificado a partir da sele??o autom?tica de pixels (verde FITC) das imagens capturadas. Resultados: foram identificadas v?rias estruturas nervosas na pele, incluindo termina??es livres, inerva??es do fol?culo piloso e gl?ndulas seb?ceas. As radia??es UVA e UVB reduziram, significativamente (40-60%), a densidade das termina??es nervosas na pele nas amostras controle, tratadas com placebo ou FPS 15 (p 0.05). Discuss?o: A quantifica??o dos danos celulares induzidos pela radia??o UV possibilita a identifica??o de compostos ativos com propriedades neuroprotetoras. Os mecanismos de dano celular bem como as atividades neuroprotetoras merecem ser identificadas nos pr?ximos estudos
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
RADIA: RNA and DNA integrated analysis for somatic mutation detection
No full textThe detection of somatic single nucleotide variants is a crucial component to the characterization of the cancer genome. Mutation calling algorithms thus far have focused on comparing the normal and tumor genomes from the same individual. In recent years, it has become routine for projects like The Cancer Genome Atlas (TCGA) to also sequence the tumor RNA. Here we present RADIA (RNA and DNA Integrated Analysis), a novel computational method combining the patient-matched normal and tumor DNA with the tumor RNA to detect somatic mutations. The inclusion of the RNA increases the power to detect somatic mutations, especially at low DNA allelic frequencies. By integrating an individual's DNA and RNA, we are able to detect mutations that would otherwise be missed by traditional algorithms that examine only the DNA. We demonstrate high sensitivity (84%) and very high precision (98% and 99%) for RADIA in patient data from endometrial carcinoma and lung adenocarcinoma from TCGA. Mutations with both high DNA and RNA read support have the highest validation rate of over 99%. We also introduce a simulation package that spikes in artificial mutations to patient data, rather than simulating sequencing data from a reference genome. We evaluate sensitivity on the simulation data and demonstrate our ability to rescue back mutations at low DNA allelic frequencies by including the RNA. Finally, we highlight mutations in important cancer genes that were rescued due to the incorporation of the RNA. Copyright
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Radia??o UV-C no controle de Tetranychus Urticae (?caro rajado) na cultura do morangueiro
No full textThe culture of strawberry (fragaria x ananassa) has conquered much space in the Brazilian market, this occurs by the high acceptance of the Brazilian and world population, by the consumption of this pseudofruit is in natura, in short majority. The market trend has been the production in protected environments, a condition that allows increased productivity, however, with some disadvantages. Among them, due to high temperature and low humidity, the incidence of Tetranychus urticae (spider
mite) is favored in this type of cultivation, being considered the main pest of the strawberry crop. The main form of control, currently, is the application of pesticides, a management with high persistence and high risk of environmental contamination. UVC radiation (254 nm) has proven to be an efficient alternative to the use of pesticides because it has a germicidal effect. Therefore, by being able to kill several phytopathogenic organisms, such as fungi, bacteria, protozoa and arthropods, it shows itself as a possibility to control Tetranychus urticae. This technology has the advantage of not leaving residues in the environment, therefore being a good alternative for systems that limit or prohibit the use of pesticides. Thus, we sought to evaluate the field efficiency of UV-C radiation in the control of T. urticae in strawberry crop, emitted by a 55 watt UV lamp. The experiment was carried out in a commercial strawberry production and consisted of making applications of UV-C radiation, through an equipment developed for the research. Four treatments were used: T0 - did not receive radiation; T1 - applications every 24h, cumulative dose: 1.925 kJ m?; T2 - applications every 48h, cumulative dose: 1.1 kJ m?; T3 - applications every 72h, cumulative dose: 0.825 kJ m?. Based on the treatments, the spider mite populations were evaluated, as well as the coloration of the trifoliants as a function of the cumulative effect of UV-C radiation. The results point out that there were significant differences among
treatments regarding the control of T. urticae populations, proportionally to the cumulative effect of the highest dose applied. Also, the cumulative effect of UV-C radiation had an effect on the coloration of the trifolium, and the highest cumulative dose was the one that presented darker shades of green, a result that may be somehow related to the resistance of the plant to pathogens. Thus, it is possible to
