36 research outputs found
Risultati clinici del trattamento con acido jaluronico per via intraarticolare nella gonartrosi
No full textAuthor report results of 98 patients with osteoarthritis of the knee treated with intraarticular hyaluronic acid. Treatment are prformed with one intraarticular every week, for 6 weeks. In the study are considered patients abserved and treated in 4 years serious osteoarthritis of the femour-patellar joint diagnosed by X-ray. This caused serious deficit of joint motion and considerable pain, particularly during walk. Evaluation of treatment with hyaluronic acid are made at 1, 3 and 9 months. The following parameters were evaluated: selfvaluation of pain with SVA in according with Scott-Huskisson, shwos remarkable reduction both at rest and walk at 1 month evaluation, which remains unchanged at 3 months and at 9 months evaluation, it get back as when at started. Joint range of motion evaluation was besed on joint morning stiffness, passive joint motion and even on walk ability in plain, in climb and in descent. Selfvaluation with SVA of joint morning stiffness shwos initial improvement with progressive increase up to 3 months, and then return at the initial values at 9 monthd evaluation. Passive joint motion (tested in degrees) show very good improvement at 1 and 3 months evaluation but agian it returns at the initial values at 9 months check. Walking in palin, evaluated as length of distance followed, shows progressive improvement until 3 months control. The same trend occurs in walking in clim and descent, evaluated as number of steps followed; but imprivement are keep at 9 months control. This study shows good results after treatment with intraarticular hyaluronic acid in osteoarthritis of the knee
Correction to: Bias and potential misinterpretations in the analysis of insects collected from human remains of archaeological interest (Archaeological and Anthropological Sciences, (2021), 13, 11, (201), 10.1007/s12520-021-01458-2)
No full textThe author regret that their names in the original article was inverted. Their correct names are listed in this erratum article. The original article has been corrected
A methodology for monitoring and modeling of high altitude Alpine catchments
No full textHydrological monitoring and modeling of high altitude Alpine catchments is of paramount importance. This is difficult, however, given the complex logistics of field campaigns and the need for long-term data. Here, we present a method for long term monitoring of high altitude catchments, which we tested within the Alps of Italy. This includes i) extensive gathering of climate data and hydrological fluxes, ii) high altitude field campaigns, and iii) robust physically based glacio-hydrological modeling, providing full account of ice flow, ice and snow ablation, and stream flows. We present an application of this method based on six years (2009â2014) of field monitoring in the Dosdà ̈ catchment, in the Italian Alps (17 km2, average altitude 2858 masl, outlet 2133 masl), nesting 1.90 km2 of glaciers. We demonstrate that i) high altitude Alpine catchments can be monitored in spite of geographical complexity, and ii) a data based approach delivers accurate stream flow estimates and improves our knowledge of flow components in the high altitudes. We then provide some estimates of the recent glaciersâ dynamics, and water resources from this high-altitude catchment, paradigmatic of the recent cryospheric evolution in the Alps of Italy. We estimated an average ice mass loss nearby â1.76E8 m3yrâ1, i.e. â20% of the ice mass in 2009, possibly pointing to accelerated glaciersâ down wasting. Instream discharges increased (+0.12 m3sâ1yâ1); however, this requires further monitoring. We then benchmark our findings against recent studies in the Alps, and other glacierized areas worldwide, displaying similarities in present glaciersâ dynamics. We suggest that our robust, yet flexible approach can be used for glacio-hydrological investigation in Alpine (and generally mountain) rivers, and for conjectures of potential future hydrological cycle under climate scenarios
Cancer stem cell and therapeutic resistance in breast cancer : targeting breast cancer stem cell by inhibition of DNA replication response
