1,721,146 research outputs found
The role of genomic instabilities in affecting treatment responses of colorectal cancer
No full textColorectal cancer is one of the most common tumors worldwide. The knowledge gained on its biology and molecular changes is helping us to choose the best chemotherapeutic treatment. Two different pathways, i.e. the chromosomal and microsatellite instabilities, give the same result but with totally different biological behaviors. In fact, the response to treatment with 5-FU or platinum compounds is dramatically different in both settings. In the future, the use of these compounds should require molecular testing of the specimen prior to treatment. Copyright 2002 S. Karger AG, Base
Author Correction: Chemoprevention of Colorectal Cancer in High-Risk Patients: from Molecular Targets to Clinical Trials (Curr Colorectal Cancer Rep, (2017), 13, (192-204), 10.1007/s11888-017-0364-7)
No full textIn the original version of this article, which published in Current Colorectal Cancer Reports, Volume 13, Issue 3, June 2017, the references in both Tables 1 and 2 were captured incorrectly. The tables provided are now correct
Digestive diseases: Big burden, low funding? Results of the new United European Gastroenterology White Book on digestive diseases
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The changing approach for identifying hereditary colorectal cancer syndromes
No full textData based on next-generation sequencing (NGS) of colorectal cancers (CRC) clearly show that up to 10% of all cases harbour pathogenic variants. Thus, NGS performed for all patients with CRC under the age of 50 could be a cost-effective strategy, leading to a personalized approach to patients and family members
Horizon Europe, the new programme for research & innovation: Which opportunities for GI research in the years to come?
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Molecular Pathways of Colorectal Cancer Development: Mechanisms of Action and Evolution of Main Systemic Therapy Compunds
No full textBackground: Colorectal cancer is known as one of the “big killers” in oncology given its burden in terms on morbidity and mortality. Since the second half of the last century, similarly to what happened for other solid tumors, a large series of cytotoxic molecules have been developed and tested to treat this disease. Summary: Following new discoveries in terms of colorectal cancer pathogenesis and specific pathways involved such as angiogenesis, a new series of drugs have been developed: targeted therapies. Key Messages: In this review, we will briefly describe colorectal cancer molecular biology and its main pathways in order to retrace the main stages of oncological treatment development for colorectal cancer from the first available treatments to novel approaches to the disease
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