1,079 research outputs found
Dr Giacomo Rossitto interviews Professor Rhian Touyz, on the translational applications of vascular smooth muscle cell biology in cardiovascular disease
No full textProfessor Touyz discusses her passion for translational research and the amazing plasticity of the vascular smooth muscle cell, recently covered in the Cardiovascular Research Spotlight Issues ‘Novel concepts for the role of smooth muscle cells in vascular disease’
Letter to the Editor From Paolo Rossi and Rossitto: "Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism"
No full textMechanisms of sodium-mediated injury in cardiovascular disease: old play, new scripts
No full textThere is a strong association between salt intake and cardiovascular diseases, particularly hypertension, on the population level. The mechanisms that explain this association remain incompletely understood and appear to extend beyond blood pressure. In this review we describe some of the "novel" roles of Na+ in cardiovascular health and disease: energetic implications of sodium handling in the kidneys; local accumulation in tissue; fluid dynamics and the role of the microvasculature, with particular focus on the lymphatic system. We describe the interplay between these factors that involves body composition, metabolic signatures, inflammation and composition of the extracellular and intracellular milieus
Of snails, earthworms, and men: insights into strategies to preserve water
No full textNo abstract available
Does excess tissue sodium storage regulate blood pressure?
No full textPurpose of Review:
The regulation of blood pressure is conventionally conceptualised into the product of “circulating blood volume” and “vasoconstriction components”. Over the last few years, however, demonstration of tissue sodium storage challenged this dichotomous view.
Recent Findings:
We review the available evidence pertaining to this phenomenon and the early association made with blood pressure; we discuss open questions regarding its originally proposed hypertonic nature, recently challenged by the suggestion of a systemic, isotonic, water paralleled accumulation that mirrors absolute or relative extracellular volume expansion; we present the established and speculate on the putative implications of this extravascular sodium excess, in either volume-associated or -independent form, on blood pressure regulation; finally, we highlight the prevalence of high tissue sodium in cardiovascular, metabolic and inflammatory conditions other than hypertension.
Summary:
We conclude on approaches to reduce sodium excess and on the potential of emerging imaging technologies in hypertension and other conditions
Aldosterone and cardiovascular damage: a new lesson from an old study
No full textNo abstract available
A tradução como experiência e reflexão no Epistolario e no Zibaldone di Pensieri de Giacomo Leopardi
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2012Esta dissertação analisa as reflexões sobre tradução de Giacomo Leopardi (1798-1837) presentes no Epistolario (1807-1837) e no Zibaldone di Pensieri (1817-1832), no período de 1817 a 1832 por meio de um estudo comparativo. O primeiro capítulo traz uma breve contextualização do cenário histórico-literário do século XIX, que evidencia os acontecimentos que geraram o intenso debate entre Classicistas e Românticos, e contempla o percurso do autor de Recanati nessa discussão. O segundo capítulo aborda o Epistolario e o Zibaldone, à luz dos gêneros literários, e evidencia a importância deles no conjunto da obra do autor de Recanati. O terceiro capítulo apresenta uma análise dos principais aspectos sobre tradução discutidos pelo autor italiano, dos quais destacam-se: a tradução como exercício para se tornar um importante escritor; a importância da retradução dos Clássicos; a questão da (in)intraduzibilidade; a fidelidade ao original e a questão da língua no que diz respeito ao estilo, ao caráter e à adaptabilidade na tradução.Abstract : This dissertation analyzes the reflections on translation by Giacomo Leopardi (1798-1837) found in Epistolario (1807-1837) and Zibaldone di Pensieri (1817-1832), within the period from 1817 to 1832 through a comparative study. The first chapter presents a brief contextualization of the 19th century historical and literary scenery, that highlight the events which generated the intense debate between Classicists and Romantics, and it thinks over the path of Recanati#s author in this discussion. The second chapter approaches Epistolario and Zibaldone, under the light of literary genres, and highlight their importance within the entire work of Recanati#s author. The third chapter presents an analysis of the main aspects on translation discussed by the Italian author, which include: the translation as an exercise to become a good writer, the importance of retranslation of the Classics, the issue of (in)translatability; fidelity and the question of the original language with regard to style, the character and adaptability in translation
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