327,980 research outputs found
Review of Generalized Latent Variable Modeling by Skrondal and Rabe-Hesketh
No full textThe new book by Skrondal and Rabe-Hesketh (2004) is reviewed.GLLAMM, generalized linear latent and mixed models, latent variables
Kontrazeption bei Frauen mit Migräne
No full textDer Bedarf nach sicherer Verhütung sollte keiner Patientin gesundheitlich schaden. Ziel bei Frauen mit Migräne muss es sein, eine Verhütungsmethode zu finden, die weder assoziiert ist mit einem erhöhten Insultrisiko, noch den Migräneverlauf negativ beeinflusst. Hier empfiehlt es sich in 3 Schritten vorzugehen. An erster Stelle steht die genaue Diagnostik und Einordnung der Kopfschmerzen. (Differentialdiagnose: Kopfschmerzen, Migräne ohne Aura, Migräne mit Aura). Hierzu bieten die untenstehenden Tabellen eine Hilfe. Die nächsten Schritte sind die Anamnese und Untersuchung zum Ausschluss weiterer kardiovaskulärer Risikofaktoren. Ein Kopfschmerztagebuch in den ersten drei Anwendungsmonaten ist sinnvoll, um zu beobachten wie betroffene Frauen auf die Hormone reagieren
Mexican Candy Vender [sic] on Military Plaza, San Antonio, Texas.
No full textMen selling Mexican candy on Military Plaza in San Antonio, Texas.Recto: [imprinted] 7870. Mexican Candy Vender [sic] on Military Plaza San Antonio, Texas. Verso: [imprinted] Published for S. Rabe, San Antonio, Texas
Evidenca dejanske rabe kmetijskih in gozdnih zemljišč
No full textEvidenca dejanske rabe kmetijskih in gozdnih zemljišč (v nadaljevanju: Evidenca dejanske rabe) je enotna državna evidenca o dejanski rabi zemljišč. Primarno je namenjena ugotavljanju dejanskega stanja rabe zemljišč kot pogoja za izvajanje ukrepov skupne kmetijske politike Evropske unije. Posredno in neposredno se podatki Evidence dejanske rabe uporabljajo tudi pri določanju dejanske rabe na parcelo v zemljiškem katastru, višine katastrskega dohodka, odškodnine za spremembo namembnosti kmetijskih zemljišč, spremembe bonitete zemljišč, upravičenosti do socialnih podpor, za statistične analize, raziskave, ipd. Podatki o gozdu v Evidenci dejanske rabe se usklajujejo s podatki iz evidenc Zavoda za gozdove Slovenije. Evidenca se vodi v grafični obliki na osnovi ortofoto (skeniran ali digitalni letalski ali satelitski posnetek) in drugih virov. V evidenci se vodijo podatki za posamezni poligon dejanske rabe. Pravna podlaga: a) Zakon o kmetijstvu (ZKme-1: http://www.pisrs.si/Pis.web/pregledPredpisa?id=ZAKO4716) in b) Pravilnik o evidenci dejanske rabe kmetijskih in gozdnih zemljišč (http://www.pisrs.si/Pis.web/pregledPredpisa?id=PRAV9267). Zajem oz. razmejitev se izvede v skladu s takrat veljavno pravno podlago (pravilnik) ter podrobnejšimi navodili za zajem dejanske rabe (interpretacijski ključ). V pravilniku je tudi e-naslov, na katerem je objavljen Šifrant in opis vrst dejanske rabe kmetijskih in gozdnih zemljišč. Aktualni pravilnik in ključ sta dostopna na http://rkg.gov.si/GERK/. Na omenjeni spletni strani so v ESRI shape formatu javno dostopni aktualni, do 1 mesec stari podatki iz evidence in arhivski podatki (stanje evidence v letih 2002, 2005, 2009, 2012, 2014, 2017). Datoteke poleg omenjenih podatkov vsebujejo tudi šifrante, metodološka pojasnila ter še nekaj drugih prikazov. Pri uporabi podatkov, predvsem pri časovni primerjavi, je potrebno upoštevati omejitve, ki izhajajo iz sprememb metodologije, ki so vezane na spremembe pravilnika in/ali interpretacijskega ključa. Podatki med leti tako niso neposredno primerljivi
Code-switching among bilingual Afrikaans-Dutch children
No full textTo describe the code-switching in the speech of pre-school, bilingual Afrikaans-Dutch children, novel language data of eight preschool children between the ages of 2;3, and 6;4 who are raised bilingually in Afrikaans and Dutch in South Africa were collected and analysed. The parent-report method was employed to collect the data, and the data collection period lasted a total of approximately two months.
