27 research outputs found
An atlas of facies microfabrics of the Bootlegger Cove Formation using the scanning electron microscope
No full textZeolites and selected other hydrothermal minerals in the Cascade Mountains of northern Oregon
No full textElectron microprobe analyses of zeolite minerals from Neogene volcanic rocks in the Breitenbush-Austen Hot Springs area, Oregon
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Effects of lighting on cognitive map development
No full textThe author has granted permission for their work to be available to the general public.Every day people use cognitive maps to successfully navigate the world around them. Research has shown that the development of these maps depends on two types of knowledge: route knowledge (which landmarks to turn at and which way to turn) and survey knowledge (bird's-eye view of the environment). This research investigates the development of these two types of knowledge as a function of whether an external referent (in this case the moon) is provided to the learner. A total of 56 participants were recruited from the SONA program. The data were analyzed using a split-plot factorial ANOVA. Consistent with the previous literature, procedural knowledge was acquired faster than survey knowledge and individual differences were correlated with the acquisition of survey knowledge. Inconsistent with the previous literature, enhancing the amount of survey information presented by removing the ceiling and adding a moon initially hindered rather than helped the measure of survey knowledge. The implications for future research are discussed.Psycholog
Experimental and molecular-dynamics simulated excess enthalpies and solubilities of neopentane in supercritical carbon dioxide
No full textThermodynamic properties of mixing for SnCl4 dissolved in supercritical CO2: a combined experimental and molecular dynamics study
No full textRegulation in practice : Standards and novice language teachers´perspectives on summative assessment in Sweden
No full textDeveloping summative assessment literacy for valid instruction is a qualification requirement for language teachers in Sweden. Yet novice teachers may be unprepared for how to implement regulations in practice. They may even experience a reality shock when facing large classes in which knowledge levels and motivation vary substantially or when adjusting to entrenched assessment cultures in schools. Previous research has measured summative assessment literacy with several theoretical criteria, but no studies have focused on the alignment between regulations and teachers' perspectives on summative assessment in Sweden. Hence, this investigation addressed 15 novice language teachers' experiences from on-campus courses, teaching practice and current workplaces. Data were collected from graduates of a Swedish university, who are working at schools in eastern central Sweden. In view of regulations and standards, the findings were then analyzed. Deliberative curriculum theory and teacher cognition constituted the conceptual framework, while constructivist grounded theory provided a methodology for analyzing the qualitative data produced. The findings show that instruction was inadequate regarding aspects such as deliberation and test construction in teacher education. The novice language teachers appreciated teaching practice. However, they argued that the quality of mentoring could vary considerably and recommended that courses devoted to assessment for bridging theory, regulations, recommendations and practice as well as stricter, structured guidelines for teaching practice should be implemented. The main conclusion is that criterion-referenced standards require early timing and ample space for instruction devoted to summative assessment in teacher education.Peer reviewe
Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
No full textThe origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. Maternal smoking during pregnancy and low birth weight is associated with increased risk of asthma, poor lung function in adults and COPD in old age. Exposure to oxidative stress and poor nutrition in utero is thought to cause damage to the lung and alter the normal course of lung development.Glutathione S-transferases (GST) are potent antioxidants. In this work, genetic polymorphisms that alter GST enzyme activity were genotyped in a family-based childhood asthma cohort (341 families, n = 1508) and analysed to investigate whether they alter the risk of developing asthma when individuals are exposed to environmental tobacco smoke. Real-time PCR based copy number variation methodology was developed to genotype the common gene deletion polymorphism of GSTT1 and GSTM1 genes, for other GST genes (GSTP1 and GSTO2) SNP haplotypes were constructed. A rare GSTO2 haplotype was negatively associated with asthma susceptibility, atopy severity, and FEV1 values. Asthmatic children with a GSTT1 gene deletion, or a common GSTP1 haplotype, developed more severe asthma compared to individuals with a GSTT1 gene or non-carriers of the GSTP1 haplotype. Total IgE levels were increased in GSTT1*0 individuals when exposed to tobacco smoke in early life, suggesting a gene-environment interaction. GSTO2 may be a shared susceptibility locus for asthma in childhood and COPD in later life.Animal models of maternal protein-restriction during pregnancy can induce hypertension, diabetes and endothelial dysfunction in offspring and in some of these models alterations to lung gene expression and lung architecture have been reported. This work established that a rat model of maternal dietary protein-restriction during pregnancy known to induce hypertension in the offspring, results in persistent alterations to the expression of genes in the lungs of adult offspring (120 days), including genes involved in glucocorticoid action (Hsd11b2), growth (Igf1 & 2 and Pcdh1) and alveolar development (Tp53). Lung microRNA expression profiles were also altered in response to exposure to protein restriction in utero. These findings suggest a role for nutritional programming in respiratory disease susceptibility in later life and a role for microRNAs in the study of the developmental origins of health and disease in general. Further work will include the investigation of epigenetic mechanisms that control nutritional programming in lungs of animals exposed to protein-restriction in utero.This work has demonstrated that GST polymorphism is a risk factor for childhood asthma and certain genotypes can offer some protection against the development of severe asthma. There was little evidence to suggest that GST polymorphism modulates the effects of smoke exposure in early life. In addition, we have demonstrated that maternal diets that are poor in nutrition could predispose her offspring to respiratory disease in later life by altering the course of normal lung development in early life or response to environmental stimuli in later life
Pathographies and Epiphanies: Communicating about Illness
No full textEpiphany is a literary device bringing forth an experience of sudden wisdom or insight and is particularly applied to literature from the romantic era. However, epiphanies are also present within contemporary autobiographical patient stories (pathographies) expressing something that is difficult and perhaps otherwise left unspoken. Kristian Gidlund’s pathography I kroppen min. Resan mot livets slut och alltings början (2013) deals with the author’s experience of having severe cancer. Gidlund was a non-religious person but at the end of his life, his blogposts included epiphanies or visionary moments regarding his afterlife. In this article the author shows how the use of epiphanies can be a subtle means of expressing thoughts and feelings when facing severe illness. Knowing how to identify and interpret epiphanies in pathographies can improve the abilities of relatives and medical staff to communicate with patients about existential matters and emotional distress. KAKA I would like to thank Rachael Reynolds and Paul Farmer for their most conscientious proofreading, and Dr. Christopher Oscarson for the accurate translation of the quotes from Kristian Gidlund’s book