infer that UV-C light reduces the populations of spider mite and triggers the increase of pigmenting compounds in the leaves. Treatment 1 (daily applications), equivalent to 1.925 kJ m? of accumulated radiation, showed a 68.9% reduction in the number of mites than the control, as well as promoting the darkening of the trifolium.A cultura do morangueiro (fragaria x ananassa) tem conquistado muito espa?o no mercado brasileiro, isso ocorre pela alta aceita??o da popula??o brasileira e mundial, pelo consumo deste pseudofruto ser in natura, em suma maioria. A tend?ncia de mercado tem sido a produ??o em ambientes protegidos, condi??o essa, que permite o aumento da produtividade, contudo, com algumas desvantagens. Dentre elas, em fun??o de temperatura elevada e baixa umidade, a incid?ncia de Tetranychus urticae (?caro-rajado) nesse tipo de cultivo ? favorecida, sendo considerada a principal praga da cultura do morangueiro. A principal forma de controle, atualmente, ? a aplica??o de agrot?xicos, sendo um manejo com alta persist?ncia e grande risco de contamina??o ambiental. A radia??o UV-C (254 nm) tem se mostrado uma eficiente alternativa ao uso de agrot?xicos por ter efeito germicida. Portanto, por ser capaz de matar diversos organismo fitopatog?nicos, como fungos, bact?rias, protozo?rios e artr?podes, mostra-se como uma possibilidade de controlar Tetranychus urticae. Esta tecnologia tem como vantagem n?o deixar res?duos ao meio ambiente, portanto sendo uma boa alternativa para sistemas que limitam ou pro?bem o uso de agrot?xicos. Deste modo, buscou-se avaliar a efici?ncia a campo da radia??o UV-C no controle de T. urticae na cultura do morangueiro, emitida por uma l?mpada UV de 55 watts. O experimento foi realizado em uma produ??o comercial de morangos e consistiu em fazer aplica??es de radia??o UV-C, atrav?s de um equipamento desenvolvido para a pesquisa. Foram utilizados 4 tratamentos: T0 ? n?o recebeu radia??o; T1 ? aplica??es a cada 24h, dose acumulada: 1,925 kJ m?; T2 ? aplica??es a cada 48h, dose acumulada: 1,1 kJ m?; T3 ? aplica??es a cada 72h, dose acumulada: 0,825 kJ m?. A partir dos tratamentos, avaliou-se as popula??es de ?caro-rajado, bem como a colora??o dos trif?lios em fun??o do efeito cumulativo de radia??o UV-C. Os resultados apontam que houveram diferen?as significativas entre os tratamentos no que diz respeito ao controle das popula??es de T. urticae, de forma proporcional ao efeito acumulativo da maior dose aplicada. Tamb?m, o efeito cumulativo da radia??o UV-C pode contribuir sobre a colora??o dos trif?lios, sendo que a maior dose acumulada foi a que apresentou tons mais escuros de verde, resultado que pode estar de algum modo relacionado ? resist?ncia da planta ? pat?genos. Assim, ? poss?vel inferir que a luz UV-C reduz as popula??es de ?caro-rajado e desencadeia o aumento dos compostos pigmentantes nas folhas, sendo que o Tratamento 1 (aplica??es di?rias), equivalente a 1,925 kJ m? de radia??o acumulada, apresentou redu??o de 68,9% do n?mero de ?caros que a testemunha, bem como promoveu o escurecimento dos trif?lios
Sensitivity of RADIA on simulation data.
No full text<p>Artificial mutations were spiked into the tumor DNA and RNA BAM files of a breast cancer patient using bamsurgeon. (A) Mutations were spiked into the DNA at variant allele frequencies distributed from 1–50% and into the RNA at a constant 25%. The overall sensitivity of RADIA was 85%. RNA Rescue calls from the Triple BAM method detected the mutations that had a DNA VAF less than 10%. (B) Mutations were spiked into the DNA at 10% or less and into the RNA distributed from 1–50%. Most of the DOM mutations are filtered due to the low DNA allelic frequency. The mutations that have adequate RNA read support are rescued back at these low DNA allelic frequencies.</p
M?todos rastre?vel para determina??o da solidez da cor em couros
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Previous issue date: 2008-08-29O couro pode sofrer altera??es de cor devido a presen?a da radia??o UV solar que incide na superficie do nosso planeta. A susceptibilidade da cor ? radia??o ultravioleta ? conhecida tecnicamente como envelhecimento. O envelhecimento, associado ? resist?ncia da cor ? radia??o, est? classificado pelo grau da solidez da cor em couros, dada pela NBR 14730. Esta norma est? baseada em m?todos visuais, os quais determinam a dose de exposi??o ? radia??o e a varia??o do contraste, tendo como refer?ncia as escalas de padr?es de azul e cinza. O m?todo proposto para avaliar o envelhecimento da cor est? baseado em m?todos de medi??o rastre?veis e automatizados para a dose de exposi??o ? radia??o e para a classifica??o da mudan?a de cor. Esse m?todo minimiza a gera??o de erros de medi??o, permitindo acessibilidade e comparabilidade metrol?gica
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