The NWU HSSEC ethics number for the research is: NWU-02043-20-S
Evolution on a Microscale: Empowering Adaptation and Selection through a Microfluidic Chip
No full textIntroduction
Adaptive laboratory evolution (ALE) is a key tool to investigate fundamental questions about the processes underlying the evolution of life and how microbial populations adapt to their environments, such as the emergence of antibiotic resistance. Microfluidics have fundamentally changed the field of microbial ALE as it can mimic naturally occurring microenvironments promoting the growth of biofilms alongside planktonic cells.[1]
Goals
A microfluidic ALE chip device that features adjustable, spatially defined physico-chemical stressor gradients should be developed employing an in-flow gradient aligned parallel to the flow direction to enhance the robustness of ALE process including the efficient on-chip screening of the complete entire cell population.
Materials & Methods
The evo.S (evolution under stress) microfluidic chip was designed using CAD and fabricated from PDMS (polydimethylsiloxane) and used for the adaptation of microbial cells to stressors in a customizable stressor concentration gradient.[2]
Results
The controlled generation of different gradient profiles across the interconnected compartments leads to adaptation of Escherichia coli to the presence of antibiotics and revealed the chip’s capacity to differentiate between persistence and resistance. Importantly, this approach was effectively employed for the discovery of previously unknown mutations conferring resistance to nalidixic acid in E. coli. Recently, the chip was modified to successfully adapt the thermophilic organism Thermus thermophilus to kanamycin.
Summary
The evo.S chip enhances the occurrence of mutations, resulting in the generation of stress-resistant strains. This kind of miniaturized chip-based ALE offers crucial insights into the mechanism of antibiotic resistance and can be applied to adapt virtually any microorganism.
References
[1] Zoheir, A. E., Stolle, C., Rabe, K. S., Appl. Microbiol. Biotechnol. 2024, 108, 162.
[2] Zoheir, A. E., Späth, G. P., Niemeyer, C. M., Rabe, K. S., Small 2021, 17, 2007166
Rabe, Edward (Death, 1890-10-08)
No full textAddress: Dodsworth Ave.Age at death: 1 yrPg 119/1890/132/MW S/City/Dr. R.H. Whallon/Rabe/St. Joseph's OldOriginal record filed in drawer labeled 'QANGENHEIDER-RAPLEY'
Rabe, Lilly (Death, 1889-04-19)
No full textAddress: Blue Rock & LakemanAge at death: 17mo.Pg 43/1889/364/F W S/City/Dr. Musekamp & Rowe/Rabe/St. Joseph's OldOriginal record filed in drawer labeled 'QANGENHEIDER-RAPLEY'
Spremembe rabe tal na območju pomurske statistične regije
No full textThe paper showed land use changes in the Pomurje statistical region in the period 2000-2020. Changes are analysed in 11 categories of land use at the level of the whole region and at the level of municipalities. The directions of land use change are also analysed. Changes in arable land are shown using the extensification coefficient.V prispevku smo prikazali spremembe rabe tal na območju pomurske statistične regije v obdobju 2000-2020. Analizirane so spremembe na 11 kategorijah rabe tal na nivoju celotne regije in na nivoju občin. Prikazane so tudi smeri sprememb rabe tal. Spremembe obdelovalnih površin so prikazane s pomočjo koeficienta ekstenzifikacije
Undergraduate Medical Students "On Call" to Assist in Theatre: Analysis of the Financial Aspects and a Mixed-Method Study Exploring Their Motives forWorking
No full textBackground/Purpose Surgical patient care has grown in complexity, as hospital workload has continuously increased. We therefore established a pool of " undergraduate medical students on call" to assist in the theatre outside working hours. We aimed to recruit talented students to reduce the burden on physicians and to motivate students into entering surgery. Methods An exploratory mixed-method study was performed. In a qualitative study, guided interviews were conducted with five students about their reasons for working in the theatre and the results were used to construct an online questionnaire using EvaSys r. This was presented to 16 current and former students in a subsequent quantitative study. Furthermore, the cost of student employment was calculated and compared with physicians ' salaries. Results In 2013 and 2014, 8-9 students worked a total of 1063 and 1211 hours in the theatre, respectively. The difference in salaries between the students and surgical residents was (sic)28.37 per hour. We calculated that the annual savings were approximately (sic)60,000. When questioned on their motives during the interview, only a few students emphasised the financial aspects, whereas the majority emphasised the gain in experience. The analysis was based on comparison of the mean values (online survey) with a 4-point Likert scale (1 = high acceptance; 4 = no acceptance). We defined the motives with a mean <= 1.3 as primary. Based on this selection, gathering experience, fun/enjoyment, interest in surgery, and the change from studying were considered as distinct motives. In the interviews, students clearly pointed out that teaching and learning opportunities in the theatre were not commonly taken advantage of and that interaction with the surgeons should be improved. Conclusion Students actively chose to work as assistants in the theatre, for a variety of motives. The financial aspects were subordinate. The concept of students assisting in the theatre is favourable for both employers and students. However, the results also reveal that there is room for improvement in the implementation of the concept
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