No full textLes tumeurs mammaires sont connues pour présenter une grande hétérogénéité intratumorale qui contribue à l’échec thérapeutique et à la progression de la maladie. L’origine de dette hétérogénéité s’explique principalement par l’organisation hiérarchique des tissus tumoraux où plusieurs sous-populations de cellules souches de cancer du sein (bCSC) sont capables de s’auto-renouveler et de maintenir l’architecture oligoclonale de la tumeur. Dans la mesure où les bCSC stimulent la croissance tumorale, résistent aux thérapies conventionnelles et initient le développement des métastases, il est indispensable de développer des thérapies spécifiques ciblant ces cellules. L’élaboration d’une telle stratégie nécessite la compréhension des propriétés moléculaires intrinsèques des bCSC. Pour mieux comprendre leur biologie, nous avons isolé les bCSC de différentes xénogreffes dérivées de tumeurs de patientes et établit leurs profil d’expression génique. Nous avons identifié un programme transcriptionnel pouvant être impliqué dans la réduction du stress réplicatif (SR) des bCSC . Nous avons montré que comparé aux non-bCSC, les bCSC présentent une sur-activation de la recombinaison homologue qui leur permet de réduire leur niveau de SR. Nous avons ensuite montré en réalisant un essai clinique que l’inhibition de cette voie permet de les sensibiliser à des agents génotoxique. Ces travaux identifient le SR comme le talon d’Achille des bCSC et mettent en évidence la recombinaison homologue comme cible potentielle pour sensibiliser les BCSC aux thérapies conventionnelles.Breast tumors are known to present a major intratumoral heterogeneity that contributes to therapy failure and disease progression. The origin of this cellular heterogeneity is mainly explained by a hierarchical organization of tumor tissues where several subpopulations of self-renewing breast cancer stem cells (bCSCs) sustain the long-term oligoclonal maintenance of the neoplasm. bCSCs drive tumor growth, resist to conventional therapies and initiate metastasis development. Thus, developing bCSC-targeting therapies is becoming a major challenge requiring the understanding of the unique molecular circuitry of bCSC as compared to non-bCSC. To better understand the biology of these cells, we isolated bCSCs from different patient–derived xenografts (PDXs), derived fom breast tumors, and established their gene expression profiles. We identified a bCSC core transcriptional program that may be implicated in the reduction of the replicative stress in CSC: overexpression of genes implicated in dNTP metabolism and homologous recombination (HR). Our results show that HR plays a major role in SR regulation of bCSC and that bCSC are more resistant to RS than non-bCSC, We realized a preclinical assay in PDX and showed that HR inhibition prevent bCSC expansion Cisplatin-induced, suggesting a sensitization of the bCSC to the chemotherapy. Our results identify replication stress as the Achilles’ heel of bCSC and highlights HR as potential targets for anti-bCSC therapy
Leggere il tempo. Conversazione sull’architettura sensibile di Armando Ruinelli
No full textArmando Ruinelli’s forty-year architectural experience, as documented in the recent publication Leggere il tempo, is characterised by its sensitivity and attention to context. Devoid of excess and extravagance, his work establishes a polite dialogue with its surroundings, reflecting the discreet personality of the author. At the core of Ruinelli’s practice lies a profound ethical consideration, extending beyond the design phase to encompass the entire spectrum of operational intricacies. His perspective on time translates into an acceptance of material aging, emphasising the importance of allowing buildings to follow their natural course. Rooted in context, his architecture seeks not only continuity but harmonious integration within the Alpine landscapes they inhabit. In dialogue with the interviewer, Ruinelli emphasises his preference for artisanal work, highlighting the significance of precision in execution and the centrality of humans over materials. His poetic exploration is manifested in creating atmospheres and carefully balancing the dynamic components of a project. Reflecting on the role of the architect, he envisions them as craftsmen endowed with both technical acumen and creative vision. Finally, Ruinelli shares a meaningful project – the fountains in the Soglio cemetery – a creation laden with delicacy and symbolism that underscores the spiritual depth of his work
Economic growth and regional income inequality in Brazil
No full textThis paper analyses the evolution of regional inequality in Brazil in the period 1939-1995. Based on a data set organized by the author, indicators of per capita income dispersion among states and regions are presented and their evolution over time is analyzed. The correlation between the regional initial level of per capita income and its growth is considered, testing for Beta convergence. The speed of convergence is calculated in two different forms, the neoclassical model and the coefficient of variation, the later allowing for the analysis of oscillations in inequality over time and its relationship to national economic growth rates. The Kuznetz hypothesis, relating regional income inequality and level of development, is tested. The results indicate the presence of signs of regional income convergence in Brazil, but with important oscillations in the evolution of inequality over time as well as across regions within the country. The association of regional inequality with national income growth produced interesting results, indicating a promising line for future research.
