1,721,008 research outputs found
A symple enzymatic procedure for radioimmunochemical quantitation of large molecular forms of gastrin and cholecystokinin
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Intraduodenal bile salts exert negative feedback control on gallbladder emptying in the fasting state without affecting cholecystokinin release or intestinal motility
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Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor deficient mice.
No full textSevere impairment of postprandial cholecystokinin release and gallbladder emptying and high risk of gallstone formation in acromegalic patients during Sandostatin LAR
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Effecy of growth hormone deficiency and recombinant growth hormone therapy on postprandial gallbladder motility and cholecystokinin release
No full textIn addition to cholecystokinin, other hormones have been suggested to be involved in regulation of postprandial gallbladder contraction. We aimed to evaluate effects of growth hormone (GH) on gallbladder contractility and cholecystokinin release. Gallbladder and gastric emptying (by ultrasound) and cholecystokinin release were determined before and after 6 months of recombinant human GH (rhGH) therapy in 12 patients with GH deficiency, after either a mixed (n D5) or a liquid (n D7) meal. Basal postprandial gallbladder contraction was severely impaired (19§2 and 26§3% of fasting volume after mixed and liquid meal, respectively). Histology and cholecystokinin sulfation patterns in duodenalbiopsiesfromtwopatientswerenormal.After6monthsofrhGHtherapy,fasting gallbladder volumes increased (from 20.8§0.9 to 25.9§1.1 mL, P <0:05) and postprandial gallbladder emptying was restored (70§6 and 70§7% of fasting volume after mixed and liquid meal, respectively), without change of gastric emptying. Cholecystokinin secretion after a mixed meal and gallbladder sensitivity to cholecystokinin were significantly enhanced during rhGH replacement compared to the basal state. Postprandial cholecystokinin release, gallbladder responsiveness to cholecystokinin, and gallbladder emptying are severely impaired in the absence of GH. Reversibility during GH suppletion suggests its involvement in regulation of gallbladder contractility
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