90 research outputs found
sj-pdf-1-imr-10.1177_03000605231174998 - Supplemental material for Coronary artery perforation successfully treated with a second drug-eluting stent
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605231174998 for Coronary artery perforation successfully treated with a second drug-eluting stent by Matej Strycek, Lukas Jaworski, Rostislav Polasek and Pavol Tomasov in Journal of International Medical Research</p
Malignant mesothelioma associated with localized myocardial fibrosis: a case report
No full textAbstract Left ventricular dysfunction is a common reason for patients’ referral to cardiology departments for examination. Cardiac involvement is one of the possible yet rare presentations of malignant mesothelioma. We present a case of a patient in whom a routine cardiac examination and imaging revealed malignant mesothelioma. We discuss a possible association between a malignant tumor and myocardial scarring and how the oncologic treatment is influenced by concomitant heart failure. This article aims to raise awareness of the importance of multidisciplinary cooperation and thinking beyond the daily routine of our specialty to ensure the quality care of our patients. It also forced us to think about the possible causes of the association between malignant mesothelioma and myocardial fibrosis
Refractory cardiogenic shock in hypertrophic cardiomyopathy complicated by apical ballooning: A case report
No full textHypertrophic cardiomyopathy can be accompanied by dynamic obstruction in the left ventricular outflow tract and acute apical ballooning, which are among the very rare causes of cardiogenic shock. This condition requires a specific treatment approach that in many ways differs from the treatment of other causes of cardiogenic shock. We present a case and our treatment strategy (including extracorporeal life support) for refractory cardiogenic shock in a patient with previously undiagnosed hypertrophic cardiomyopathy
Personality and Work of Jan Nepomuk Polasek (1873-1956)
No full textThis dissertation thesis focuses on the person and work of Jan Nepomuk Polášek (1873-1956), a distinguished regional composer and music teacher who spent a significant part of his life in Valašské Meziříčí. Throughout his life, Polášek devoted himself to creative work, which was, to a varying degree, inspired by the Moravian Wallachian folk culture. The thesis outlines the important phases of Polášek's life including his childhood and school days, first contact with music teaching, his studies at the Brno Organ School, and, last but not least, his relationship with Leoš Janáček. The Biographical part of the thesis ends with a subchapter devoted to Polášek's work in Valašské Meziříčí until his death in 1956. Polášek's body of work includes his compositions, music-related organisational activities, music teaching, publishing and folk song collecting. The aforementioned activities are presented and analysed in the remaining chapters of this dissertation thesis. The final chapter analyses selected instrumental, vocal-instrumental and vocal compositions of Polášek's, based on which it illustrates the key elements of his creative work. The thesis presents some entirely new findings regarding the life and work of Jan Nepomuk Polášek that are founded on many information sources the author obtained. Key..
Personality and Work of Jan Nepomuk Polasek (1873-1956)
No full textThis dissertation thesis focuses on the person and work of Jan Nepomuk Polášek (1873-1956), a distinguished regional composer and music teacher who spent a significant part of his life in Valašské Meziříčí. Throughout his life, Polášek devoted himself to creative work, which was, to a varying degree, inspired by the Moravian Wallachian folk culture. The thesis outlines the important phases of Polášek's life including his childhood and school days, first contact with music teaching, his studies at the Brno Organ School, and, last but not least, his relationship with Leoš Janáček. The Biographical part of the thesis ends with a subchapter devoted to Polášek's work in Valašské Meziříčí until his death in 1956. Polášek's body of work includes his compositions, music-related organisational activities, music teaching, publishing and folk song collecting. The aforementioned activities are presented and analysed in the remaining chapters of this dissertation thesis. The final chapter analyses selected instrumental, vocal-instrumental and vocal compositions of Polášek's, based on which it illustrates the key elements of his creative work. The thesis presents some entirely new findings regarding the life and work of Jan Nepomuk Polášek that are founded on many information sources the author obtained. Key...Disertační práce se zabývá osobností a dílem J. N. Poláška (1873-1956), významného regionální hudebního skladatele a pedagoga, který podstatnou část svého života prožil ve Valašském Meziříčí. Polášek se v průběhu svého života věnoval tvůrčí činnosti, do které v různé míře prostupovaly prvky valašské lidové kultury. Práce mapuje důležité životní etapy Poláškova života, zmiňuje dětská a školní léta, první kontakty s hudebním vzděláváním, studia na varhanické škole v Brně, přičemž neopomíjí ani setkání s Leošem Janáčkem. Biografická část je zakončena podkapitolou, která se věnuje Poláškovu působení ve Valašském Meziříčí až do jeho smrti v roce 1956. Stěžejní dílo Jana Nepomuka Poláška představuje kompoziční tvorba a jeho hudebně-organizační, pedagogická, publikační a sběratelská činnost. Uvedenými aktivitami a jejich analýzou se zabývá významná část disertační práce. V závěrečné části práce se nachází analýza vybraných Poláškových instrumentálních, vokálně-instrumentálních a vokálních skladeb, na jejichž základě jsou ukázány charakteristické prvky, které se v Poláškově tvorbě vyskytují. V předkládaném textu uvádíme zcela nová zjištění týkající se života a tvůrčích aktivit Jana Nepomuka Poláška, která se opírají o značné množství získaných pramenů. Klíčová slova: Jan Nepomuk Polášek, Valašsko, Valašské...Katedra hudební výchovyFaculty of EducationPedagogická fakult
Software Model Creation with Multidimensional UML
No full textPart 11: Social Impact of EIS and VisualizationInternational audienceThe aim of the paper is to present the advantages of the Use Cases transformation to the object layers and their visualization in 3D space to reduce complexity. Our work moves selected UML diagram from two-dimensional to multidimensional space for better visualization and readability of the structure or behaviour.Our general scope is to exploit layers for particular components or modules, time and author versions, particular object types (GUI, Business services, DB services, abstract domain classes, role and scenario classes), patterns and anti-patterns in the structure, aspects in the particular layers for solving crosscutting concerns and anti-patterns, alternative and parallel scenarios, pessimistic, optimistic and daily use scenarios.We successfully apply force directed algorithm to create more convenient automated class diagrams layout. In addition to this algorithm, we introduced semantics by adding weight factor in force calculation process
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Author Correction: A global analysis of terrestrial plant litter dynamics in non-perennial waterways
No full text© 2018 The Author(s) In the version of this Article originally published, the affiliation for M. I. Arce was incorrect; it should have been:5Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Berlin, Germany. This has now been corrected in the online versions of the Article
Local electrogram delay recorded from left ventricular lead at implant predicts response to cardiac resynchronization therapy: Retrospective study with 1 year follow up
No full textAbstract Background Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance of left ventricular electrode local electrogram delay from the beginning of QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in the late activated regions is associated with the higher probability of positive CRT response. Methods We conducted a retrospective, single–centre analysis of 161 consecutive patients with heart failure and LBBB or nonspecific intraventricular conduction delay (IVCD) treated with CRT. We routinely intend to implant the LV lead in a region with long QLV. Clinical response to CRT, left ventricular (LV) reverse remodelling (i.e. decrease in LV end-systolic diameter - LVESD ≥10%) and reduction in plasma level of NT-proBNP >30% at 12-month post-implant were the study endpoints. We analyzed association between pre-implant variables and the study endpoints. Results Clinical CRT response rate reached 58%, 84% and 92% in the lowest (≤105 ms), middle (106-130 ms) and the highest (>130 ms) QLV tertile (p Conclusion LV lead position assessed by duration of the QLV interval was found the strongest independent predictor of beneficial clinical response to CRT.</p
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
No full textElevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets
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