Love, Anankasticity, and Human Rights: The Perspective of a Petrazyckian continental legal realism
No full textIn this essay the author analyzes the social phenomenon of human rights from the perspective of Leon Petrażycki’s Continental legal realism (Petrażyckianism). After shortly presenting this approach in § 1, in § 2, the author argues that, from this perspective, that of human rights is to be regarded as a naïve concept – akin to the concept of vegetable. As a naïve concept, for its investigation the concept of human rights requires stipulative concepts. To this goal, in § 3, the author proposes the stipulative concept of a humane jural conviction. In § 4, by combining Petrażyckianism with the ideas of Gianluigi Palombella, on the one hand, and those developed within the Contean school (in particular, by Amedeo G. Conte and Giampaolo Azzoni), on the other, further stipulative concepts are proposed, namely, those (a) of a fundamental substantive-jural anankastic normative-factical conviction and (b) of a fundamental substantive-jural paranankastic normative-factical conviction. By the former term (a), the author understands an individual’s conviction concerning certain jural norms that it must be possible (or impossible) to extract from a normative fact for that normative fact to be experienced as binding. By the latter term (b), the author understands an individual’s conviction concerning the jural norms that it must be possible (or impossible) to extract from a binding normative fact1 for a certain authority (e.g., a constitutional body) not to be regarded as entitled (or as obliged) to enact a normative fact2 aimed at removing the psychosocial effects brought about by that normative fact1. In the last section, the author discusses the issue of a possible “foundation” of human rights, from the perspective of Petrażyckianism. In this section, also the connection of anankasticity and paranankasticity to the principle of proportionality is discussed
Towards enhanced second-generation n-butanol production from sugarcane
No full textNowadays, the biotechnology industry is facing the challenge of producing suitable equivalents for petroleum-based products from renewable resources in a sustainable and economically feasible way. Finding cleaner alternatives for gasoline, fuels, and chemicals, has been the subject of research worldwide, whether for economic, geopolitical, or environmental reasons. Among these alternatives, liquid fuels derived from biomass stand out for their eco-friendly production....BT/Environmental Biotechnolog
Location and regional income disparity dynamics: The Brazilian case
No full textIn this note we provide evidence on the importance of location for the growth of per capita income of Brazilian states over the period 1985-2001. The study presents strong evidence of spatial dependence, and that regional inequality reduction occurred simultaneously with increasing spatial autocorrelation. The analysis of local indicators of spatial association confirmed that conclusion, showing the existence of two geographical clusters, one of low income states in the Northeast and North regions, and another of rich states in the Southeast and South regions. The low value for the convergence coefficient, in conjunction with the strong influence of shocks in the residuals, indicate the existence of a very sensible dynamic pattern of convergence across Brazilian states, which helps explaining the well documented persistence in regional income disparities in Brazil. After conditioning on other important variables that could affect growth, however, spatial dependence disappears. We have thus identified two potential channels through which the strong spatial dependence in the process of convergence of per capita income of Brazilian states occurs. Copyright (c) 2006 the author(s). Journal compilation (c) 2006 RSAI.
A participação dos jovens nas agroindústrias familiares do litoral sul catarinense e as implicações no processo sucessório
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em AgroecossistemasA agricultura familiar é responsável por grande parte do abastecimento alimentar, pela diversificação das atividades econômicas e pela manutenção do tecido social e cultural nos espaços rurais. Apesar de sua relevância na produção agrícola e sua capacidade de interação com outras atividades econômicas e sociais, diversos estudos apontam a crescente migração dos jovens do meio rural o que têm implicado na ausência de sucessores nas unidades familiares. Entretanto, as agroindústrias familiares vêm surgindo como uma importante estratégia de reprodução social permitindo a permanência dos agricultores e de suas famílias no campo, pois acaba absorvendo mão-de-obra familiar como a das mulheres e jovens. Desse modo, o presente trabalho teve como objetivo analisar a participação dos jovens rurais em todas as atividades realizadas nas agroindústrias, desde a produção da matéria-prima, beneficiamento, comercialização dos produtos e administração do empreendimento; e o seu efeito gerado na permanência e sucessão da unidade familiar. Para isso, foi verificado o grau de satisfação dos jovens com as atividades desempenhadas nas agroindústrias, a autonomia, remuneração pelo serviço prestado e o envolvimento na tomada de decisão. O trabalho foi realizado no Litoral Sul Catarinense em sete municípios: Grão Pará, Imaruí, São Ludgero, São Martinho, Santa Rosa de Lima, Treze de Maio e Tubarão. A pesquisa foi fundamentada em métodos qualitativos, adotando como estratégia os casos múltiplos (agroindústrias e municípios). A população deste estudo é formada por jovens com faixa etária entre 15 e 24 anos, de ambos os sexos e que trabalham nas agroindústrias familiares. Para coleta de dados foram realizadas entrevistas semi-estruturadas com os jovens e com os pais dos jovens envolvidos com agroindústrias familiares de diferentes ramos. De acordo com os dados obtidos, a permanência dos jovens e posterior sucessão da unidade familiar depende da intensidade da sua participação nas atividades desenvolvidas nas agroindústrias e de fatores condicionantes como satisfação, motivação, autonomia, afinidade e remuneração pelo serviço prestado. Portanto, constatou-se diferenças entre gênero e geração em relação à permanência e sucessão dos jovens nas unidades familiares. Geralmente, jovens entre 15-19 anos estavam indecisos ou não pretendiam permanecer na propriedade buscando outros projetos de vida. Ao contrário dos jovens entre 20-24 anos que pretendiam permanecer e suceder seus pais
