1,720,987 research outputs found
Cervical mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature.
No full textBMC Cancer. 2011 Jun 11;11:11:236. doi: 10.1186/1471-2407-11-236.
Cervical Mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature.
Patrelli TS, Gizzo S, Di Gangi S, Guidi G, Rondinelli M, Nardelli GB.
SourceDepartment of Gynecological and Human Reproduction Sciences, University of Padua, via Giustiniani 3, 35128 Padua, Italy.
Abstract
BACKGROUND: Uterine sarcomas are relatively rare tumors that account for approximately 1-3% of female genital tract malignancies and between 4-9% of uterine cancers. Less than 8% of all cases are Mullerian adenosarcoma, a distinctive uterine neoplasm characterized by a benign, but occasionally atypical, epithelial and a malignant, usually low-grade, stromal component, both of which should be integral and neoplastic constituents of the tumor. Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very aggressive variant, associated with post-operative recurrence, metastases, even when diagnosed in early stage.
CASE PRESENTATION: We present a fourth MASO case derived from uterine cervix in a 72-year-old woman with metrorrhagia and a polypoid mass protruding through the cervical ostium. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, systematic pelvic lymph node dissection, omental biopsy and appendectomy were performed. Surgery treatment was associated with adjuvant whole-pelvis radiation (45 Gy) and adjuvant chemotherapy (cisplatin/ifosfamide). After nine months of follow up, the patient was free of tumor.
CONCLUSIONS: The rarity of MASO of the cervix involves a management difficult. Most authors recommend total abdominal hysterectomy, usually accompanied by bilateral salpingo-oophorectomy. There is no common agreement on staging by lymphadenectomy during primary surgery and adjuvant chemo-radio therap
Wolfram syndrome 2: a novel CISD2 mutation identified in Italian siblings.
No full textWolfram syndrome, also referred to as Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness (DIDMOAD), is a rare autosomal recessive neurodegenerative disorder. Affected individuals had childhood insulin-requiring non-autoimmune diabetes mellitus and bilateral progressive optic atrophy, usually occurring during the first and second decade of life, respectively. Neurological clinical features include sensorineural hearing loss (slowly progressive high-frequency deafness), ataxia, dementia and psychiatric disease; olfactory defects are also frequent; central apnoea is a common cause of mortality. Further, neuronal degeneration might be involved in gastrointestinal dysmotility and a number of urinary tract dysfunctions (hydroureter, detrusor-sphincter dyssynergia, detrusor overactivity, urinary tract atony)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Phosphate double cladding optical fibers for short cavity pulsed lasers
No full textPhosphate glasses are interesting materials for the fabrication of double cladding optical fibers suitable for pulsed lasers in the near infrared wavelength region. The fabrication of Nd, Yb and Yb/Er doped phosphate glasses will be reported together with the characterization of their thermal and optical properties. Suitable passive glasses for 1st and 2nd cladding were manufactured with the aim of obtaining the designed numerical apertures while maintaining well-matched physical properties for stress-free configurations. Preform fabrication by means of rotational casting will be discussed and compared to traditional rod in tube technique in particular regarding the interfaces between core and 1st cladding and between 1st and 2nd cladding. Double cladding optical fibers will be presented and characterized in terms of attenuation loss via cutback method. The demonstration of laser emission will follow by employing fiber pigtailed laser diodes for the excitation of the rare earth ion
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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