462 research outputs found
Comparison of different methods for diagnosis of porcine proliferative enteropathy
No full textGuedes, R.M.; Gebhart, C.J.; Winkelman, N.L.; Mackie-Nuss, R.A.; Marsteller, T.A.. (2000). Comparison of different methods for diagnosis of porcine proliferative enteropathy. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/147255
The challenging task of screening and monitoring tuberculosis infection in candidates for biological therapies
No full textComment on: Latent tuberculosis infection in patients with chronic plaque psoriasis who are candidates for biological therapy
Is quantitative real time polymerase chain reaction MCAM transcript assay really suitable for prognostic and predictive management of melanoma patients?
No full textBackground: Recent advances in next generation sequencing (NGS) technology have enabled comprehensive and accurate screening of the entire genomic region of BRCA1/2 genes and, to date, many studies report the effectiveness of these technologies. Here we show that Gene Scan (GS) labeling Quality Control (QC), performed before massive parallel pyrosequencing, coupled with Multiple Amplicon Quantification software (MAQ-S) analysis is a rapid and powerful tool in the detection of deleterious BRCA mutations carried by different patients.
Methods: GS labeling QC assay was performed according to the manufacturers' instructions and MAQ-S software was employed for analysis results.
Results: GS labeling QC was able to detect 14 different BRCA frameshift mutations in our patients. In addition, two novel BRCA mutations (c.1893_1894in5TTAAGCCCACAAAT in BRCA1 gene and c.9413_9414insT in BRCA2 gene) were identified.
Conclusion: We prove that a simple QC step may represent a valid and useful tool for a rapid detection of frameshift mutations in BRCA genes. For this reason, we recommend using this approach before massive parallel sequencing. (C) 2014 Elsevier B.V. All rights reserved
Holocene glacier history of Frank Mackie Glacier, northern British Columbia Coast Mountains
No full textFrank Mackie Glacier repeatedly advanced across the Bowser River valley in northwestern British Columbia to impound Tide Lake during the Holocene. The most recent infilling of Tide Lake was associated with a late Little Ice Age glacier advance and ended around 1930 when the lake catastrophically drained. Over the last century Frank Mackie Glacier has retreated and down wasted to reveal multiple glaciogenic sedimentary units within the proximal faces of prominent lateral moraines. The units are separated by buried in-situ tree stumps and laterally contiguous wood mats deposited on paleosols. Dendroglaciological and radiocarbon dating of these wood remains show that Frank Mackie Glacier expanded into standing forests at 3710-3300, 2700-2200, 1700-1290, 900-500, and 250-100 cal. yr BP. These advances coincide closely in time with the previously established Tide Lake glacier dam chronology and with the Holocene history of other glaciers in the Bowser River watershed. The findings emphasize the likelihood that most glaciers within northwestern British Columbia underwent substantial size and mass balance changes over the last 4000 years, and often spent hundreds of years in advanced positions before retreating.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
A variety of strategies and funding approaches are required to accelerate the transition to open access. But in all, authors are key
No full textMore than two decades of work towards liberating scholarly publishing from paywalled constraints has left many within the scholarly community exploring ways to accelerate the transition to open access. Not all institutions or author communities will agree upon which strategies or funding approaches to undertake, and nor do they need to. But whichever strategy is pursued, having university faculty lead the charge represents the most effective way forward. Rachael G. Samberg, Richard A. Schneider, Ivy Anderson and Jeff MacKie-Mason share the University of California’s range of open access policy and advocacy materials, and highlight some potential next steps that may be of use to faculty and author communities
Northern Alberta Baseball League Executive
No full textPhotograph - Northern Alberta Baseball League Executive, Athabasca, Alberta. Left to right: Jack Mackie, Jeff Edwards, B.W. Bellamy. Aug 23, 194
Setting the rules of the game: The choice of electoral systems in advanced democracies
No full textThe origins of electoral systems have received scant attention in the literature. Looking at the history of electoral rules in the advanced world in the last century, this paper shows that the existing wide variation in electoral rules across nations can be traced to the strategic decisions that the current ruling parties, anticipating the coordinating consequences of different electoral regimes, make to maximize their representation according to the following conditions. On the one hand, as long as the electoral arena does not change substantially and the current electoral regime serves the ruling parties well, the latter have no incentives to modify the electoral regime. On the other hand, as soon as the electoral arena changes (due to the entry of new voters or a change in their preferences), the ruling parties will entertain changing the electoral system, depending on two main conditions: the emergence of new parties and the coordinating capacities of the old ruling parties. Accordingly, if the new parties are strong, the old parties shift from plurality/ majority rules to proportional representation (PR) only if the latter are locked into a 'non-Duvergerian' equilibrium; i.e. if no old party enjoys a dominant position (the case of most small European states) --conversely, they do not if a Duvergerian equilibrium exists (the case of Great Britain). Similarly, whenever the new entrants are weak, a non-PR system is maintained, regardless of the structure of the old party system (the case of the USA). The paper discusses as well the role of trade and ethnic and religious heterogeneity in the adoption of PR rules.Electoral systems, political parties, institutions
Men's Curling Team
No full textPhotograph - Members of a curling team posing with a trophy, Athabasca, Alberta. Standing, left to right: Walter Mackie and N. Wilson. Seated, left to right: Capt. James W. Mills (skip) and E.G. Royd
Teaching together: School/university collaboration to improve social studies education
No full textMarsha Alibrandi (with C. Beal, A. Wilson, A. Thompson, R. Hagevik, B. Mackie, V. Owens, and N. Sinclair) is a contributing author, Students reclaim their community’s history: Conducting interdisciplinary research with technological applications .
Book description: This book provides preservice, beginning, and experienced social studies teachers with provocative ideas for and a realistic look at the challenges of developing curriculum through collaboration between elementary/secondary teachers and university professors. The book begins with an introductory essay by the editors.https://digitalcommons.fairfield.edu/education-books/1037/thumbnail.jp
A dual-target herbicidal inhibitor of lysine biosynthesis
No full textHerbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant weeds. We recently developed the first herbicidal inhibitors of lysine biosynthesis, which provided proof-of- concept for a promising novel herbicide target. In this study, we expanded upon our understanding of the mode of action of herbicidal lysine biosynthesis inhibitors. We previously postulated that these inhibitors may act as proherbicides. Here, we show this is not the case. We report an additional mode of action of these inhibitors, through their inhibition of a second lysine biosynthesis enzyme, and investigate the molecular determinants of inhibition. Furthermore, we extend our herbicidal activity analyses to include a weed species of global significance.Emily RR Mackie, Andrew S Barrow, Rebecca M Christoff, Belinda M Abbott, Anthony R Gendall, Tatiana P Soares da Cost
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