1,721,031 research outputs found
PREDICTION AND ANALYSIS OF IDIOTYPE-ANTI-IDIOTYPE ANTIBODY COMPLEXES ASSOCIATED TO CELIAC DISEASE
No full textCalcium Binding model peptides : a spectrosopic study
No full textMetal ions play a variety of functions in proteins, spanning from the enhancement of structural stability in a conformation required for biological functions to the assistance in enzymatic processes.[1] An increasing attention has been paid to the study of mechanism of action of metallo-proteins as well as to the definition of their structural features. The use of low molecular weight 'model compounds' is a widely used approach to investigate metallo-protein properties, especially when structural details are not available or not yet unambiguous. In particular bicyclic peptides are known to be interesting models for the naturally occurring metal binding peptides and also to be able to mimic the three-dimensional structure of protein sites better than linear or monocyclic analogs. In our research group, bicyclic peptide models able to co-ordinate metal ions were designed and structurally characterized. In one of our studies we examined, by CD and NMR spectroscopy, a bicyclic undecapeptide designed to mimic structure and calcium binding properties of Calmodulin (CaM) site I.[2] The average model from RMD calculations exhibit good analogies with the natural site I. The model system, when compared with the reference system (Asp20-Glu31 segment in CaM), shows similar dimensions and an effective superimposition of the respective sequence segments. The remaining segments of the model peptide exhibit a bending that is intermediate between that of the free and Ca2+-coordinate site I. We also studied the conformation and calcium binding properties of a bicyclic peptide BCP2[3] which does not strictly reproduce any natural system. Indeed BCP2 belongs to a series of synthetic peptides designed to study, in a systematic way, the structure requirements for calcium binding ability. The spectroscopic characterization, via CD, NMR and RMD, shows that BCP2 is strikingly respondent to the design expectations. Here our results on these model peptide systems, which are able to co-ordinate calcium ion, will be discussed
COCOMAPS: a web application to analyze and visualize contacts at the interface of biomolecular complexes
No full textAbstract
Summary: Herein we present COCOMAPS, a novel tool for analyzing, visualizing and comparing the interface in protein–protein and protein–nucleic acids complexes. COCOMAPS combines traditional analyses and 3D visualization of the interface with the effectiveness of intermolecular contact maps.
Availability: COCOMAPS is accessible as a public web tool at http://www.molnac.unisa.it/BioTools/cocomaps
Contact: [email protected]; [email protected]</jats:p
Mitochondrial tRNA base substitutions: investigation of the molecular basis of respiratory defects
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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