1,721,043 research outputs found
WT1 protein is a transcriptional activator of the antiapoptotic bag3 gene. Turco M=Corresponding Author
No full textThe transcription factor WT1 has an oncogenic role in a variety of tumors from different origins including acute lymphoblastic and myeloblastic leukemias. Here we demonstrated that WT1 is able to bind bag3 promoter and to induce bag3 transcription in myeloid leukemia. We also demonstrated that the induction of BAG3 protein is partially responsible for the anti-apoptotic activity of WT1 protein
Identification of a Btk-BAG3 complex induced by oxidative stress. Turco MC: Corresponding Author
No full textAnti-BAG3 antibodies in combination with inhibitors of immune check-point for therapeutic use
No full textHumanized anti-bag3 antibodies
No full textThe present invention provides for a humanized anti-BAG3 antibody or a fragment thereof, pharmaceutical compositions comprising said antibody and its use as a medicament, in particular for use in the treatment of pancreatic tumours or other pathologies of an immune, inflammatory, neoplastic, cardiovascular and/or degenerative nature
Load-time failure envelopes for suction caissons under sustained vertical loading
No full textSuction caissons are established as a reliable anchoring system to moor a range of offshore floating facilities. Under sustained loads, generally characterized by long durations, the caisson holding capacity against uplift loading, that relies on suction pressures induced within and at the base of the soil plug, is expected to reduce over time, due to the equalization of pore water pressures. The scarcity of studies addressing this sustained loading problem has motivated this study, in which the response of suction caissons in soft clay subjected to sustained vertical uplift loads is investigated through finite element simulations and centrifuge model tests. Results are presented in the form of failure envelopes in the load-time plane, correlating, for each failure mechanism detected, the load level to the corresponding holding time. The findings of this study are consid-ered useful for concept design purposes, when sustained loads govern the caisson design
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
BAG3 protein is induced during cardiomyoblast differentiation and modulates myogenin expression.
No full text
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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