1,721,160 research outputs found
Selenium Chemisorption Makes Iron Surfaces Slippery
No full textIn the effort to reduce the energy consumption due to friction, finding new effective lubricants is of primary importance. Here we suggest selenium as a possible element for a highly effective lubricant on iron/iron interfaces by means of density functional theory. The adsorption properties of Se on the most stable iron surface are studied and the metal–adsorbate interaction is characterized. The adsorption reveals that selenium behaves similarly to sulfur and phosphorus, two key elements for high-pressure, anti-wear lubricant additives. The tribological properties of the Fe–Se/Se–Fe interface and the electronic modifications induced by the additive are then investigated and compared with Fe–P/P–Fe and Fe–S/S–Fe interfaces. The charge rearrangement at the interface and the density of states reveal the formation of strong covalent interactions inside the adsorbed layer of selenium atoms that weaken the metal–metal interaction. The calculated work of adhesion and ideal interfacial shear strength show that, with respect to P and S, Se possesses superior lubricating properties
Monitoring water and oxygen splitting at graphene edges and folds: Insights into the lubricity of graphitic materials
Full text linkThe functionality of graphene as lubricant material is affected by extrinsic factors, such as the film thickness and the environmental conditions. Graphite lubricating capability depends as well on air humidity. To accurately describe the tribochemistry mechanisms underlying these behaviours we adopt a Quantum Mechanics/Molecular Mechanics approach. We show that reactive edges are able to cause a huge friction increase, which is quantified for graphene flakes between sliding diamond surfaces. Moreover, folds spontaneously formed in single layer graphene under tribological conditions are shown to be highly reactive due to carbon re-hybridization. This observation offers a new hint for interpreting the dependence of graphene friction on the number of layers. Both water and oxygen molecules are found to be effective in quenching the reactivity of defects by dissociative chemisorption. However, peculiar mechanisms of water molecules makes humidity more effective than oxygen for enabling the lubricity of graphitic media. They include collective processes as Grotthus-like proton diffusion enhanced by confinement, and the strong change in hydrophilic character of the passivated media. This comprehensive study sheds a new light on debated issues of graphene and graphite tribology, and highlights the potentiality of these materials for metal-free catalysis, e.g., for H production by water splitting
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
BDNF induces BDNF and TrkB mRNA dendritic targeting through a PI-3 kinase-dependent mechanism
No full textBrain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway
No full textThis study aims to understand the mechanisms of dendritic targeting of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) mRNAs. We show that brief depolarizations are sufficient to induce accumulation of BDNF and TrkB mRNAs in dendrites of hippocampal neurons. Endogenous BDNF, secreted during the KCl stimulation, contributes significantly to the dendritic accumulation of BDNF-TrkB mRNAs. In the absence of depolarization, 1 min pulses of exogenous BDNF are sufficient to induce dendritic accumulation of BDNF-TrkB mRNAs. After binding to TrkB, BDNF exerts this action by activating a PI-3 kinase-dependent pathway. The accumulation of dendritic mRNA by BDNF is not mediated by BDNF-induced neurotransmitter release. Because most hippocampal neurons coexpress BDNF and TrkB receptors, these results show that the subcellular distribution of BDNF-TrkB mRNAs is under the control of an autocrine-paracrine BDNF-TrkB-dependent loop
Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons
No full textThe mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of their dendritic mRNA localization. In the dendrites the labeling covers on average the proximal 30% of the total dendritic length. On high potassium depolarization, the labeling of BDNF and TrkB mRNA extends on average to 68% of the dendritic length. This increase does not depend on new RNA synthesis, is inhibited by the Na+ channel blocker tetrodotoxin, and involves the activation of glutamate receptors. Extracellular Ca2+, partly flowing through L-type Ca2+ channels, is absolutely required for this process to occur. At the protein level, a brief stimulation of hippocampal neurons with 10 mM KCl leads to a marked increase of BDNF and TrkB immunofluorescence density in the distal portion of dendrites, which also occurs, even if at lower levels, when transport is inhibited by nocodazole. The protein synthesis inhibitor cycloheximide abolishes this increase. The activity-dependent modulation of mRNA targeting and protein accumulation in the dendrites may provide a mechanism for achieving a selective local regulation of the activity of neurotrophins and their receptors, close to their sites of action
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